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Link to original content: https://doi.org/10.1038/349117a0
The GTPase superfamily: conserved structure and molecular mechanism | Nature
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The GTPase superfamily: conserved structure and molecular mechanism

Nature volume 349, pages 117–127 (1991)Cite this article

Abstract

GTPases are conserved molecular switches, built according to a common structural design. Rapidly accruing knowledge of individual GTPases—crystal structures, biochemical properties, or results of molecular genetic experiments—support and generate hypotheses relating structure to function in other members of the diverse family of GTPases.

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Authors and Affiliations

  1. Departments of Pharmacology and Medicine and the Cardiovascular Research Institute, University of California, San Francisco, California, 94143-0450, USA

    Henry R. Bourne

  2. formerly at the University of California and the CETUS Corporation and is now at the Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142, USA

    David A. Sanders

  3. Department of Molecular Biology, CETUS Corporation, Emeryville, California, 94608, USA

    Frank McCormick

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Bourne, H., Sanders, D. & McCormick, F. The GTPase superfamily: conserved structure and molecular mechanism. Nature 349, 117–127 (1991). https://doi.org/10.1038/349117a0

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