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Link to original content: https://doi.org/10.1007/3-540-30773-7_7
Rotavirus Proteins: Structure and Assembly | SpringerLink
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Rotavirus Proteins: Structure and Assembly

  • Chapter
Reoviruses: Entry, Assembly and Morphogenesis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 309))

Abstract

Rotavirus is a major pathogen of infantile gastroenteritis. It is a large and complex virus with a multilayered capsid organization that integrates the deter minants of host specificity, cell entry, and the enzymatic functions necessary for endogenous transcription of the genome that consists of 11 dsRNA segments. These segments encode six structural and six nonstructural proteins. In the last few years, there has been substantial progress in our understanding of both the structural and functional aspects of a variety of molecular processes involved in the replication of this virus. Studies leading to this progress using of a variety of structural and biochemical techniques including the recent application of RNA interference technology have uncovered several unique and intriguing features related to viral morphogenesis. This review focuses on our current understanding of the structural basis of the molecular processes that govern the replication of rotavirus.

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Authors and Affiliations

  1. Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, 77030, USA

    J. B. Pesavento & B. V. Venkataram Prasad

  2. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, 77030, USA

    S. E. Crawford & M. K. Estes

Authors
  1. J. B. Pesavento
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  2. S. E. Crawford
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  3. M. K. Estes
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  4. B. V. Venkataram Prasad
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Correspondence to B. V. Venkataram Prasad .

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  1. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK

    Polly Roy M.Sc., Ph.D.

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Pesavento, J.B., Crawford, S.E., Estes, M.K., Venkataram Prasad, B.V. (2006). Rotavirus Proteins: Structure and Assembly. In: Roy, P. (eds) Reoviruses: Entry, Assembly and Morphogenesis. Current Topics in Microbiology and Immunology, vol 309. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-30773-7_7

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