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Link to original content: https://assays.cancer.gov/CPTAC-824
| Official Gene Symbol | Other Aliases |
|---|---|
| MAP3K1 | MAPKKK1, MEKK, MEKK1 |
| Sequence Length (AA) | Molecular Weight (Da) |
|---|---|
| 1512 | 164470 |
| Protein Name |
|---|
| Mitogen-activated protein kinase kinase kinase 1 |
| Sources | |
|---|---|
|
UniProt PhosphoSitePlus ® GeneCards |
Human Protein Atlas |
| 10 | 20 | 30 | 40 | 50 |
| MAAAAGNRAS | SSGFPGARAT | SPEAGGGGGA | LKASSAPAAA | AGLLREAGSG |
| 60 | 70 | 80 | 90 | 100 |
| GRERADWRRR | QLRKVRSVEL | DQLPEQPLFL | AASPPASSTS | PSPEPADAAG |
| 110 | 120 | 130 | 140 | 150 |
| SGTGFQPVAV | PPPHGAASRG | GAHLTESVAA | PDSGASSPAA | AEPGEKRAPA |
| 160 | 170 | 180 | 190 | 200 |
| AEPSPAAAPA | GREMENKETL | KGLHKMDDRP | EERMIREKLK | ATCMPAWKHE |
| 210 | 220 | 230 | 240 | 250 |
| WLERRNRRGP | VVVKPIPVKG | DGSEMNHLAA | ESPGEVQASA | ASPASKGRRS |
| 260 | 270 | 280 | 290 | 300 |
| PSPGNSPSGR | TVKSESPGVR | RKRVSPVPFQ | SGRITPPRRA | PSPDGFSPYS |
| 310 | 320 | 330 | 340 | 350 |
| PEETNRRVNK | VMRARLYLLQ | QIGPNSFLIG | GDSPDNKYRV | FIGPQNCSCA |
| 360 | 370 | 380 | 390 | 400 |
| RGTFCIHLLF | VMLRVFQLEP | SDPMLWRKTL | KNFEVESLFQ | KYHSRRSSRI |
| 410 | 420 | 430 | 440 | 450 |
| KAPSRNTIQK | FVSRMSNSHT | LSSSSTSTSS | SENSIKDEEE | QMCPICLLGM |
| 460 | 470 | 480 | 490 | 500 |
| LDEESLTVCE | DGCRNKLHHH | CMSIWAEECR | RNREPLICPL | CRSKWRSHDF |
| 510 | 520 | 530 | 540 | 550 |
| YSHELSSPVD | SPSSLRAAQQ | QTVQQQPLAG | SRRNQESNFN | LTHYGTQQIP |
| 560 | 570 | 580 | 590 | 600 |
| PAYKDLAEPW | IQVFGMELVG | CLFSRNWNVR | EMALRRLSHD | VSGALLLANG |
| 610 | 620 | 630 | 640 | 650 |
| ESTGNSGGSS | GSSPSGGATS | GSSQTSISGD | VVEACCSVLS | MVCADPVYKV |
| 660 | 670 | 680 | 690 | 700 |
| YVAALKTLRA | MLVYTPCHSL | AERIKLQRLL | QPVVDTILVK | CADANSRTSQ |
| 710 | 720 | 730 | 740 | 750 |
| LSISTLLELC | KGQAGELAVG | REILKAGSIG | IGGVDYVLNC | ILGNQTESNN |
| 760 | 770 | 780 | 790 | 800 |
| WQELLGRLCL | IDRLLLEFPA | EFYPHIVSTD | VSQAEPVEIR | YKKLLSLLTF |
| 810 | 820 | 830 | 840 | 850 |
| ALQSIDNSHS | MVGKLSRRIY | LSSARMVTTV | PHVFSKLLEM | LSVSSSTHFT |
