Currently, there is sparse literature on epidemiology of sundown syndrome. Data available on prevalence rates for sundown syndrome is variable. It depends on patient population and setting. According to the data from Alzheimer's Association in 2006, 2.4% to 25% patients diagnosed with Alzheimer's disease (AD) had sundown syndrome.²¹ Currently, there is no data on prevalence in gender, race and types of dementing disorders. Although the prevalence of sundowning among patients with severe dementia is particularly high, this syndrome appears to affect virtually all patients with some degree of cognitive impairment.^1,22 Sundowning is considered to be the second most common type of disruptive behavior in institutionalized patients with dementia after wandering.²³ It appears to be endemic among institutionalized adults with dementia. Evans in her study at a nursing home facility found that 12.4% of elderly patients from general nursing home population demonstrated significant changes in cognitive status in the late afternoon.¹³ Based on various data, the overall rates of sundowning among patients with AD or other types of dementia ranges from 2.4% to 66%.^10,20-25 Gallagher-Thompson and associates, reported that the prevalence of sundowning as high as 66% among patients living at home.²⁶ Based on available data, it is impossible to do a valid comparative analysis of prevalence of sundowning syndrome in two different patient populations: institutionalized and non-institutionalized. The severity of cognitive impairment may be one of the important predisposing factors in the development of sundown syndrome.²² Volicer at al.⁴ reported that sundowning was also linked to the seasons with increased incidence in the fall or winter months due to a decrease in duration and amount of sunlight.

The exact cause of sundown syndrome is unknown. Several theories have been proposed to understand the clinical phenomenon of sundowning. Studies that have attempted to explain etiology of sundown syndrome can be divided into three major groups: physiological, psychological, and environmental.²²

One of the earliest studies on environmental factors and psy-chophysiological variables in development of "nocturnal delirium" was done by Cameron1 in 1941. Ancoli-Israel et al.²⁷ indicated that patients with AD already have inadequate exposure to amounts of light during the day. This finding formulates the rationale for light therapy in demented patients. Morley²⁸ described a person with visual impairment due to macular degeneration, who repeatedly developed classic sundowning syndrome with changes in perception as day shifted into twilight. Among many factors, Smith²⁹ indicated that low lighting and increased shadows may aggravate late-day confusion and sundowning. Duckett²² has suggested significant differences in amount of light in various parts of the hospital that may not be readily apparent to the healthy eye. This suggestion was discussed as the basis for modification of ambient light by "matching light readings attained from the day and evening hours."²²

Majority of recent studies have focused on the important potential role of disordered circadian rhythm as an etiological factor of sundown syndrome in patients with dementia. According to these studies, sundowning as a nonspecific symptom of different types of dementia may be a manifestation of specific path physiologic abnormalities that interfere with normal circadian rhythm and behavioral regulation.^4,20,30-34 In one study which investigated sundowning phenomenon in terms of disturbance in circadian rhythm or changes in sleep-wake cycles, Feinberg et al.³⁴ reported that the elderly persons demonstrated an earlier onset of dream periods, as well as more frequent and abrupt awakenings episodes. They looked at nocturnal delirium as a transitional state from dreaming to wakefulness, and abrupt intrusion of dreams into a waking state. Evans¹³ by reviewing the medical charts of a group of institutionalized elderly persons who were suffering from sundowning, has shown a significant relationship between sundowning and disturbances in circadian rhythms. Although the exact time, precise relationship between sundowning symptoms and late afternoon, or sunset hours are not determined yet, there is numerous evidence in the medical literature of the existence of a circadian rhythm for disrupted behaviors in many patients with AD that peaks in intensity late in the day.^8,13,35 Satlin et al.²⁰ reported that patients with severe AD have a greater total daily motor activity during niht time, as well as less strictly circadian rhythm for motor activity, com-pared to healthy elderly persons. Another companion study by the same group of researchers has revealed the opposite findings that subjects with severe dementia had less diurnal motor activity and a higher intensity of nocturnal activity, compared to control group. The study conducted by Evans¹³ was consistent with above findings about the relationships between circadian rhythm disturbances and severity of cognitive and behavioral deterioration in demented subjects.

