Integrating Extrinsic and Intrinsic Cues into a Minimal Model of Lineage Commitment for Hematopoietic Progenitors
Figure 7
Proposed paradigm for hematopoiesis.
Extrinsic (instructive) and intrinsic (stochastic) cues can both play roles in commitment of progenitor cells. In addition to classical pathways of commitment (solid arrows), bypass mechanisms have been reported for HSCs [4] (dashed green arrow) and our model suggests that this may be possible for multipotent progenitors as well (dashed purple arrow).