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Link to original content: https://pubmed.ncbi.nlm.nih.gov/1394148
An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains - PubMed Skip to main page content
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. 1992 Oct 1;52(19):5416-20.

An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains

I G Campbell  1 , P S Freemont, W Foulkes, J Trowsdale
Affiliations
  • PMID: 1394148

An ovarian tumor marker with homology to vaccinia virus contains an IgV-like region and multiple transmembrane domains

I G Campbell et al. Cancer Res. .

Abstract

The monoclonal antibody OVTL3 has a highly restricted reactivity with ovarian carcinomas and defines a surface glycoprotein, OA3, which has been used for immunotargeting. To understand why OA3 is found on ovarian tumors we isolated a complementary DNA by expression cloning. The clone encodes a 323-amino acid protein with 5 putative membrane spanning domains, reminiscent of a membrane receptor or channel, but of a new type with little or no sequence similarity with these families of proteins. Interestingly, the OA3 sequence is highly related to a vaccinia virus encoded protein (VA38) and its extracellular domain is a member of the immunoglobulin V region superfamily.

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