The central components of the physiological basis of the biological circadian rhythm include the suprachiasmatic nucleus (SCN) and melatonin.³⁶ The SCN located in hypothalamus plays an important role in circadian rhythm regulation during awake state by producing an alerting signal; during sleep time SCN produces a sleep-inducing signal.³⁷ In humans, the circadian rhythm is responsible for sleep-wake cycling.⁴ The SCN acts as the major circadian pacemaker of the human body and influences several physiological functions including the core body temperature, heart rate, and hormone secretion. ³⁸ Disruption of the circadian rhythms due to deterioration of the SCN observed in patients with AD may contribute to the development of sundowning syndrome.^10,36 The possible cause of the SCN deterioration is due to senile plaque formation that increases with age.¹⁰ These pathological changes may theoretically explain disturbed sleep, agitation, confusion, and other symptoms of sundowning. It is suggested that the volume of SCN, as well as its cell number decreases in persons between the ages of 80 and 100 years. Patients with dementia of the Alzheimer's type have more prominent abnormalities in SCN.³⁶ Some researchers have found evidence of deterioration in the SCN at autopsy in patients with AD.^36,39 Huitron-Resendiz et al.⁴⁰ demonstrated evidence for a relationship between AD pathology and circadian rhythm disturbance that has been revealed by studies in transgenic AD mouse models. According to this investigation, aged platelet-derived beta-amyloid precursor protein (PDAPP) transgenic mice exhibited marked sleep deficits in REM and non-REM sleep, as well as deficits in circadian distribution of sleep-wake states.⁴⁰ Data from other studies suggests a possible casual similarity to human sundowning behavior as they reported that the APP23 transgenic mouse model of AD has shown increased motor activation during the second half of the active phase, specifically at ages 6 months and 12 months.^41,42 Another important component of circadian rhythm regulation is melatonin, a hormone produced by the pineal gland in darkness, and during sleep.⁴⁰ Liu et al.⁴³ demonstrated that melatonin level has found to be decreased in the postmortem cerebrospinal fluid levels of patients with AD. This decrease causes deregulation in circadian rhythm and lessens the neuroprotective effect on the SCN.⁴⁴ Natural production of melatonin appears to decrease with aging, which could alter arteriolar wall in elderly persons.⁴⁵ This explains the rationale for use of melatonin in AD.^40,46-48

According to epidemiological studies, disturbances in duration and quality of sleep increase with aging, and occur in approximately 38% of persons over 65-year-old.^49,50 36% experience difficulties in sleep initiation and 29% suffer from difficulties in sleep maintenance.⁵⁰ Hess 3 reported that almost half the patients with dementia experience clinically relevant sleep-wake disturbances. Jelicic et al.⁵¹ demonstrated that subjective sleep disturbances in later life may potentially predict cognitive decline, and negatively correlate with cognitive performance. Bliwise et al.³⁰ suggested that disturbances in night sleep correlate with severity of dementia. Based on literature, 34-43% of the patients with AD suffer from various sleep disturbances.^52,53 Sleep disturbances in AD, including disrupted chronobiology, sleep disordered breathing, and increased daytime napping, are suggested to be multifactorial.⁵⁴ Although the contribution of sleep disturbances in development of late afternoon or early evening behavioral disruptions in dementia has not been established, there are some evidence about possible relationship between them. According to Bliwise and associates,^54,55 increased incidence of sleep disorders in patients with AD may explain nighttime worsening of behavior. REM-sleep disturbances, along with sleep apnea and dysregulation of SCN, are among suggested hypotheses for a possible physiological explanation of sundowning syndrome.⁵⁶ According to this hypothesis, neuronal degeneration of cholinergic nucleus basalis of Meynert (NBM) neurons which modulate the activity of SCN and the induction of non-REM sleep, causes rest-activity cycle disturbances, and promotes sundowning in patients with AD.⁵⁴ It was reported that patients with dementia have various sleep architecture changes, including an increase in stage I and II sleep, a decrease in stage III and stage IV, decreased consolidation of non-REM sleep, lower sleep efficiency, an increased sleep fragmentation and episodes of awakenings, nocturnal wandering, an increase in daytime napping, as well as higher incidence of disruptive nocturnal behavior.^47-49 Martin et al.⁵⁷ reported that 42% of demented nursing home residents suffer from syndrome of sleep apnea. Rest-less leg syndrome (RLS) and periodic leg movement syndrome (PLMS) are underdiagnosed in elderly demented patients due to inability to describe their symptoms. Patients taking selective serotonin reuptake inhibitor, antipsychotic, and other dopamine depleting medications may potentially develop PLMS as a side effect.⁵⁸ Although there is increased incidence of various sleep disturbances in demented patients, the relationship between sundowing and sleep abnormalities has not been studied to date. Sleep studies should be done to diagnose RLS and PLMS in demented patients with increased daytime sleepiness, and hyperkinetic parasomnias (REM sleep behavior disorder) which may potentially induce, imitate, or complicate sundown syndrome.² Vitiello et al.⁵⁵ reported that initial stages of AD are characterized by decreased time in stage 3 and 4 non-REM sleep, as well as increased nighttime wakefulness. There is a tendency towards progressive REM sleep loss in more advanced stages of the disease.⁵⁵ Sleep disruption is not pathognomonic to AD, and several studies demonstrated significant sleep disturbances in other types of dementia. In Parkinson's disease and Lewy body dementia sleep disruptions may be even more prominent than in AD.^30,55,57,58 Harper et al.³² reported that patients with frontotemporal dementia and dementia related to subcortical infarcts, experience less disruption of nighttime sleep than in AD. Hess³ has found that in Parkinson's disease, vascular dementia, Korsakoff syndrome, and depression the deterioration of sleep architecture may be prominent, whereas patients with AD experienced marked hypersomnolence or insomnia mostly in advanced stages of the disease. Other theories suggest that sleep fragmentation is important etiologic factor in sundowning. Bliwise et al.⁵⁶ found that awakenings after sunset time, spontaneous or related to nursing care, induced agitated behavior more frequently in demented nursing home residents.

