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Link to original content: https://doi.org/10.1007/s11910-018-0860-4
GBA-Associated Parkinson’s Disease and Other Synucleinopathies | Current Neurology and Neuroscience Reports Skip to main content

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GBA-Associated Parkinson’s Disease and Other Synucleinopathies

  • Genetics (V Bonifati, Section Editor)
  • Published:
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Abstract

Purpose of Review

GBA mutations are the most common known genetic cause of Parkinson’s disease (PD). Its biological pathway may be important in idiopathic PD, since activity of the enzyme encoded by GBA, glucocerebrosidase, is reduced even among PD patients without GBA mutations. This article describes the structure and function of GBA, reviews recent literature on the clinical phenotype of GBA PD, and suggests future directions for research, counseling, and treatment.

Recent Findings

Several longitudinal studies have shown that GBA PD has faster motor and cognitive progression than idiopathic PD and that this effect is dose dependent. New evidence suggests that GBA mutations may be important in multiple system atrophy. Further, new interventional studies focusing on GBA PD are described. These studies may increase the interest of PD patients and caregivers in genetic counseling.

Summary

GBA mutation status may help clinicians estimate PD progression, though mechanisms underlying GBA and synucleinopathy require further understanding.

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Authors and Affiliations

  1. Montréal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada

    Ziv Gan-Or

  2. Department of Human Genetics, McGill University, Montréal, QC, Canada

    Ziv Gan-Or

  3. Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada

    Ziv Gan-Or

  4. Department of Neurology, College of Physicians and Surgeons, Columbia University Medical Center, 710 West 168th street, New York, NY, USA

    Christopher Liong & Roy N. Alcalay

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  1. Ziv Gan-Or
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  2. Christopher Liong
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Correspondence to Roy N. Alcalay.

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Conflict of Interest

Ziv Gan-Or is supported by research grants from the Michael J. Fox Foundation, the Canadian Consortium on Neurodegeneration in Aging (CCNA), the Canadian Glycomics Network (GlycoNet), and the Canada First Research Excellence Fund, awarded to McGill University for the Healthy Brains for Healthy Lives (HBHL) program. Dr. Gan-Or is consulting for Sanofi and for Lysosomal Therapeutics Inc. (LTI).

Christopher Liong declares no potential conflicts of interest.

Roy N. Alcalay is supported by the Parkinson’s Disease Foundation, the Michael J. Fox Foundation, and the National Institutes of Health.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Gan-Or, Z., Liong, C. & Alcalay, R.N. GBA-Associated Parkinson’s Disease and Other Synucleinopathies. Curr Neurol Neurosci Rep 18, 44 (2018). https://doi.org/10.1007/s11910-018-0860-4

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