Issue 6, 2005
From the journal:

Natural Product Reports

An update on bioactive plant lignans

Muhammad Saleem,ab   Hyoung Ja Kim,ad   Muhammad Shaiq Alic  and  Yong Sup Lee*d  

* Corresponding authors

a Medicinal Chemistry Research Center, Division of Life Sciences, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul, Korea

b Pharmaceutical Research Center, PCSIR Laboratories Complex Karachi, Karachi, Pakistan

c HEJRIC, International Center for Chemical Sciences (ICCS), University of Karachi, Karachi, Pakistan

d Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University, 1 Hoegi-Dong, Dongdaemoon-ku, Seoul, Korea
E-mail: kyslee@khu.ac.kr
Fax: +82-2-966-3885
Tel: +82-2-961-0370

Abstract

Covering: 2000 to 2004

Lignans are a class of secondary plant metabolites produced by oxidative dimerization of two phenylpropanoid units. Although their molecular backbone consists only of two phenylpropane (C6–C3) units, lignans show an enormous structural diversity. There is a growing interest in lignans and their synthetic derivatives due to applications in cancer chemotherapy and various other pharmacological effects. This review deals with lignans possessing anticancer, antioxidant, antimicrobial, anti-inflammatory and immunosuppressive activities, and comprises the data reported in more than 100 peer-reviewed articles, so as to highlight the recently reported bioactive lignans that could be a first step towards the development of potential new therapeutic agents.

Graphical abstract: An update on bioactive plant lignans

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Article information

DOI
https://doi.org/10.1039/B514045P
Article type
Review Article
Submitted
03 Oct 2005
First published
02 Nov 2005

Nat. Prod. Rep., 2005,22, 696-716

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An update on bioactive plant lignans

M. Saleem, H. J. Kim, M. S. Ali and Y. S. Lee, Nat. Prod. Rep., 2005, 22, 696 DOI: 10.1039/B514045P

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