Abstract
In this work, we present a faceted-search based approach for visualization of anatomy by combining a three dimensional digital atlas with an anatomy ontology. Specifically, our approach provides a drill-down search interface that exposes the relevant pieces of information (obtained by searching the ontology) for a user query. Hence, the user can produce visualizations starting with minimally specified queries. Furthermore, by automatically translating the user queries into the controlled terminology our approach eliminates the need for the user to use controlled terminology. We demonstrate the scalability of our approach using an abdominal atlas and the same ontology. We implemented our visualization tool on the opensource 3D Slicer software. We present results of our visualization approach by combining a modified Foundational Model of Anatomy (FMA) ontology with the Surgical Planning Laboratory (SPL) Brain 3D digital atlas, and geometric models specific to patients computed using the SPL brain tumor dataset.
Similar content being viewed by others
Notes
In this work, we use displayable and geometric models interchangeably.
The gene expression data is however stored in an online server and it is not clear to the authors how this information can be obtained in a machine readable file for integrating with the faceted visualizer. Our discussion is therefore limited to the anatomical structures alone.
References
3DSlicer (2012). 3D Slicer. http://www.slicer.org/.
Allen Human Brain Atlas (2013). http://www.brain-map.org/.
Blezek, D., & Miller, J.V. (2010). Fast affine registration. http://www.slicer.org/slicerWiki/index.php/Modules:AffineRegistration-Documentation-3.6.
Bug, W.J., Ascoli, G.A., Grethe, J.S., Gupta, A., Fennema-Notestine, C., Laird, A.R., Larson, S.D., Rubin, D., Sheperd, G.M., Turner, J.A., Martone, M.E. (2008). The NIFSTD and BIRNLex vocabularies: building comprehensive ontologies for neuroscience. Neuroinformatics, 6(3), 175–194.
Curtell, E., Robbins, D., Dumais, S., Sarin, R. (2006). Fast, flexible filtering with Phlat. In Proceedings of CHI (pp. 261–270).
Estevez, M., Lindgren, K., Bergethon, P. (2010). A novel three-dimensional tool for teaching human neuroanatomy. Anatomy Science Education, 3(6), 309–317.
Fedorov, A., Beichel, R., Kalpathy-Cramer, J., Finet, J., Fillion-Robin, J., Pujol, S., Bauer, C., Jennings, D., Fennessy, F., Sonka, M., Buatti, J., Aylward, S., Miller, J., Pieper, S., Kikinis, R. (2012). 3D Slicer as an image computing platform for the quantitative imaging network. Magnetic Resonance Imaging, 30(9), 1323–1341.
Golland, P., Kikinis, R., Halle, M., Umans, C., Grimson, W., Shenton, M., Richolt, J. (1999). AnatomyBrowser: a novel approach to visualization and integration of medical information. Computer Aided Surgery, 4(3), 129–143.
Hearst, M., & Soica, E. (2009). NLP support for faceted navigation in scholarly collections. In Proceedings of 2009 workshop on text and citation analysis for scholarly digital libraries (pp. 62–70).
Hon̈he, K., Pflesser, B., Riemer, M., Schiemann, T., Schubert, R., Tiede, U. (1995). A new representation of knowledge concerning human anatomy and function. Nature Medicine, 1(6), 506–5011.
Hon̈he, A.P.K., Pflesser, B., Richter, E., Reimer, M., Scheimann, T., Schubert, R., Schumacher, U., Tiede, U. (2001). Creating a high-resolution spatial/symbolic model of the inner organs based on the visbile human. Medical Image Analysis, 5(3), 221–228.
Jinx (2012). Jinx. http://www.bioontology.org/Jinx.
Jonguet, C., Shah, N., Musen, M.A. (2009). The open biomedical annotator. In AMIA summit on translational bioinformatics (pp. 56–60).
Kaus, M., Warfield, S., Nabavi, A., Black, P., Jolesz, J., Kikinis, R. (2007). Automated segmentation of brain tumors.
Keator, D., Grethe, J., Marcus, D., Ozyurt, B., Gadde, S., Murphy, S., Pieper, S., Greve, D., Notestine, R., Bockholt, H., Papadopoulos, P. (2008). A national human neuroimaging collaboratory enabled by the biomedical informatics research network. IEEE Transactions on Information Technology in Biomedicine, 12(2), 162–172.
Kikinis, R. (1996). A digital brain atlas for surgical planning, model-driven segmentation, and teaching. IEEE Transaction on Visualization and Computer Graphics, 2(3), 232–241.
Koren, J., Zhang, Y., Liu, X. (2008). Personalized interactive faceted search. In Proceedings of international conference on world wide web.
Kub, A., Prohaska, S., Meyer, B., Rybak, J., Hege, H.C. (2008). Ontology-based visualization of hierarchical neuroanatomical structures. In Eurographics workshop on visual computing for biomedicine.