Cohen-Mansfield et al.⁵⁸ studied the temporal pattern of agitation and fatigue in nursing home residents with dementia. According to this study, only a minority of agitated nursing home residents, especially those with higher baseline level of agitation, showed increased intensity of agitation after 4:00 PM. This finding was not in agreement with widely accepted notion about temporal relation between sunset period and peak in behavioral disruptions including agitation. Patient's confusion, as a manifestation of sundowning, may be a result of the chronic fatigue and disturbed sleep-wake cycle.⁶⁰ Afternoon fatigue, caregiver fatigue, and overstimulation in the environment, as well as shifts change around 3:00 PM when there is more noise and general chaos, all are contributing factors to sundowning.^61,62 High level of activity in the morning hours and during the day may cause afternoon or evening fatigue, and then lead to increased irritability and agitation in demented patients.⁶³

Rindlisbacher and Hopkins⁵ measured agitation in demented Alzheimer's patients in terms of motor activity. Analyses showed that some subjects in this study demonstrated increased afternoon activity, but these subjects did not correspond to nursing-assigned groups of 'sundowners' and 'non-sundowners'. Movement correlates of "sundowning" were seen in patients with AD presumably in the mid-stages of the dementia, and less so in patients with more advanced stages of the disease.⁵ Cohen-Mansfield et al.¹¹ assumed that screaming at night may occur in dementia patients as a response to social isolation. Another possible environmental contributor to sundowning is the lower staff-patient ratio in institutions, or lessened availability of home caregivers at that time of day. It decreases the intensity of structured stimulation for patients, increases boredom, and consequently leads to agitation, restlessness, and other behavioral disruptions associated behavior disorder. On the other hand, with high prevalence of sundowning (66% among patients living at home), sundowning behavior in demented patient lead to inadequate, fragmented sleep in caregiver, and increases caregiver stress, which may increase the likelihood of sundowning.^26,64,65 Not surprisingly, caregiver stress and burnout may increase the likelihood of institutionalization for the patient.^64,65 Staff/patient conflicts may arise from lack of communication, splitting staff as a result of the demented patient's specific pathology, or frustration and distress due to decreased physical independence.²²