| 860 | 870 | 880 | 890 | 900 |
| RMRRRLMAIA | DEVEIAEAIQ | LGVEDTLDGQ | QDSFLQASVP | NNYLETTENS |
| 910 | 920 | 930 | 940 | 950 |
| SPECTVHLEK | TGKGLCATKL | SASSEDISER | LASISVGPSS | STTTTTTTTE |
| 960 | 970 | 980 | 990 | 1000 |
| QPKPMVQTKG | RPHSQCLNSS | PLSHHSQLMF | PALSTPSSST | PSVPAGTATD |
| 1010 | 1020 | 1030 | 1040 | 1050 |
| VSKHRLQGFI | PCRIPSASPQ | TQRKFSLQFH | RNCPENKDSD | KLSPVFTQSR |
| 1060 | 1070 | 1080 | 1090 | 1100 |
| PLPSSNIHRP | KPSRPTPGNT | SKQGDPSKNS | MTLDLNSSSK | CDDSFGCSSN |
| 1110 | 1120 | 1130 | 1140 | 1150 |
| SSNAVIPSDE | TVFTPVEEKC | RLDVNTELNS | SIEDLLEASM | PSSDTTVTFK |
| 1160 | 1170 | 1180 | 1190 | 1200 |
| SEVAVLSPEK | AENDDTYKDD | VNHNQKCKEK | MEAEEEEALA | IAMAMSASQD |
| 1210 | 1220 | 1230 | 1240 | 1250 |
| ALPIVPQLQV | ENGEDIIIIQ | QDTPETLPGH | TKAKQPYRED | TEWLKGQQIG |
| 1260 | 1270 | 1280 | 1290 | 1300 |
| LGAFSSCYQA | QDVGTGTLMA | VKQVTYVRNT | SSEQEEVVEA | LREEIRMMSH |
| 1310 | 1320 | 1330 | 1340 | 1350 |
| LNHPNIIRML | GATCEKSNYN | LFIEWMAGGS | VAHLLSKYGA | FKESVVINYT |
| 1360 | 1370 | 1380 | 1390 | 1400 |
| EQLLRGLSYL | HENQIIHRDV | KGANLLIDST | GQRLRIADFG | AAARLASKGT |
| 1410 | 1420 | 1430 | 1440 | 1450 |
| GAGEFQGQLL | GTIAFMAPEV | LRGQQYGRSC | DVWSVGCAII | EMACAKPPWN |
| 1460 | 1470 | 1480 | 1490 | 1500 |
| AEKHSNHLAL | IFKIASATTA | PSIPSHLSPG | LRDVALRCLE | LQPQDRPPSR |
| 1510 | 1512 | |||
| ELLKHPVFRT | TW |
Data source: UniProt
Uniprot Database Entry PhosphoSitePlus ®
loading
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y4 (1+) | 12.8 | 9.2 | 7.9 | 13.3 | 8.7 | 6.1 | 18.5 | 12.7 | 10 | 15 | 15 | 15 |
| y5 (1+) | 12.8 | 4.7 | 5.5 | 12.2 | 6.1 | 6.9 | 17.7 | 7.7 | 8.8 | 15 | 15 | 15 |
| y6 (1+) | 8.9 | 6.7 | 5.1 | 10 | 5.9 | 4.9 | 13.4 | 8.9 | 7.1 | 15 | 15 | 15 |
| y7 (1+) | 7.7 | 4.4 | 3.2 | 9.7 | 5.9 | 3.2 | 12.4 | 7.4 | 4.5 | 15 | 15 | 15 |
| y8 (1+) | 5.5 | 2.6 | 5.6 | 7.6 | 4.6 | 5.5 | 9.4 | 5.3 | 7.8 | 15 | 15 | 15 |
| y9 (1+) | 5.8 | 2.4 | 2.1 | 8.3 | 3.2 | 3.6 | 10.1 | 4 | 4.2 | 15 | 15 | 15 |
| y11 (1+) | 12.4 | 9.2 | 6 | 11.4 | 9.8 | 8.6 | 16.8 | 13.4 | 10.5 | 15 | 15 | 15 |
