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Link to original content: https://link.springer.com/doi/10.1007/978-1-60761-786-0_1
Hypoxic Tumors and Their Effect on Immune Cells and Cancer Therapy | SpringerLink
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Hypoxic Tumors and Their Effect on Immune Cells and Cancer Therapy

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Immunotherapy of Cancer

Part of the book series: Methods in Molecular Biology ((MIMB,volume 651))

Abstract

The abnormal decrease or the lack of oxygen supply to cells and tissues is called hypoxia. This condition is commonly seen in various diseases such as rheumatoid arthritis and atherosclerosis, also in solid cancers. Pre-clinical and clinical studies have shown that hypoxic cancers are extremely aggressive, resistant to standard therapies (chemotherapy and radiotherapy), and thus very difficult to eradicate. Hypoxia affects both the tumor and the immune cells via various pathways. This review summarizes the most common effects of hypoxia on immune cells that play a key role in the anti-tumor response, the limitation of current therapies, and the potential solutions that were developed for hypoxic malignancies.

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  1. Baylor College of Medicine, Methodist Hospital and Texas Children’s Hospital, Houston, TX, USA

    Danli Wu & Anna May Swanson

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  1. Patricia Yotnda
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    Patricia Yotnda

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Yotnda, P., Wu, D., Swanson, A.M. (2010). Hypoxic Tumors and Their Effect on Immune Cells and Cancer Therapy. In: Yotnda, P. (eds) Immunotherapy of Cancer. Methods in Molecular Biology, vol 651. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-786-0_1

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