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Link to original content: https://pubmed.ncbi.nlm.nih.gov/15145345
miRNAs on the move: miRNA biogenesis and the RNAi machinery - PubMed Skip to main page content
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Review
. 2004 Jun;16(3):223-9.
doi: 10.1016/j.ceb.2004.04.003.

miRNAs on the move: miRNA biogenesis and the RNAi machinery

Elizabeth P Murchison  1 , Gregory J Hannon
Affiliations
Review

miRNAs on the move: miRNA biogenesis and the RNAi machinery

Elizabeth P Murchison et al. Curr Opin Cell Biol. 2004 Jun.

Abstract

Recent advances have led to a more detailed understanding of RNA interference and its role in microRNA biogenesis and function. Primary microRNA transcripts are processed by the RNaseIII nuclease, Drosha, and are exported from the nucleus by Exportin-5. Dicer cleaves microRNAs into their mature forms, which can be incorporated into effector complexes that mediate gene silencing activities. The 3' two-nucleotide overhang structure, a signature of RNaseIII cleavage, has been identified as a critical specificity determinant in targeting and maintaining small RNAs in the RNA interference pathway. MicroRNA functional analyses and genetic and biochemical interrogation of components of the pathway are starting to provide a glimpse at the range of biological processes and phenomena regulated by RNA interference.

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