Mattes, D., Haynor, D., Vesselle, H., Eubank, W. (2003). PET-CT image registration in the chest using free-form deformations. IEEE Transactions on Medical Imaging, 22(1), 120–128.
Miller, J.V., & Lorenson, B. (2008). Deformable B spline registration. http://www.slicer.org/slicerWiki/index.php/Slicer3:Module:Deformable_BSpline_registration.
Moore, E., Poliakov, A., Lincoln, P., Brinkley, J. (2007). MindSeer: a portable and extensible tool for visualization of structural and functional neuroimaging data. BMC Bioinformatics, 8, 389–401.
NCBO (2012). National Center for Biomedical Ontologies. http://www.bioontology.org/technology.
Petersson, H., Sinkvist, D., Wang, C., Smedby, O. (2009). Web-based interactive 3D visualization as a tool for improved anatomy learning. Anatomy Science Education, 2, 61–68.
Pieper, S., Brown, G., Kennedy, D., Martone, M., Boline, J., Ozyurt, B., Plesniak, W., Halle, M., Tang, A., Talos, F. (2008). Query atlas. http://www.slicer.org/slicerWiki/index.php/Slicer3:Module:QueryAtlas.
Pohl, K., Bouix, S., Nakamura, M., Rohfling, T., McCarley, R., Kikinis, R., Grimson, W., Shenton, M., Wells, W.A. (2007). A hierarchical algorithm for MR brain image parcellation. IEEE Transactions on Medical Imaging, 26(9), 1201–1212.
Ranabahu, A., Parikh, P., Panahiazar, M., Sheth, A., Logan-Klumpler, F. (2011). Kino: a generic document management system for biologists using SA-REST and faceted search. In IEEE international conference on semantic computing.
Rosse, C., & Mejino, J. Jr. (2003). A reference ontology for biomedical informatics: the foundational model of anatomy. Journal of Biomedical Informatics, 36, 478–500.
Rubin, D., Bashir, Y., Grossman, D., Dev, P., Musen, M. (2004). Linking ontologies with three-dimensional models of anatomy to predict the effects of penetrating injuries. In Proceedings international conference of the IEEE EMBS (pp. 3128–3131.)
Rubin, D., Talos, I.F., Halle, M., Musen, M., Kikinis, R. (2009). Computational neuroanatomy: ontology-based representation of neural components and connectivity. BMC Bioinformatics, 10(S-2), S3.
Schroeder, W., Martin, K., Lorenson, B. (2006). Visualization toolkit, 4th edn. Kitware Inc.
Talos, I.F., Jakab, M., Kikinis, R. (2008). SPL abdominal atlas. http://www.spl.harvard.edu/publications/item/view/1266.
Talos, I.F., Wald, L., Halle, M., Kikinis, R. (2009). Multimodal SPL brain atlas data. http://www.spl.harvard.edu/publications/item/view/1565.
Teevan, J., Dumais, S., Gutt, Z. (2008). Challenges for supporting faceted search in large, heterogeneous corpora like the web. In Second workshop on human-computer interaction and information retrieval.
Terminizer (2009). Terminizer. http://terminizer.org/.
Turner, J., Mejino, J., Brinkley, J., Detwiler, L., Lee, H., Martone, M., Rubin, D.L. (2010). Application of neuroanatomical ontologies for neuroimaging data annotation. Frontiers in Neuroinformatics, 4(10). doi:10.3389/finf.2010.00010.
Veeraraghavan, H., & Miller, J.V. (2010). Grow Cut segmentation. http://www.slicer.org/slicerWiki/index.php/Modules:GrowCutSegmentation-Documentation-3.6.
Veeraraghavan, H., Miller, J., Halle, M. (2012). Faceted visualizer. http://www.slicer.org/slicerWiki/index.php/Documentation/4.1/Modules/FacetedVisualizer.
Vezhnevets, V., & Konouchine, V. (2005). GrowCut - interactive multi-label N-D image segmentation. In Proceedings graphicon (pp. 150–156).
Acknowledgments
This work was supported in part by the NIH NCRR NAC P41-RR13218 and is part of the National Alliance for Medical Image Computing (NAMIC) funded by the National Institutes of Health through the NIH Roadmap for Medical Research, Grant U54 EB005149. The authors also thank the reviewers whos’ comments and suggestions greatly helped to improve the manuscript.
Conflict of interest
The authors declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Appendix A
Appendix A
Rights and permissions
About this article
Cite this article
Veeraraghavan, H., Miller, J.V. Faceted Visualization of Three Dimensional Neuroanatomy By Combining Ontology with Faceted Search. Neuroinform 12, 245–259 (2014). https://doi.org/10.1007/s12021-013-9202-5
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12021-013-9202-5