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Link to original content: https://pubmed.ncbi.nlm.nih.gov/11757963/
Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b - PubMed Skip to main page content
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Clinical Trial
. 2001 Nov;248(11):979-86.
doi: 10.1007/s004150170052.

Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b

S Narayanan  1 , N De Stefano, G S Francis, R Arnaoutelis, Z Caramanos, D L Collins, D Pelletier, Arnason BGW, J P Antel, D L Arnold
Affiliations
Clinical Trial

Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b

S Narayanan et al. J Neurol. 2001 Nov.

Abstract

Patients with multiple sclerosis (MS) can benefit from treatment with interferon beta-1b. However, the mechanisms of action of this drug are incompletely understood and effects of interferon beta-lb on axonal injury are not known. A measure of axonal injury can be obtained in vivo using magnetic resonance spectroscopy to quantify the resonance intensity of the neuronal marker, N-acetylaspartate (NAA). In a small pilot study, we performed combined magnetic resonance imaging and magnetic resonance spectroscopic imaging on 10 patients with relapsing-remitting MS before and 1 year after starting treatment with subcutaneous interferon beta-lb. Resonance intensities of NAA relative to creatine (Cr) were measured in a large, central brain volume. These measurements were compared with those made in a group of 6 untreated patients selected to have a similar range of scores on the Expanded Disability Status Scale and mean NAA/Cr at baseline. NAA/Cr in the treated group [2.74 (0.16), mean (SD)] showed an increase of 5.5% 12 months after the start of therapy [2.89 (0.24),p = 0.05], while NAA/Cr in the untreated group decreased, but not significantly [2.76 (0.1) at baseline, 2.65 (0.14) at 12 months,p > 0.1]. NAA/Cr had become significantly higher in the treated group at 12 months than in the untreated group (p = 0.03). Our data suggest that, in addition to losing axons, patients with chronic multiple sclerosis suffer from chronic, sublethal axonal injury that is at least partially reversible with interferon beta-lb therapy.

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