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Link to original content: https://doi.org/10.1038/85191
The evolution of brain activation during temporal processing | Nature Neuroscience
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The evolution of brain activation during temporal processing

Nature Neuroscience volume 4, pages 317–323 (2001)Cite this article

Abstract

Timing is crucial to many aspects of human performance. To better understand its neural underpinnings, we used event-related fMRI to examine the time course of activation associated with different components of a time perception task. We distinguished systems associated with encoding time intervals from those related to comparing intervals and implementing a response. Activation in the basal ganglia occurred early, and was uniquely associated with encoding time intervals, whereas cerebellar activation unfolded late, suggesting an involvement in processes other than explicit timing. Early cortical activation associated with encoding of time intervals was observed in the right inferior parietal cortex and bilateral premotor cortex, implicating these systems in attention and temporary maintenance of intervals. Late activation in the right dorsolateral prefrontal cortex emerged during comparison of time intervals. Our results illustrate a dynamic network of cortical-subcortical activation associated with different components of temporal information processing.

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Figure 1: Trial events in the time perception (a), pitch perception (b), and control (c) conditions.
Figure 2: Temporal relationship among the trial events, acquisition of images and hypothetical hemodynamic response functions to different task components.
Figure 3: Mean (± standard error of mean) reaction time and percent correct for the time perception (a, b) and the pitch perception (c, d) conditions.
Figure 4: Activation foci in the basal ganglia (a), cerebellum (b), and pre-supplementary motor area/anterior cingulate (c) resulting from subtraction of the control (C) condition from the time (T) and the pitch (P) perception conditions at 2.5, 5.0, 7.5 and 10.0 s after trial onset.
Figure 5: Activation foci in the lateral surface of the left and right hemispheres denote greater activation for the time (T) and the pitch (P) perception conditions relative to the control (C) condition at 2.5, 5.0, 7.5 and 10.0 s after trial onset.
Figure 6: Activation foci in the basal ganglia, insula/frontal operculum and dorsal lateral prefrontal cortex resulting from greater activation for the time (T) relative to the pitch (P) perception conditions at 2.5, 5.0, 7.5 and 10.0 s after trial onset.

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Acknowledgements

This study was funded in part by grants from the Department of Veterans Affairs and National Foundation for Functional Brain Imaging (D.L.H.), the National Institutes of Health (P01 MH51358, R01 MH57836, M01 RR00058) and W.M. Keck Foundation (S.M.R.). We thank R. Cox, E. DeYoe, S. Durgerian, R. Lee, G. Mallory, L. Mead, J. Neitz and B. Ward for their assistance.

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Author notes

  1. Stephen M. Rao and Deborah L. Harrington: These authors contributed equally to this work

Authors and Affiliations

  1. Department of Neurology, Medical College of Wisconsin, Milwaukee, 53226, Wisconsin, USA

    Stephen M. Rao, Andrew R. Mayer & Deborah L. Harrington

  2. Department of Veterans Affairs, Albuquerque, 87108, New Mexico, USA

    Deborah L. Harrington

  3. Department of Neurology, University of New Mexico, Albuquerque, 87113, New Mexico, USA

    Deborah L. Harrington

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  1. Stephen M. Rao
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Correspondence to Deborah L. Harrington.

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Rao, S., Mayer, A. & Harrington, D. The evolution of brain activation during temporal processing. Nat Neurosci 4, 317–323 (2001). https://doi.org/10.1038/85191

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