According to two different studies conducted by Volicer⁴ and Satlin,²⁰ AD causes disturbances of circadian rhythms and normal daily cycle of changes in body temperature, and sundown syndrome appears to be related to phase delay of body temperature, the changes that normally occur in the evening. Also, the patients with AD had less intense motor activity during the day, a higher percentage of activities during the night, lower interdaily stability of motor activity, and a later activity acrophase (time of peak) than did the healthy subjects. Besides that, subjects in this study had a higher mesor (fitted mean) temperature, higher amplitude of the fitted cosine temperature curve, as well as later temperature acrophase than did the healthy individuals. It was established that the severity of sundowning was associated with later acrophase of temperature, less correlation of circadian temperature rhythm within a 24-hour cycle, and also lower amplitude of temperature curve.⁴ This study revealed also that "sundowning" patients have prone to more chaotic temperature rhythm that had minimal relationship to the motor activity recorded. Satlin et al.²⁰ found that both, motor activity and body temperature rhythms had later acrophases (time of peak values). Lee et al.⁶⁶ examined the difference in 24-hour rhythms of sleep-wake cycle and temperature between AD patients and elderly subjects as a control group. They demonstrated that the mean acrophase (time of peak values) and amplitudes of the two rhythms in the AD group were not significantly different from those in the control group. However, the mean phase difference between the two rhythms was significantly lower in the group of patients with AD than in the control group.⁶⁶

Numerous geriatricians share opinion that sundowning may be a side effect or the "wearing-off" effect of various medications. Several drugs may induce restlessness, akathisia, or more serious movement disorders by causing extrapyramidal symptoms (antidepressants, antipsychotics). Dyskinesias may be secondary to on-off phenomena of anti-Parkinsonian drugs. Some medications may worsen cognition (e.g., through anticholinergic side effects).⁶³ It is well-known fact that virtually, any pharmacological agent, and combination of different medications may induce cognitive, affective, and behavioral changes in patients with dementia. Moreover, medications that are used to treat above mentioned changes may worsen previouslyexisting pathology. Hypnotics, benzodiazepines, and low-potency antipsychotics are among conventional therapy that used to manage evening agitation and behavioral disruptions associated with sundowning. Side-effects of such medications, including akathisia, tardive dyskinesia, muscle rigidity, anticholinergic toxicity (tachycardia, constipation, and confusion), orthostatic hypotension, and others may further contribute to development of sundowning in demented patients. Widely used benzodiazepines and other hypnotics to control nocturnal agitation, are considered to be a poor drugs of choice for elderly patients who often have several comorbidities. They tend to create drug tolerance, dependence, withdrawal, and even significantly increase the risk of respiratory and cen-tral nervous system depression. These drugs may cause paradoxical agitation, increase disinhibition and confusion in elderly patients with preexisting agitation who have sundowning syndrome.²²

A vast variety of medical factors can contribute to temporally associated agitation. For example, some diseases in which pain is intense may initiate or worsen cognitive, affective, or behavioral disturbances in the late afternoon. Bachman et al.⁶³ reported that agitation may be a manifestation of the response to temporal variation in pain. Mood variability in some demented patients may have predictable pattern, and in major depression worsening of mood in the evening hours (which may characterize atypical pattern of major depression), might possibly explain some cases of sundowning.⁶³ It can be hypothesized that agitation and changes in activity in demented patients with depression may be manifested as sundowning; taking into consideration difficulties in eliciting other symptoms of depression in cognitively impaired individuals.⁶³ Some researchers theorize that hunger, changes in blood glucose levels after eating in patients with diabetes, or a drop in blood pressure after a meal (which temporarily deprives brain from oxygen), may bring on agitation and confusion in susceptible individuals.⁶⁷

Diagnosis of sundown syndrome is purely clinical, and characterized by wide variety of cognitive, affective, and behavioral abnormalities which all have temporal pattern with symptom emergence or worsening in late afternoon, at evening, or at night. There has not been found any data on specific laboratory findings, imaging studies, or electrophysiologic studies in sundown syndrome in researched medical literature. It is not intent of this literature review to provide a comprehensive search specifically on diagnosis of sundowning syndrome.

