iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: https://pubmed.ncbi.nlm.nih.gov/10481909/
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1999 Aug 20;98(4):437-51.
doi: 10.1016/s0092-8674(00)81973-x.

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

R M Chemelli  1 , J T Willie, C M Sinton, J K Elmquist, T Scammell, C Lee, J A Richardson, S C Williams, Y Xiong, Y Kisanuki, T E Fitch, M Nakazato, R E Hammer, C B Saper, M Yanagisawa
Affiliations
Free article
Comparative Study

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

R M Chemelli et al. Cell. .
Free article

Abstract

Neurons containing the neuropeptide orexin (hypocretin) are located exclusively in the lateral hypothalamus and send axons to numerous regions throughout the central nervous system, including the major nuclei implicated in sleep regulation. Here, we report that, by behavioral and electroencephalographic criteria, orexin knockout mice exhibit a phenotype strikingly similar to human narcolepsy patients, as well as canarc-1 mutant dogs, the only known monogenic model of narcolepsy. Moreover, modafinil, an anti-narcoleptic drug with ill-defined mechanisms of action, activates orexin-containing neurons. We propose that orexin regulates sleep/wakefulness states, and that orexin knockout mice are a model of human narcolepsy, a disorder characterized primarily by rapid eye movement (REM) sleep dysregulation.

PubMed Disclaimer

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources