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Link to original content: https://omim.org/entry/605240
Entry - *605240 - CHEMOKINE, CC MOTIF, LIGAND 28; CCL28 - OMIM
 
* 605240

CHEMOKINE, CC MOTIF, LIGAND 28; CCL28


HGNC Approved Gene Symbol: CCL28

Cytogenetic location: 5p12   Genomic coordinates (GRCh38) : 5:43,356,975-43,412,391 (from NCBI)


TEXT

For background information on chemokines, see CCL27 (SCYA27; 604833).


Cloning and Expression

By searching an EST database using a consensus chemokine sequence, Wang et al. (2000) identified ESTs encoding CCL28. Sequence analysis predicted that the 127-amino acid CCL28 protein contains a 22-amino acid N-terminal signal peptide. Northern blot analysis detected 0.8-, 1.3-, and 6.0-kb CCL28 transcripts predominantly in prostate, colon, spleen, and to a lesser degree in peripheral blood leukocytes. Immunohistochemical analysis detected CCL28 expression in epithelial cells of normal colon. Quantitative PCR analysis demonstrated high expression of CCL28 in cDNA libraries derived from organs where epithelial cells are localized, including samples from ulcerative colitis (see 266600) tissues.


Gene Function

Functional analysis by Wang et al. (2000) showed that CCL28 is chemotactic for resting CD4 (186940) and CD8 (see 186910) T cells and fails to mobilize calcium in cells expressing known CC chemokine receptors (CCRs, e.g., CCR9; 604738) or CXC chemokine receptors (CXCRs, e.g., BLR1; 601613). Wang et al. (2000) determined that CCL28 does mobilize calcium in cells expressing CCR10 (GPR2; 600240), which it shares with the skin chemokine, CCL27.

Wilson and Butcher (2004) found that Ccl28 was upregulated in mouse mammary gland during lactation and that IgA antibody-secreting cells (ASCs) in the gland expressed Ccr10 and migrated to Ccl28. Antibody to Ccl28 blocked IgA ASC accumulation in mammary gland, inhibiting secretion of IgA into milk and the appearance of antibody in the gastrointestinal tract of nursing neonatal mice. Wilson and Butcher (2004) proposed that CCL28 is a key regulator of IgA ASC accumulation in the mammary gland and thereby controls passive transfer of IgA antibodies from mother to infant.

Facciabene et al. (2011) showed that tumor hypoxia promotes the recruitment of regulatory T (Treg) cells through induction of expression of the chemokine CCL28, which in turn promotes tumor tolerance and angiogenesis. Facciabene et al. (2011) concluded that peripheral immune tolerance and angiogenesis programs are closely connected and cooperate to sustain tumor growth.


Mapping

Wang et al. (2000) mapped the mouse Ccl28 gene to the distal region of chromosome 13, which shows homology of synteny to human 5q. The authors noted that this localization would place CCL28 outside the CCL cluster in chromosome 17. Scott (2000) mapped the CCL28 gene to chromosome 5 based on sequence similarity between the CCL28 sequence (GenBank AF220210) and the chromosome 5 clones CTD-2202K16 (GenBank AC025457), CTD-2282F8 (GenBank AC010465), and CTD-2201J22 (GenBank AC022132).


REFERENCES

  1. Facciabene, A., Peng, X., Hagemann, I. S., Balint, K., Barchetti, A., Wang, L.-P., Gimotty, P. A., Gilks, C. B., Lal, P., Zhang, L., Coukos, G. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 475: 226-230, 2011. [PubMed: 21753853, related citations] [Full Text]

  2. Scott, A. F. Personal Communication. Baltimore, Md. 8/29/2000.

  3. Wang, W., Soto, H., Oldham, E. R., Buchanan, M. E., Homey, B., Catron, D., Jenkins, N., Copeland, N. G., Gilbert, D. J., Nguyen, N., Abrams, J., Kershenovich, D., Smith, K., McClanahan, T., Vicari, A. P., Zlotnik, A. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J. Biol. Chem. 275: 22313-22323, 2000. [PubMed: 10781587, related citations] [Full Text]

  4. Wilson, E., Butcher, E. C. CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate. J. Exp. Med. 200: 805-809, 2004. Note: Erratum: J. Exp. Med. 200: following 1089, 2004. [PubMed: 15381732, images, related citations] [Full Text]


Ada Hamosh - updated : 8/24/2011
Paul J. Converse - updated : 3/13/2006
Creation Date:
Paul J. Converse : 8/29/2000
terry : 04/04/2013
alopez : 8/25/2011
terry : 8/24/2011
carol : 10/29/2008
mgross : 3/13/2006
mgross : 9/26/2002
mgross : 8/29/2000

* 605240

CHEMOKINE, CC MOTIF, LIGAND 28; CCL28


HGNC Approved Gene Symbol: CCL28

Cytogenetic location: 5p12   Genomic coordinates (GRCh38) : 5:43,356,975-43,412,391 (from NCBI)


TEXT

For background information on chemokines, see CCL27 (SCYA27; 604833).


Cloning and Expression

By searching an EST database using a consensus chemokine sequence, Wang et al. (2000) identified ESTs encoding CCL28. Sequence analysis predicted that the 127-amino acid CCL28 protein contains a 22-amino acid N-terminal signal peptide. Northern blot analysis detected 0.8-, 1.3-, and 6.0-kb CCL28 transcripts predominantly in prostate, colon, spleen, and to a lesser degree in peripheral blood leukocytes. Immunohistochemical analysis detected CCL28 expression in epithelial cells of normal colon. Quantitative PCR analysis demonstrated high expression of CCL28 in cDNA libraries derived from organs where epithelial cells are localized, including samples from ulcerative colitis (see 266600) tissues.


Gene Function

Functional analysis by Wang et al. (2000) showed that CCL28 is chemotactic for resting CD4 (186940) and CD8 (see 186910) T cells and fails to mobilize calcium in cells expressing known CC chemokine receptors (CCRs, e.g., CCR9; 604738) or CXC chemokine receptors (CXCRs, e.g., BLR1; 601613). Wang et al. (2000) determined that CCL28 does mobilize calcium in cells expressing CCR10 (GPR2; 600240), which it shares with the skin chemokine, CCL27.

Wilson and Butcher (2004) found that Ccl28 was upregulated in mouse mammary gland during lactation and that IgA antibody-secreting cells (ASCs) in the gland expressed Ccr10 and migrated to Ccl28. Antibody to Ccl28 blocked IgA ASC accumulation in mammary gland, inhibiting secretion of IgA into milk and the appearance of antibody in the gastrointestinal tract of nursing neonatal mice. Wilson and Butcher (2004) proposed that CCL28 is a key regulator of IgA ASC accumulation in the mammary gland and thereby controls passive transfer of IgA antibodies from mother to infant.

Facciabene et al. (2011) showed that tumor hypoxia promotes the recruitment of regulatory T (Treg) cells through induction of expression of the chemokine CCL28, which in turn promotes tumor tolerance and angiogenesis. Facciabene et al. (2011) concluded that peripheral immune tolerance and angiogenesis programs are closely connected and cooperate to sustain tumor growth.


Mapping

Wang et al. (2000) mapped the mouse Ccl28 gene to the distal region of chromosome 13, which shows homology of synteny to human 5q. The authors noted that this localization would place CCL28 outside the CCL cluster in chromosome 17. Scott (2000) mapped the CCL28 gene to chromosome 5 based on sequence similarity between the CCL28 sequence (GenBank AF220210) and the chromosome 5 clones CTD-2202K16 (GenBank AC025457), CTD-2282F8 (GenBank AC010465), and CTD-2201J22 (GenBank AC022132).


REFERENCES

  1. Facciabene, A., Peng, X., Hagemann, I. S., Balint, K., Barchetti, A., Wang, L.-P., Gimotty, P. A., Gilks, C. B., Lal, P., Zhang, L., Coukos, G. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 475: 226-230, 2011. [PubMed: 21753853] [Full Text: https://doi.org/10.1038/nature10169]

  2. Scott, A. F. Personal Communication. Baltimore, Md. 8/29/2000.

  3. Wang, W., Soto, H., Oldham, E. R., Buchanan, M. E., Homey, B., Catron, D., Jenkins, N., Copeland, N. G., Gilbert, D. J., Nguyen, N., Abrams, J., Kershenovich, D., Smith, K., McClanahan, T., Vicari, A. P., Zlotnik, A. Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J. Biol. Chem. 275: 22313-22323, 2000. [PubMed: 10781587] [Full Text: https://doi.org/10.1074/jbc.M001461200]

  4. Wilson, E., Butcher, E. C. CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate. J. Exp. Med. 200: 805-809, 2004. Note: Erratum: J. Exp. Med. 200: following 1089, 2004. [PubMed: 15381732] [Full Text: https://doi.org/10.1084/jem.20041069]


Contributors:
Ada Hamosh - updated : 8/24/2011
Paul J. Converse - updated : 3/13/2006

Creation Date:
Paul J. Converse : 8/29/2000

Edit History:
terry : 04/04/2013
alopez : 8/25/2011
terry : 8/24/2011
carol : 10/29/2008
mgross : 3/13/2006
mgross : 9/26/2002
mgross : 8/29/2000