| sum | 4 | 1.8 | 2.4 | 6.5 | 3.1 | 3.2 | 7.6 | 3.6 | 4 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 10.5 | 5.9 | 9.1 | 17.2 | 10 | 10.5 | 20.2 | 11.6 | 13.9 | 15 | 15 | 15 |
| y4 (1+) | 19.3 | 11.2 | 9 | 22 | 11.9 | 11.4 | 29.3 | 16.3 | 14.5 | 15 | 15 | 15 |
| y5 (1+) | 13 | 10.9 | 5 | 13.4 | 11.4 | 9.6 | 18.7 | 15.8 | 10.8 | 15 | 15 | 15 |
| y6 (1+) | 12.8 | 3.9 | 5.5 | 12.6 | 9 | 7.3 | 18 | 9.8 | 9.1 | 15 | 15 | 15 |
| y7 (1+) | 6.8 | 9 | 5.7 | 11.2 | 13 | 6.4 | 13.1 | 15.8 | 8.6 | 15 | 15 | 15 |
| y8 (1+) | 14.9 | 7.7 | 5.7 | 19.8 | 10 | 6 | 24.8 | 12.6 | 8.3 | 15 | 15 | 15 |
| y9 (1+) | 8.8 | 4 | 4.1 | 11.9 | 6.5 | 6.4 | 14.8 | 7.6 | 7.6 | 15 | 15 | 15 |
| b3 (1+) | 17.5 | 7.3 | 11.2 | 14.3 | 12.9 | 15.7 | 22.6 | 14.8 | 19.3 | 15 | 15 | 15 |
| sum | 4.7 | 3.8 | 3.4 | 9.5 | 7.2 | 6.2 | 10.6 | 8.1 | 7.1 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 9.1 | 10.5 | 8.9 | 13 | 10.9 | 8.8 | 15.9 | 15.1 | 12.5 | 15 | 15 | 15 |
| y4 (1+) | 9 | 7.3 | 8.2 | 9.6 | 7.2 | 8.7 | 13.2 | 10.3 | 12 | 15 | 15 | 15 |
| y5 (1+) | 9.9 | 5.8 | 8.6 | 10.2 | 4.2 | 9 | 14.2 | 7.2 | 12.4 | 15 | 15 | 15 |
| y6 (1+) | 14.7 | 8.5 | 8.3 | 16.8 | 12.8 | 8.2 | 22.3 | 15.4 | 11.7 | 15 | 15 | 15 |
| y7 (1+) | 13.3 | 12.7 | 10.4 | 15.2 | 9.7 | 10.8 | 20.2 | 16 | 15 | 15 | 15 | 15 |
| sum | 5.8 | 3.1 | 4.8 | 7.5 | 3 | 4.3 | 9.5 | 4.3 | 6.4 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 10.9 | 9.3 | 9.4 | 12.4 | 10.1 | 10.3 | 16.5 | 13.7 | 13.9 | 15 | 15 | 15 |
| y4 (1+) | 13 | 3.8 | 10.3 | 17.3 | 3.7 | 7.8 | 21.6 | 5.3 | 12.9 | 15 | 15 | 15 |
| y5 (1+) | 9.7 | 8.5 | 8.9 | 14.5 | 8.2 | 9.8 | 17.4 | 11.8 | 13.2 | 15 | 15 | 15 |
| y6 (1+) | 15.2 | 10.5 | 11.5 | 21.5 | 11.2 | 11.7 | 26.3 | 15.4 | 16.4 | 15 | 15 | 15 |
| sum | 6.9 | 3.2 | 4.3 | 9.8 | 2.6 | 4.4 | 12 | 4.1 | 6.2 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y10 (1+) | 7.2 | 5.8 | 4 | 6 | 5.8 | 4.6 | 9.4 | 8.2 | 6.1 | 15 | 15 | 15 |
| y9 (1+) | 8.2 | 5.5 | 7.6 | 7.4 | 4.2 | 7.2 | 11 | 6.9 | 10.5 | 15 | 15 | 15 |
| y8 (1+) | 8.2 | 6.1 | 4.5 | 10.6 | 6 | 5.3 | 13.4 | 8.6 | 7 | 15 | 15 | 15 |
