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Link to original content: https://pubmed.ncbi.nlm.nih.gov/12209121/
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Review
. 2002 Sep;3(9):728-39.
doi: 10.1038/nrn920.

Excitatory actions of gaba during development: the nature of the nurture

Yehezkel Ben-Ari  1
Affiliations
Review

Excitatory actions of gaba during development: the nature of the nurture

Yehezkel Ben-Ari. Nat Rev Neurosci. 2002 Sep.

Abstract

In the immature brain, GABA (gamma-aminobutyric acid) is excitatory, and GABA-releasing synapses are formed before glutamatergic contacts in a wide range of species and structures. GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions. I propose that this mechanism provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation while avoiding the potentially toxic effects of a mismatch between GABA-mediated inhibition and glutamatergic excitation. As key elements of this cascade are activity dependent, the formation of inhibition adds an element of nurture to the construction of cortical networks.

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