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Link to original content: https://pubmed.ncbi.nlm.nih.gov/10512743
IL1HY1: A novel interleukin-1 receptor antagonist gene - PubMed Skip to main page content
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. 1999 Oct 5;263(3):702-6.
doi: 10.1006/bbrc.1999.1440.

IL1HY1: A novel interleukin-1 receptor antagonist gene

J J Mulero  1 , A M Pace, S T Nelken, D B Loeb, T R Correa, R Drmanac, J E Ford
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IL1HY1: A novel interleukin-1 receptor antagonist gene

J J Mulero et al. Biochem Biophys Res Commun. .

Abstract

Interleukin-1 is a potent mediator of inflammation, involved in regulating a wide variety of physiological and cellular events. We have identified and characterized a novel member of the human interleukin-1 gene family (IL1HY1). The encoded protein demonstrates significant amino acid homology to the receptor antagonist (IL-1ra) at 52%. The gene was mapped to the long arm of chromosome 2, in close proximity to the IL-1 locus. IL1HY1 message is tightly regulated being most predominantly expressed in the skin, but also detected in the spleen, brain leukocyte, and macrophage cell types. Furthermore, the message can be induced in THP-1 cells by phorbol ester (PMA) and lipopolysaccharide (LPS) treatment.

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