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Comparative Study
. 2002 Jun;70(6):1490-7.
doi: 10.1086/340787. Epub 2002 Apr 30.

Genomewide comparison of DNA sequences between humans and chimpanzees

Affiliations
Comparative Study

Genomewide comparison of DNA sequences between humans and chimpanzees

Ingo Ebersberger et al. Am J Hum Genet. 2002 Jun.

Abstract

A total of 8,859 DNA sequences encompassing approximately 1.9 million base pairs of the chimpanzee genome were sequenced and compared to corresponding human DNA sequences. Although the average sequence difference is low (1.24%), the extent of changes is markedly different among sites and types of substitutions. Whereas approximately 15% of all CpG sites have experienced changes between humans and chimpanzees, owing to a 23-fold excess of transitions and a 7-fold excess of transversions, substitutions at other sites vary in frequency, between 0.1% and 0.5%. If the nucleotide diversity in the common ancestral species of humans and chimpanzees is assumed to have been about fourfold higher than in contemporary humans, all possible comparisons between autosomes and X and Y chromosomes result in estimates of the ratio between male and female mutation rates of approximately 3. Thus, the relative time spent in the male and female germlines may be a major determinant of the overall accumulation of nucleotide substitutions. However, since the extent of divergence differs significantly among autosomes, additional unknown factors must also influence the accumulation of substitutions in the human genome.

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Figures

Figure  1
Figure 1
Histogram showing the number of DNA sequence positions compared per human chromosome
Figure  2
Figure 2
Mean DNA sequence differences between humans and chimpanzees by human chromosome. Bars indicate 95% CIs.
Figure  3
Figure 3
Frequency distribution of DNA sequence differences between chimpanzees and humans, for each human chromosome. Ti = transitions.
Figure  4
Figure 4
Genomewide average frequencies for various nucleotide differences between chimpanzees and humans (A) and among humans (B). Ti = transitions.

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References

Electronic-Database Information

    1. dbSNP Home Page, http://www.ncbi.nlm.nih.gov/SNP/
    1. Genome Software Development Page, http://www.phrap.org/
    1. Human Genome Working Draft, http://genome.ucsc.edu/
    1. Repeat Masker Server Home Page, http://repeatmasker.genome.washington.edu/
    1. UCSC Genome Browser Gateway, http://genome.ucsc.edu/cgi-bin/hgGateway?db=hg10

References

    1. Agnez-Lima LF, Napolitano RL, Fuchs RP, Mascio PD, Muotri AR, Menck CF (2001) DNA repair and sequence context affect (1)O(2)-induced mutagenesis in bacteria. Nucleic Acids Res 29:2899–2903 - PMC - PubMed
    1. Anagnostopoulos T, Green PM, Rowley G, Lewis CM, Giannelli F (1999) DNA variation in a 5-Mb region of the X chromosome and estimates of sex-specific/type-specific mutation rates. Am J Hum Genet 64:508–517 - PMC - PubMed
    1. Bailey WJ, Fitch DH, Tagle DA, Czelusniak J, Slightom JL, Goodman M (1991) Molecular evolution of the psi eta-globin gene locus: gibbon phylogeny and the hominoid slowdown. Mol Biol Evol 8:155–184 - PubMed
    1. Bernardi G (1995) The human genome: organization and evolutionary history. Annu Rev Genet 29:445–476 - PubMed
    1. Bohossian HB, Skaletsky H, Page DC (2000) Unexpectedly similar rates of nucleotide substitution found in male and female hominids. Nature 406:622–625 - PubMed

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