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Link to original content: https://doi.org/10.1023/A:1020546615229
TNF-Induced Signaling in Apoptosis | Journal of Clinical Immunology Skip to main content

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TNF-Induced Signaling in Apoptosis

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Abstract

Out of the almost 17 members of the TNF superfamily, TNF is probably the most potent inducer of apoptosis. TNF activates both cell-survival and cell-death mechanisms simultaneously. Activation of NF-kB-dependent genes regulates the survival and proliferative effects pf TNF, whereas activation of caspases regulates the apoptotic effects. TNF-induced apoptosis is mediated primarily through the activation of type I receptors, the death domain of which recruits more than a dozen different signaling proteins, which together are considered part of an apoptotic cascade. This cascade does not, however, account for the role of reactive oxygen intermediates, ceramide, phospholipases, and serine proteases which are also inplicated in TNF-induced apoptosis. This cascade also does not explain how type II TNF receptors which lack the death domain, induce apoptosis. Nevertheless, this review of apoptosis signaling will be limited to those proteins that makeup the cascade.

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  1. School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India

    Pramod C. Rath

  2. Cytokine Research Laboratory, Department of Molecular Oncology, The University of Texas M. D. Anderson Cancer Center, Box 143, 1515, Holcombe Boulevard, Houston, Texas, 77030

    Pramod C. Rath & Bharat B. Aggarwal

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Rath, P.C., Aggarwal, B.B. TNF-Induced Signaling in Apoptosis. J Clin Immunol 19, 350–364 (1999). https://doi.org/10.1023/A:1020546615229

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