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Link to original content: https://doi.org/10.1038/nm880
Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells | Nature Medicine
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Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

Nature Medicine volume 9, pages 727–728 (2003)Cite this article

Abstract

Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t1/2 = 44 months) that eradication is unlikely.

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Figure 1: Extremely slow decay of the latent reservoir in patients on HAART.

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References

  1. Gulick, R.M. et al. N. Engl. J. Med. 337, 734–739 (1997).

    Article  CAS  Google Scholar 

  2. Hammer, S.M. et al. N. Engl. J. Med. 337, 725–733 (1997).

    Article  CAS  Google Scholar 

  3. Perelson, A.S. et al. Nature 387, 188–191 (1997).

    Article  CAS  Google Scholar 

  4. Chun, T.-W. et al. Nat. Med. 1, 1284–1290 (1995).

    Article  CAS  Google Scholar 

  5. Chun, T.-W. et al. Nature 387, 183–188 (1997).

    Article  CAS  Google Scholar 

  6. Finzi, D. et al. Science 278, 1295–1300 (1997).

    Article  CAS  Google Scholar 

  7. Wong, J.K. et al. Science 278, 1291–1295 (1997).

    Article  CAS  Google Scholar 

  8. Chun, T.W. et al. Proc. Natl. Acad. Sci. USA 94, 13193–13197 (1997).

    Article  CAS  Google Scholar 

  9. Finzi, D. et al. Nat. Med. 5, 512–517 (1999).

    Article  CAS  Google Scholar 

  10. Blankson, J.N. Annu. Rev. Med. 53, 557–593 (2002).

    Article  CAS  Google Scholar 

  11. Zhang, L. et al. N. Engl. J. Med. 340, 1605–1613 (1999).

    Article  CAS  Google Scholar 

  12. Ramratnam, B. et al. Nat. Med. 6, 82–85 (2000).

    Article  CAS  Google Scholar 

  13. Dornadula, G. et al. JAMA 282, 1627–1632 (1999).

    Article  CAS  Google Scholar 

  14. Ruff, C.T. et al. J. Virol. 76, 9481–9492 (2002).

    Article  CAS  Google Scholar 

  15. Hermankova, M. et al. JAMA 286, 196–207 (2001).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank S. Barnett for coordinating patient visits. This work was supported by National Institutes of Health grant AI43222 to R.F.S. and by a grant from the Doris Duke Charitable Foundation.

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Authors and Affiliations

  1. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, 21205, Maryland, USA

    Janet D Siliciano, Joleen Kajdas, Thomas C Quinn & Robert F Siliciano

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892, Maryland, USA

    Diana Finzi & Thomas C Quinn

  3. Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, 21205, Maryland, USA

    Karen Chadwick & Joseph B Margolick

  4. Department of Medicine, University of Toronto, Toronto, M5B 1L6, Ontario, Canada

    Colin Kovacs

  5. Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, 21205, Maryland, USA

    Stephen J Gange

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  1. Janet D Siliciano
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Correspondence to Robert F Siliciano.

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Siliciano, J., Kajdas, J., Finzi, D. et al. Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells. Nat Med 9, 727–728 (2003). https://doi.org/10.1038/nm880

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