| y7 (1+) | 10 | 5.6 | 6.1 | 10.5 | 6 | 6.8 | 14.5 | 8.2 | 9.1 | 15 | 15 | 15 |
| y6 (1+) | 17.1 | 7.2 | 8.4 | 16.6 | 10.1 | 9 | 23.8 | 12.4 | 12.3 | 15 | 15 | 15 |
| y5 (1+) | 7.7 | 6.8 | 6.4 | 9.9 | 6.1 | 8.2 | 12.5 | 9.1 | 10.4 | 15 | 15 | 15 |
| y4 (1+) | 8.7 | 2.5 | 3.3 | 10.5 | 4.2 | 4 | 13.6 | 4.9 | 5.2 | 15 | 15 | 15 |
| y3 (1+) | 10.2 | 10.1 | 7.8 | 14.3 | 9.5 | 7.4 | 17.6 | 13.9 | 10.8 | 15 | 15 | 15 |
| sum | 3.9 | 3 | 2.2 | 4.1 | 2.5 | 3 | 5.7 | 3.9 | 3.7 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 25.6 | 9.1 | 10.9 | 21.8 | 12.7 | 15.2 | 33.6 | 15.6 | 18.7 | 15 | 15 | 15 |
| y4 (1+) | 17.7 | 14.3 | 11.2 | 28.3 | 14.4 | 13.2 | 33.4 | 20.3 | 17.3 | 15 | 15 | 15 |
| y5 (1+) | 15.4 | 14.3 | 8.6 | 20 | 17 | 12 | 25.2 | 22.2 | 14.8 | 15 | 15 | 15 |
| y6 (1+) | 12.8 | 8.1 | 7.7 | 12.7 | 9.3 | 7.8 | 18 | 12.3 | 11 | 15 | 15 | 15 |
| y7 (1+) | 12.5 | 5.2 | 10.7 | 14.2 | 10 | 9.9 | 18.9 | 11.3 | 14.6 | 15 | 15 | 15 |
| y8 (1+) | 21 | 11.7 | 7.7 | 17.7 | 11.6 | 9.1 | 27.5 | 16.5 | 11.9 | 15 | 15 | 15 |
| y9 (1+) | 14.3 | 11.9 | 10.2 | 15.2 | 9.5 | 10.3 | 20.9 | 15.2 | 14.5 | 15 | 15 | 15 |
| sum | 5.9 | 4.3 | 5.5 | 6.6 | 4.8 | 4.7 | 8.9 | 6.4 | 7.2 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 14.8 | 8.8 | 5.6 | 14 | 7.8 | 7.2 | 20.4 | 11.8 | 9.1 | 15 | 15 | 15 |
| y4 (1+) | 11 | 6.6 | 4.1 | 11.3 | 7.6 | 4.8 | 15.8 | 10.1 | 6.3 | 15 | 15 | 15 |
| y5 (1+) | 10.7 | 8.3 | 3.1 | 11.5 | 9.9 | 4.7 | 15.7 | 12.9 | 5.6 | 15 | 15 | 15 |
| y6 (1+) | 6.6 | 6.1 | 6.5 | 6.7 | 8.3 | 5.4 | 9.4 | 10.3 | 8.5 | 15 | 15 | 15 |
| y7 (1+) | 7.5 | 3.9 | 4.2 | 9.3 | 4.6 | 4.7 | 11.9 | 6 | 6.3 | 15 | 15 | 15 |
| y8 (1+) | 10.4 | 4.8 | 4.6 | 9 | 4.2 | 5.2 | 13.8 | 6.4 | 6.9 | 15 | 15 | 15 |
| y9 (1+) | 4.5 | 6.4 | 4.9 | 5.4 | 5.6 | 5.3 | 7 | 8.5 | 7.2 | 15 | 15 | 15 |
| y10 (1+) | 10.8 | 8.2 | 3.9 | 12.6 | 8.4 | 6.1 | 16.6 | 11.7 | 7.2 | 15 | 15 | 15 |
| b3 (1+) | 12.7 | 7.8 | 7 | 13 | 6.9 | 6.9 | 18.2 | 10.4 | 9.8 | 15 | 15 | 15 |
| sum | 3.7 | 1.5 | 1.9 | 3.7 | 1.9 | 2.2 | 5.2 | 2.4 | 2.9 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 21.3 | 13.7 | 13.7 | 28 | 13.8 | 13.9 | 35.2 | 19.4 | 19.5 | 15 | 15 | 15 |
