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Link to original content: https://pubmed.ncbi.nlm.nih.gov/10833312/
Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo - PubMed Skip to main page content
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. 2000 Jun;163(2):388-91.
doi: 10.1006/exnr.2000.7393.

Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo

J G Sheng  1 , S G Zhu, R A Jones, W S Griffin, R E Mrak
Affiliations

Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo

J G Sheng et al. Exp Neurol. 2000 Jun.

Abstract

Slow-release, IL-1-impregnated pellets implanted in rat cerebral cortex to simulate chronic overexpression of IL-1 significantly increased relative tissue levels of tau mRNA and of tau immunoreactivity in neuronal cell bodies and in swollen dystrophic neurites that also overexpressed phosphorylated and nonphosphorylated neurofilament epitopes. In addition, rats with IL-1-impregnated pellets, but not control rats or those with sham pellets, showed focal immunoreactivity for hyperphosphorylated tau epitopes present in paired helical filaments. Our results are consistent with an important driving role for IL-1 in the pathogenesis of Alzheimer-type neuronal and neuritic changes.

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Figures

FIG. 1
FIG. 1
Photomicrographs of hippocampus showing immunoreactivity for phosphorylated neurofilament (SMI-31; A–C), for tau (D–F), and for paired helical filament (PHF; G–I) in rats carrying IL-1β pellets (A, D, G), sham (inert) pellets (B, E, H), and normal (unoperated) (C, F, I) rats. Phosphorylated neurofilament, Tau, and PHF protein immunoreactivity is increased in perikarya and processes of neurons in hippocampus of IL-1β pellet-implanted rats. Bars, 15 μm.
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