A major difference between sundowning and delirium will be that delirium tends to be relatively acute in onset, relatively brief (a matter of hours or days), and fluctuating in the course of the day. Although fluctuating, delirium will not share the pattern of fluctuation characterized for sundowning, when prominent onset and exacerbation of cognitive and behavioral disruption brought on by late afternoon, early evening, or night hours. Therefore, the cardinal differentiation between delirium and sundowning is supposed to be made in terms of temporal characteristics, and primarily, on the basis of the onset and termination. It is not known to date, whether the pathophysiological mechanisms involved with the demented patient in the onset of sundowning are the identical or at least similar to delirium.^68,69 In majority of cases, patients already have some degree of medical or cognitive compromise prior to the development of sundowning. Moreover, in demented patients there is always a possibility of delirium due to various medical reasons, and there is a great challenge for clinician to differentiate delirium due to medical condition from sundowning in cognitively compromised patients. It was suggested that delirium may be a pre-condition for nocturnal delirium. In respect to differentiation between delirium, and sundowning, Duckett²² stated that dementia may in fact be a necessary but not a sufficient condition: not all demented patients sundown, but virtually all sundowning patients are demented, as well as delirious at the time of their sundowning episode.

Both non-pharmacologic and pharmacologic approaches have been considered in the treatment of patients with sundowning. According to the reviewed literature, among medical factors which may contribute to sundowning in the elderly individuals with dementia are: chronic pain syndrome due to arthritis and malignancy, organ systemic disorders (including congestive heart failure, ischemic heart disease, asthma, chronic obstructive pulmonary disease, gastroesophageal reflux, incontinence, benign prostatic hypertrophy), psychiatric conditions (including depression, anxiety, psychosis), and effects of various medications.^19,63,70 In demented patients, physical discomfort and illness may also be expressed as behavioral abnormalities. Individuals with AD are not able to react to pain or other physical discomfort in standard ways, as well as to relate to their body properly. That is why elderly demented patients often use aggression and other behaviors, such as yelling, screaming and refusing to eat to express pain or other physical symptoms. It was suggested to use "S-M-A-R-T"⁷¹ or "P.I.E.C.E.S."⁷² approaches in management of dementia-related behavioral problems. The former includes Safety, medical work-up, assessment of competency, rest/review of causes of behavioral abnormalities, and trial of medications. The latter includes considering physical problems, Intellectual/cognitive changes, emotional problems, capabilities, environment, social/cultural issues. Considering sundowning symptoms being a part of behavioral and psychological symptoms of dementia, it is reasonable to use the same "S-M-A-R-T" or "P.I.E.C.E.S" approaches in complex treatment of behavioral manifestations of sundown syndrome. Therefore, before considering any specific treatment for sundown syndrome in elderly demented patients, it is reasonable to gather a careful history, perform thorough physical examination, and laboratory investigations in order to evaluate a patient for temporal patterns of agitation and other manifestations of sundowning syndrome, and its possible connection to various medical conditions. According to data from current medical literature, the following interventions have been tried and found to be somewhat effective for the treatment of sundowning in demented patients: bright light therapy, melatonin, acetylcholinesterase inhibitors, antipsychotic medications, and environmental intervention/behavioral modifications.

One of the environmental modifications that have been suggested by several researchers for empirical treatment of sundowning syndrome is light therapy.^73-82

A review of the available ambient light in the patient's room demonstrated that in different portions of the hospital there was a significant difference in available light that was not immediately obvious to the healthy eye.²² Increased amount of lighting in the evening hours may considerably assist the elderly patient with neurologically compromised brain in re-orienting.⁷³ It was suggested by Duckett²² to modify ambient light by matching light readings obtained from the day and evening hours.

It was reported that the placing a full-spectrum fluorescent lamp (between 2,500 and 5,000 lux) about 1 meter from the sundowning patient within his or her visual field for a couple of hours in the morning may change the patient's circadian rhythm, and make demented individual less agitated at confused. It may be achieved by turning light on while the patient is watching television or doing other daily activities.⁷⁴ In one study, the patients suffering from AD, sundown syndrome, and difficulties with sleep maintenance that were treated with bright light, have demonstrated improved sleep quality and less sundowning episodes.^75-77 In another study, Murphy and Campbell⁷⁸ have found that during the exposure to bright light there was progression in cognitive functioning in elderly individuals. In a 6-week, double-blind, placebo-controlled, crossover trial the effects of bright light therapy combined with melatonin on motor restless behavior in demented patients had been evaluated.⁷⁹ This study concluded that bright light therapy (10,000 lux bright light) has a positive effect on motor restlessness in subjects with dementia. A review of the Cochrane meta-analysis related to light therapy for managing sleep, behavior, and mood disturbances in dementia did not demonstrate the effectiveness of specific light therapy.⁸⁰ Okawa et al.⁸¹ reported positive effect of phototherapy on sleep-wake disorders in elderly demented patients. Another report demonstrated that treatment with bright light improved agitated behavior in institutionalized elderly patients.⁸²

