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Link to original content: https://pubmed.ncbi.nlm.nih.gov/15523479
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Review
. 2004 Nov;11(11):1037-43.
doi: 10.1038/nsmb851.

Regulated nucleosome mobility and the histone code

Michael S Cosgrove  1 , Jef D Boeke, Cynthia Wolberger
Affiliations
Review

Regulated nucleosome mobility and the histone code

Michael S Cosgrove et al. Nat Struct Mol Biol. 2004 Nov.

Abstract

Post-translational modifications of the histone tails are correlated with distinct chromatin states that regulate access to DNA. Recent proteomic analyses have revealed several new modifications in the globular nucleosome core, many of which lie at the histone-DNA interface. We interpret these modifications in light of previously published data and propose a new and testable model for how cells implement the histone code by modulating nucleosome dynamics.

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