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Link to original content: https://pubmed.ncbi.nlm.nih.gov/12915382
Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models - PubMed Skip to main page content
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. 2003 Dec;285(6):F1060-7.
doi: 10.1152/ajprenal.00191.2002. Epub 2003 Aug 12.

Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models

Michael Zeisberg  1 , Cindy Bottiglio, Navin Kumar, Yohei Maeshima, Frank Strutz, Gerhard A Müller, Raghu Kalluri
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Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models

Michael Zeisberg et al. Am J Physiol Renal Physiol. 2003 Dec.
Free article

Abstract

Tubulointerstitial fibrosis is a hallmark feature of chronic renal injury. Specific therapies to control the progression of renal fibrosis toward end-stage renal failure are limited. Previous studies have demonstrated that expression of endogenous bone morphogenic protein-7 (BMP-7) is reduced in the kidneys of several inducible mouse models of acute and chronic renal disease and that administration of exogenous recombinant human BMP-7 (rhBMP-7) has a beneficial effect on kidney function. Here we report that treatment with rhBMP-7 leads to improved renal function, histology, and survival in mice deficient in the alpha3-chain of type IV collagen and MRL/MpJlpr/lpr lupus mice, two genetic models for chronic renal injury and fibrosis. Such therapeutic benefit is also associated with a significant decrease in the expression of profibrotic molecules, such as type I collagen and fibronectin, in renal fibroblasts. Additionally, rhBMP-7 induces expression of active matrix metalloproteinase-2, which is potentially important for removal of fibrotic matrix. Collectively, these studies provide further evidence for rhBMP-7 as an important bone-associated protein with protective function against renal pathology.

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