Several studies suggested that circadian rhythm disruptions in individuals with dementia have been linked to decreased or dysregulated melatonin level and abnormalities in the SCN in this patient population, and possibly related to development of sundowning behavior.^{4,20,29-34,83-88} These studies served as a rationale for the treatment of circadian rhythm-related behavioral problem such as sundowning with melatonin. A systematic review of literature related to treatment of elderly patients with insomnia (1990-2000) revealed 12 studies with empirical treatment results for melatonin in the elderly.⁸⁹ Among these 12 studies, 6 double-blind controlled trials analyzed results by objective measurements of sleep quality. Decrease in sleep latency was registered in 4 studies. Three double-blind controlled trials found improvement in such objective characteristics of sleep quality as total sleep time, sleep efficiency, and wake time during sleep as a result of melatonin treatment, although there was no improvement in subjective sleep quality. Another 6 open-label or retrospective case studies showed a trend toward decreased sundowning and improved sleep quality.⁹⁰ Several recent studies which reflect use of melatonin specifically in patients with dementia, demonstrated that melatonin reduces sundowning behavior, nocturnal activity, decreases sleep latency, and improves quality of sleep.^89-91 De Jonghe et al.⁴⁷ performed a systematic search of the literature related to melatonin treatment in dementia which was published between 1985 and 2009. Four randomized controlled trials (RCTs), including 243 participants, and five case series including 87 participants have been analyzed. Two of the RCTs demonstrated a remarkable improvement of agitation and other manifestations of sundowning syndrome. Improvement of sundowning behavior was reported in all five case series. Based on this literature review, the effect of melatonin treatment on sleep quality and daytime functioning were inconclusive.⁴⁷ Cohen-Mansfield et al.⁴⁸ in a pilot study investigated the effect of melatonin treatment on improving sleep and reducing sundowning in 11 demented elderly nursing home residents. Results of this study showed a significant decrease in agitated behaviors during the day, as well as marked decrease in daytime sleepiness in subjects after treatment with melatonin. There was a slight decrease in sleep latency in the evening hours. The night-time sleep ratings were not remarkably changed in these patients.⁴⁸ Although Haffmans et al.⁷⁹ demonstrated that bright light therapy (10,000 lux bright light) has a positive effect on motor restlessness in demented patients, combination of melatonin with bright light does not result in any improvement of motor restless behavior in this patient population. Authors of this study hypothesized that combination of two zeitgebers (bright light and melatonin) may be "too much" in regulation of disruptive behavior. Also, it was possible that melatonin has very little effect on regulation of abnormal behavior in demented subjects. In accordance to this result, Rao et al.⁹² found that treatment with bright light modifies the circadian melatonin profile of depressed patients and healthy controls only minimally. Singer et al.⁹³ analyzed effect of melatonin on sleep disturbances in patients with AD in a double-blind placebo-controlled study of 36 centers with 156 nursing home subjects. He did not find any benefits of melatonin for treatment of insomnia in studied subjects. Therefore, based on this literature review, there is no conclusive date related to effectiveness of melatonin treatment for sundowning in demented patients.