| y4 (1+) | 28.6 | 9.3 | 5.6 | 28.2 | 10 | 7.7 | 40.2 | 13.7 | 9.5 | 15 | 15 | 15 |
| y5 (1+) | 19 | 11.9 | 10.8 | 22.1 | 11.8 | 12.9 | 29.1 | 16.8 | 16.8 | 15 | 15 | 15 |
| y6 (1+) | 12.6 | 4.6 | 5.8 | 15.6 | 5.6 | 7.2 | 20.1 | 7.2 | 9.2 | 15 | 15 | 15 |
| y7 (1+) | 11.5 | 8.2 | 9.1 | 15.6 | 7.3 | 8.5 | 19.4 | 11 | 12.5 | 15 | 15 | 15 |
| y8 (1+) | 17.1 | 5.3 | 9.8 | 17.5 | 6.5 | 7.5 | 24.5 | 8.4 | 12.3 | 15 | 15 | 15 |
| y9 (1+) | 21.1 | 9.5 | 5.3 | 24.6 | 9.6 | 8 | 32.4 | 13.5 | 9.6 | 15 | 15 | 15 |
| sum | 8.6 | 2.2 | 3.6 | 7.2 | 3.5 | 4.8 | 11.2 | 4.1 | 6 | 15 | 15 | 15 |
Data source: Panorama
Data source: Panorama
Data source: Panorama
Data source: Panorama
Retrieving Data
Data source: Panorama
| Average intra-assay CV (within day CV) |
Average inter-assay CV (between day CV) |
Total CV |
n= | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fragment ion / Transition | Low | Med | High | Low | Med | High | Low | Med | High | Low | Med | High |
| y3 (1+) | 8.6 | 9 | 14.1 | 9.7 | 9.4 | 14.1 | 13 | 13 | 19.9 | 15 | 15 | 15 |
| y4 (1+) | 9.3 | 9.5 | 4.9 | 13 | 9.7 | 7.5 | 16 | 13.6 | 9 | 15 | 15 | 15 |
| y5 (1+) | 12.5 | 8.4 | 7.6 | 13.5 | 8.9 | 7.6 | 18.4 | 12.2 | 10.7 | 15 | 15 | 15 |
| y6 (1+) | 4.3 | 2.9 | 4.6 | 7.1 | 3.8 | 3 | 8.3 | 4.8 | 5.5 | 15 | 15 | 15 |
| y7 (1+) | 8.1 | 9.7 | 6.2 | 9 | 8.6 | 4.4 | 12.1 | 13 | 7.6 | 15 | 15 | 15 |
| y8 (1+) | 15.1 | 10.5 | 5.3 | 15.4 | 11.7 | 6.2 | 21.6 | 15.7 | 8.2 | 15 | 15 | 15 |
| y9 (1+) | 12.2 | 3.3 | 4.4 | 13.8 | 6.9 | 5 | 18.4 | 7.6 | 6.7 | 15 | 15 | 15 |
| b9 (1+) | 14.9 | 8.2 | 6.7 | 17.4 | 9.3 | 7.5 | 22.9 | 12.4 | 10.1 | 15 | 15 | 15 |
| b8 (1+) | 14.9 | 7.9 | 6.4 | 18.7 | 7.4 | 7.3 | 23.9 | 10.8 | 9.7 | 15 | 15 | 15 |
| b7 (1+) | 11.6 | 4.8 | 5.2 | 12.9 | 3.7 | 5.3 | 17.3 | 6.1 | 7.4 | 15 | 15 | 15 |
| b6 (1+) | 11.2 | 5.5 | 3.8 | 8.3 | 5.5 | 3.6 | 13.9 | 7.8 | 5.2 | 15 | 15 | 15 |
| b4 (1+) | 8 | 6.5 | 7.9 | 14.4 | 7.4 | 7.8 | 16.5 | 9.8 | 11.1 | 15 | 15 | 15 |
| sum | 3.4 | 1.3 | 2 | 3.9 | 1.8 | 1.9 | 5.2 | 2.2 | 2.8 | 15 | 15 | 15 |
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