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Link to original content: https://pubmed.ncbi.nlm.nih.gov/10688427
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Review
. 1999 Dec;54(12):1233-51.
doi: 10.1034/j.1398-9995.1999.00099.x.

Biologic functions of the IFN-gamma receptors

G Tau  1 , P Rothman
Affiliations
Review

Biologic functions of the IFN-gamma receptors

G Tau et al. Allergy. 1999 Dec.

Abstract

Interferon-gamma (IFN-gamma) is a cytokine that plays an important role in inducing and modulating an array of immune responses. Cellular responses to IFN-gamma are mediated by its heterodimeric cell-surface receptor (IFN-gammaR), which activates downstream signal transduction cascades, ultimately leading to the regulation of gene expression. In order to study the role of IFN-gamma in a number of immune responses and pathways, researchers have generated mice with altered patterns of IFN-gammaR gene expression. These studies, together with analyses of naturally occurring mutations of the IFN-gammaR in man, have been instrumental in elucidating the diverse functions of IFN-gamma, and are the subject of this review.

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Figures

Figure 1
Figure 1
IFN‐γ signaling cascade. A) IFN‐γR is composed of α and β chains. JAK1 is constitutively associated with IFN‐γR1 while JAK2 is constitutively associated with IFN‐γR2. B) IFN‐γ binding to its receptor leads to aggregation of receptor components. Subsequently, JAKs are activated through auto‐ and transphosphorylation events. Activated JAKs then phosphorylate tyrosine residue near C‐terminus of IFN‐γR1. C) STAT1 molecules dock at phosphorylated receptor, and are then phosphorylated by activated JAKs. D) Phosphorylated STAT1 proteins homodimerize via reciprocal SH2‐phosphotyrosine interactions, and translocate to nucleus, where they regulate gene transcription.
Figure 2
Figure 2
Effects of IFN‐γR on T helper subset differentiation.
See this image and copyright information in PMC

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