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Link to original content: https://pubmed.ncbi.nlm.nih.gov/11153912/
Y chromosome haplotypes reveal prehistorical migrations to the Himalayas - PubMed Skip to main page content
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. 2000 Dec;107(6):582-90.
doi: 10.1007/s004390000406.

Y chromosome haplotypes reveal prehistorical migrations to the Himalayas

B Su  1 , C Xiao, R Deka, M T Seielstad, D Kangwanpong, J Xiao, D Lu, P Underhill, L Cavalli-Sforza, R Chakraborty, L Jin
Affiliations

Y chromosome haplotypes reveal prehistorical migrations to the Himalayas

B Su et al. Hum Genet. 2000 Dec.

Abstract

By using 19 Y chromosome biallelic markers and 3 Y chromosome microsatellite markers, we analyzed the genetic structure of 31 indigenous Sino-Tibetan speaking populations (607 individuals) currently residing in East, Southeast, and South Asia. Our results showed that a T to C mutation at locus M122 is highly prevalent in almost all of the Sino-Tibetan populations, implying a strong genetic affinity among populations in the same language family. Furthermore, the extremely high frequency of H8, a haplotype derived from M122C, in the Sino-Tibetan speaking populations in the Himalayas including Tibet and northeast India indicated a strong bottleneck effect that occurred during a westward and then southward migration of the founding population of Tibeto-Burmans. We, therefore, postulate that the ancient people, who lived in the upper-middle Yellow River basin about 10,000 years ago and developed one of the earliest Neolithic cultures in East Asia, were the ancestors of modern Sino-Tibetan populations.

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