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Link to original content: https://pubmed.ncbi.nlm.nih.gov/11065142/
Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease - PubMed Skip to main page content
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. 2000 Oct 20;293(1):75-7.
doi: 10.1016/s0304-3940(00)01487-7.

Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease

G W Rebeck  1
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Confirmation of the genetic association of interleukin-1A with early onset sporadic Alzheimer's disease

G W Rebeck. Neurosci Lett. .

Abstract

An association between altered risk of Alzheimer's disease (AD) and the interleukin-1A (IL-1A) gene was recently reported in two independent studies. Here, the IL-1A polymorphism was analyzed in a third population of 247 AD patients and 187 control individuals. In support of the published findings, the IL-1A 2/2 genotype was associated with an increased risk of early onset AD (odds ratio of 3.1, P = 0.02). Clinically, the IL-1A 2/2 genotype was associated with an earlier age of onset, but not with a change in the rate of progression of AD.

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