Although acetylcholinesterase inhibitors (AChEIs) are the standard of treatment of mild and moderate AD in the United States, there is no clear evidence of their benefit in controlling behavioral symptoms, including sundowning. Data related to effect of different AChEIs on sundowning behavior are limited, and contradictory to date. Ross et al.⁹⁴ and Rogers et al.⁹⁵ suggested that donepezil might worsen nocturnal agitation and other behavioral disruptions in demented patients at night by inducing insomnia or nightmares. Rogers et al.⁹⁵ also demonstrated that 10% of patients who were treated with donepezil experienced insomnia. Insomnia as a side effect may be less prominent with galantamine and rivastigmine than with donepezil.^96,97 Nevertheless, no differences have been demonstrated in sleep measures between the galantamine and placebo in the evaluation of subjects using the Pitts-burg Sleep Quality Index.⁹⁶ There was recommendation to attenuate adverse effects of donepezil on sleep by slow dose escalation tapering, as well as by switching evening dose to morning dose.⁹⁸ Another study showed that donepezil given once a day in the morning has increased sleep efficiency and shortened sleep latency.⁹⁹ Several reports have described the effect of donepezil and other AChEIs on cognitive function, behavioral abnormalities, and sundowning in dementia with Lewy Bodies.100-102 Skjerve et al.100 reported an improvement in sundowning symptoms in 71-year-old man with clinically diagnosed dementia with Lewy bodies after treatment with donepezil. The positive results of the treatment included a marked reduction in evening activity and increase in daytime activity, as measured using the activity electronic monitoring technique, along with improved cognition and Parkinsonism.100 MacLean et al.102 reported decreased dreaming behavior in Lewy body dementia patients treated with rivastigmine. Another open-label trial showed improvement of cognitive functioning and psychosis in patient with Parkinson's disease as a result of treatment with rivastigmine.103 Stahl et al.104 evaluated results from three randomized double-blind trials of galantamine versus placebo in AD. They revealed no increase in insomnia or other sleep problems and nightmares but no reduction in sleep disturbances.104 Recent multiple RCTs demonstrated positive impact of galantamine,105 rivastigmine,106-108 and donepezil109-111 on behavioral and psychological symptoms of dementia, although they did not address specifically effect of above medications on sundowning symptoms. Currently, there is no specific data are available on treatment of sundowning syndrome with N-methyl-d-aspartate (NMDA) receptor antagonist memantine. Most of the studies are addressing common behavioral abnormalities, agitation, aggression, and psychosis in patients with AD112 However, Forchetti113 disagrees with using memantine to modify behavior, because the clinical trials did not demonstrate a significant effect on the Neuropsychiatric Inventory, the instrument used to measure changes in behavioral symptoms.

Although antipsychotics are probably the most widely used class of medications to manage symptoms of sundowning, there is limited information available in the medical literature on this particular topic. Majority of studies are reflecting use of antipsychotic medications in demented individuals for various behavioral disruptions, including psychosis and agitation, but not specifically for sundowning.114-129 Stoope et al.114 reported that >40% of family practitioners and neuropsychiatrists in Germany considered antipsychotic medications to be the drugs of choice for treatment of sundowning and other sleep disturbances in elderly demented patients. Numerous RCTs are supported the effectiveness of several antipsychotic medications (risperidone, olanzapine, aripiprazole) for the treatment of behavioral symptoms in dementia.119-123 Another report reflected the use of quetiapine for behavioral disruptions and psychosis in nursing home residents with AD.124 The Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer's Disease demonstrated that atypical antipsychotic use was associated with marked improvement in paranoid ideations, aggression, and anger.127 Tariot115 reported that antipsychotic medications exhibit modest effects on agitation in patients with severe dementia with only 15-20% effect size over placebo. He also demonstrated that about one third of patients on antipsychotic medications may experience mild sedation, which may be favorable in sleep facilitation. Another study suggested antipsychotic medications for treatment of various sleep disturbances and maladaptive behaviors at nighttime in severely demented nursing home residents.121 It was reported that there was even slight effect of antipsychotic treatment on daytime agitation, and after discontinuation of antipsychotic medications for four weeks, the global behavioral scores remained relatively stable or improved in majority of subjects.116 Standbridge128 suggested atypical antipsychotics for the treatment of sundowning and confusion in the evening, due to their sedative side effects. Parnetti129 demonstrated that atypical antipsychotics at very low dosages can be used to treat delusions, hallucinations, and paranoid ideations. Atypical antipsychotics, comparing to typical antipsychotics, have more favorable side-effect profile.² Nevertheless, its use should be carefully weighed against such life-threatening side effects as pneumonia, stroke, and death.130-132 Risperidone, is one of the commonly used agent, has been shown to decrease nocturnal agitation in nursing home residents.118 Another study demonstrated reduction of aggressiveness and wandering, as well as increase nighttime sleeping hours in demented patients treated with risperidone.117 It was recommended to reassess cognitive and behavioral status of demented patients on antipsychotic medications on a regular basis: within 3 months after treatment initiation (Canadian treatment guidelines),133 or at least every 3 to 6 months if they are outpatients.128,129 While there are no specific studies related to use of atypical antipsychotics for the treatment of sundowning, they might be considered as effective medications for this purposes, especially because these drugs are better tolerated than typical antipsychotics in the elderly patients.²

