iBet uBet
web content aggregator. Adding the entire web to your favor.
Link to original content:
https://api.openalex.org/works/doi:10.48550/ARXIV.2405.00070
{"id":"https://openalex.org/W4396601020","doi":"https://doi.org/10.48550/arxiv.2405.00070","title":"Bayesian-Guided Generation of Synthetic Microbiomes with Minimized\n Pathogenicity","display_name":"Bayesian-Guided Generation of Synthetic Microbiomes with Minimized\n Pathogenicity","publication_year":2024,"publication_date":"2024-04-29","ids":{"openalex":"https://openalex.org/W4396601020","doi":"https://doi.org/10.48550/arxiv.2405.00070"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2405.00070","pdf_url":"https://arxiv.org/pdf/2405.00070","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":["Cornell University"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false},"type":"preprint","type_crossref":"posted-content","indexed_in":["arxiv"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2405.00070","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022338382","display_name":"Nisha Pillai","orcid":"https://orcid.org/0000-0002-2275-6998"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pillai, Nisha","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060469989","display_name":"Bindu Nanduri","orcid":"https://orcid.org/0000-0002-9996-2976"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nanduri, Bindu","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030287450","display_name":"Michael J. Rothrock","orcid":"https://orcid.org/0000-0003-4248-6478"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rothrock Jr., Michael J","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082832007","display_name":"Zhiqian Chen","orcid":"https://orcid.org/0000-0003-4112-9647"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chen, Zhiqian","raw_affiliation_strings":[],"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5101812991","display_name":"Mahalingam Ramkumar","orcid":"https://orcid.org/0000-0003-3183-0165"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramkumar, Mahalingam","raw_affiliation_strings":[],"affiliations":[]}],"institution_assertions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":0,"max":85},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T13937","display_name":"Challenges and Innovations in Bioinformatics Education","score":0.5385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13937","display_name":"Challenges and Innovations in Bioinformatics Education","score":0.5385,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational Biology","score":0.538862}],"concepts":[{"id":"https://openalex.org/C64502627","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogenicity","level":2,"score":0.7479404},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.7410962},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5623624},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.53250754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4925135},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3963002},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.38353533},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25010258},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.21492112}],"mesh":[],"locations_count":1,"locations":[{"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2405.00070","pdf_url":"https://arxiv.org/pdf/2405.00070","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":["Cornell University"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://arxiv.org/abs/2405.00070","pdf_url":"https://arxiv.org/pdf/2405.00070","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":["Cornell University"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false},"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4393043634","https://openalex.org/W4390658901","https://openalex.org/W4388834263","https://openalex.org/W4206185765","https://openalex.org/W3121185202","https://openalex.org/W3088497233","https://openalex.org/W3035180550","https://openalex.org/W2900546243","https://openalex.org/W2604155846","https://openalex.org/W1983943311"],"abstract_inverted_index":{"Synthetic":[0],"microbiomes":[1,158],"offer":[2],"new":[3],"possibilities":[4],"for":[5,70,145],"modulating":[6],"microbiota,":[7],"to":[8,23,34,67,73,111],"address":[9],"the":[10,28,152],"barriers":[11],"in":[12],"multidtug":[13],"resistance":[14],"(MDR)":[15],"research.":[16],"We":[17],"present":[18],"a":[19,46],"Bayesian":[20,62,143],"optimization":[21,63],"approach":[22],"enable":[24],"efficient":[25,146],"searching":[26],"over":[27],"space":[29,49,55,140],"of":[30,38,58,76,100,122,154],"synthetic":[31,59,106,126,157],"microbiome":[32,60,127],"variants":[33,69],"identify":[35],"candidates":[36,128],"predictive":[37],"reduced":[39],"MDR.":[40],"Microbiome":[41],"datasets":[42],"were":[43,89,108],"encoded":[44],"into":[45],"low-dimensional":[47],"latent":[48,139],"using":[50],"autoencoders.":[51],"Sampling":[52],"from":[53],"this":[54,149],"allowed":[56],"generation":[57],"signatures.":[61],"was":[64],"then":[65],"implemented":[66],"select":[68],"biological":[71],"screening":[72],"maximize":[74],"identification":[75],"designs":[77],"with":[78,129,159],"restricted":[79],"MDR":[80,113,161],"pathogens":[81],"based":[82],"on":[83,103],"minimal":[84],"samples.":[85],"Four":[86],"acquisition":[87],"functions":[88],"evaluated:":[90],"expected":[91],"improvement,":[92,116],"upper":[93,117],"confidence":[94,118],"bound,":[95,119],"Thompson":[96,134],"sampling,":[97],"and":[98,120,142],"probability":[99,121],"improvement.":[101],"Based":[102],"each":[104],"strategy,":[105],"samples":[107],"prioritized":[109],"according":[110],"their":[112],"detection.":[114],"Expected":[115],"improvement":[123],"consistently":[124],"produced":[125],"significantly":[130],"fewer":[131],"searches":[132],"than":[133],"sampling.":[135],"By":[136],"combining":[137],"deep":[138],"mapping":[141],"learning":[144],"guided":[147],"screening,":[148],"study":[150],"demonstrated":[151],"feasibility":[153],"creating":[155],"bespoke":[156],"customized":[160],"profiles.":[162]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W4396601020","counts_by_year":[],"updated_date":"2024-11-28T14:19:36.408781","created_date":"2024-05-03"}
