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Link to original content: https://doi.org/10.1007/978-94-007-4719-7_1
Introduction to Purinergic Signalling in the Brain | SpringerLink
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Introduction to Purinergic Signalling in the Brain

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Glioma Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 986))

Abstract

ATP is a cotransmitter with glutamate, noradrenaline, GABA, acetylcholine and dopamine in the brain. There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the brain on both neurons and glial cells. Adenosine receptors play a major role in presynaptic neuromodulation, while P2X ionotropic receptors are involved in fast synaptic transmission and synaptic plasticity. P2Y G protein-coupled receptors are largely involved in presynaptic activities, as well as mediating long-term (trophic) signalling in cell proliferation, differentiation and death during development and regeneration. Both P1 and P2 receptors participate in neuron-glial interactions. Purinergic signalling is involved in control of cerebral vascular tone and remodelling and has been implicated in learning and memory, locomotor and feeding behaviour and sleep. There is increasing interest in the involvement of purinergic signalling in the pathophysiology of the CNS, including trauma, ischaemia, epilepsy, neurodegenerative diseases, neuropsychiatric and mood disorders, and cancer, including gliomas.

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Abbreviations

ACh:

Acetylcholine

ADP:

Adenosine diphosphate

ATP:

Adenosine 5′-triphosphate

bFGF:

Basic fibroblast growth factor

CNS:

Central nervous system

CREB:

cAMP response element-binding protein

E-NPPs:

Ecto-nucleotide pyrophosphatase/phosphodiesterases

E-NTPDases:

Ecto-nucleoside triphosphate diphosphohydrolase

GABA:

γ-Amino butyric acid

IL-6:

Interleukin-6

NA:

Noradrenaline

UDP:

Uridine diphosphate

UTP:

Uridine 5′-triphosphate

TMZ:

Temozolomide

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  1. Autonomic Neuroscience Centre, University College Medical School, Royal Free Campus, Rowland Hill Street, NW3 2PF, London, UK

    Geoffrey Burnstock

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  1. Geoffrey Burnstock
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Correspondence to Geoffrey Burnstock .

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  1. , Biochemistry, Nencki Institute of Experimental Biology, Pasteur 3, Warsaw, 02-093, Poland

    Jolanta Barańska

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Burnstock, G. (2013). Introduction to Purinergic Signalling in the Brain. In: Barańska, J. (eds) Glioma Signaling. Advances in Experimental Medicine and Biology, vol 986. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4719-7_1

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