Results from the studies related to behavioral interventions for management of neurpsychiatric symptoms of dementia are inconsistent. Although it has been difficult to validate effectiveness of specific therapies for sundowning syndrome, several clinical observations has led to the emergence of various recommendations and intervention strategies. Different clinicians agree on these strategies that empirically support their usefulness.⁶² Individually tailored non-pharmacological approaches for management of behavioral disruptions, including sundowning, considered to be the first-line therapy, and should be attempted before pharmacologic interventions.133,134 The following management options has been suggested as possible interventions for behavioral abnormalities in dementia, which theoretically might be effective for sundowning as well: light therapy,^73-82,135 music therapy,136 aromatherapy,137 caregiver education,138 multisensory stimulation,139 and simulated presence therapy.140 Other recommendations include reduction of noisy background, minimizing unnecessary noise (e.g., noise from visitors, loud speakers, banging of dishes, loud staff conversation), offering simple instructions for meals and bathing, adherence to a stable daily routine.^2,62,63,141 More detailed information about a non-pharmacologic management of behavioral disruptions in AD can be found in the recently reported findings of the Resources for Advancing Alzheimer's Caregiver's Health (REACH) trial, the largest randomized controlled clinical trial to date, involving 1222 caregiver and care recipients recruited from 6 different sites in the United States.⁷⁴ Several clinicians suggest that involvement of demented patients in structured, planned activities may reduce likelihood of behavioral disruptions, including agitation, especially if these activities specifically scheduled at the times of agitation, or before beginning of behavioral abnormalities.^2,62 It was recommended to follow sleep hygiene routine, try to keep demented patient mentally occupied during the day, adhere to a structured daily schedule, and provide opportunities for physical exercise.141 Meeting physical needs, addressing pain, dyskinesias, constipation, and other physical discomfort is crucial in preventing agitation, confusion, and other behavioral disturbances in demented patients.⁶³ Redirection, reassurance, and distraction as clinical tools, can be learned by nursing staff and caregivers, and should be included in treatment plan.⁶³ It was strongly recommended for caregivers to monitor television- viewing by demented patients, especially during evening hours. Some frightening or violent events depicted on television, may be very stressful and disturbing for cognitively impaired individuals, as they may believe that these events are actually happening to them in reality. As a result, these patients may express their fears in the form of agitation, confusion, or violence.113 Creation of relaxing environment is another useful tool to ease sundown syndrome in demented patients. Listening CD with favorite music, sounds of nature (ocean waves, bird's songs, or mountain stream) might relax and calm patient down. In case of agitation due to hunger, or thirst, just offering a food, snack or something to drink may ease discomfort and reduce behavioral disruption. Talking to the patient with soft, calm voice, doing hand massage, or just holding his hand may reassure patient and diminish anxiety.⁷⁴ Other general recommendations include management of depression, feelings of guilt, sadness, grief, feelings of worthlessness, anxiety and frustration. It may also be provoked by confusion related to cognitive impairment, and induce agitation, sleep disturbances, which all may contribute to emergence or worsening of sundowning.113

There has been very little research data on prognosis of the sundown syndrome. Scarmeas et al.²⁵ reported that the presence of sundown syndrome has been associated with more rapid cognitive function deterioration in patients with early stages of AD.

Exploration of potential etiologic factors of sundowning syndrome (environmental, physiological, psychological) in each demented individual, as well as addressing modifiable factors with appropriate interventions, seems to be the best way to prevent clinical symptoms of sundowning. There is limited data in current medical literature on effective methods of prevention of sundowning syndrome in dementia. Nevertheless, it might be hypothesized, that several interventions that have been used to treat sundowning syndrome, may have been considered in prevention of this clinical phenomena. These interventions are as follows: environmental interventions/ behavioral modifications as a first line treatment,133,134 including light therapy,^73-82,135 music therapy,136 aromatherapy,137 caregiver education,138 multisensory stimulation,139 and simulated presence therapy,140 following sleep hygiene routine, adherence to a structured daily schedule, and physical exercise.141 There is no clear evidence that prophylactic use of melatonin, AChEIs, or NMDA receptor antagonist is effective in prevention of sundown syndrome development in dementia.