{"id":"https://openalex.org/W3214716029","doi":"https://doi.org/10.3233/shti210833","title":"Challenges and Experiences Extending the cBioPortal for Cancer Genomics to a Molecular Tumor Board Platform","display_name":"Challenges and Experiences Extending the cBioPortal for Cancer Genomics to a Molecular Tumor Board Platform","publication_year":2021,"publication_date":"2021-11-18","ids":{"openalex":"https://openalex.org/W3214716029","doi":"https://doi.org/10.3233/shti210833","mag":"3214716029","pmid":"https://pubmed.ncbi.nlm.nih.gov/34795098"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210833","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210833","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210833","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077283446","display_name":"Niklas Reimer","orcid":"https://orcid.org/0000-0002-0491-3929"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Niklas Reimer","raw_affiliation_strings":["Group for Medical Systems Biology, L\u00fcbeck Institute of Experimental Dermatology, Universit\u00e4t zu L\u00fcbeck, Germany"],"affiliations":[{"raw_affiliation_string":"Group for Medical Systems Biology, L\u00fcbeck Institute of Experimental Dermatology, Universit\u00e4t zu L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025720706","display_name":"Philipp Unberath","orcid":"https://orcid.org/0000-0002-1269-9360"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Philipp Unberath","raw_affiliation_strings":["Group for Medical Systems Biology, L\u00fcbeck Institute of Experimental Dermatology, Universit\u00e4t zu L\u00fcbeck, Germany"],"affiliations":[{"raw_affiliation_string":"Group for Medical Systems Biology, L\u00fcbeck Institute of Experimental Dermatology, Universit\u00e4t zu L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086749090","display_name":"Hauke Busch","orcid":"https://orcid.org/0000-0003-4763-4521"},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hauke Busch","raw_affiliation_strings":["Group for Medical Systems Biology, L\u00fcbeck Institute of Experimental Dermatology, Universit\u00e4t zu L\u00fcbeck, Germany"],"affiliations":[{"raw_affiliation_string":"Group for Medical Systems Biology, L\u00fcbeck Institute of Experimental Dermatology, Universit\u00e4t zu L\u00fcbeck, Germany","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040080869","display_name":"Melanie B\u00f6rries","orcid":null},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Melanie B\u00f6rries","raw_affiliation_strings":["German Cancer Consortium (DKTK) Partner Site Freiburg and Cancer Research Center (DKFZ), Heidelberg, Germany","Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine and Medical Center \u2013 University of Freiburg, Freiburg, Germany","Medical Center -University of Freiburg, Freiburg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine and Medical Center \u2013 University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"German Cancer Consortium (DKTK) Partner Site Freiburg and Cancer Research Center (DKFZ), Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Medical Center -University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081","https://openalex.org/I2801240073"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086119203","display_name":"Patrick Metzger","orcid":"https://orcid.org/0000-0002-2451-1943"},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]},{"id":"https://openalex.org/I2801240073","display_name":"University Medical Center Freiburg","ror":"https://ror.org/03vzbgh69","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2801240073"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick Metzger","raw_affiliation_strings":["Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine and Medical Center \u2013 University of Freiburg, Freiburg, Germany","Medical Center -University of Freiburg, Freiburg, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine and Medical Center \u2013 University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I161046081"]},{"raw_affiliation_string":"Medical Center -University of Freiburg, Freiburg, Germany","institution_ids":["https://openalex.org/I2801240073","https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039591070","display_name":"Arsenij Ustjanzew","orcid":"https://orcid.org/0000-0002-1014-4521"},"institutions":[],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arsenij Ustjanzew","raw_affiliation_strings":["Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Johannes Gutenberg-University School of Medicine, Mainz, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Johannes Gutenberg-University School of Medicine, Mainz, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069027283","display_name":"Christopher Renner","orcid":"https://orcid.org/0009-0001-7537-3931"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christopher Renner","raw_affiliation_strings":["Department of Medical Informatics, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052931994","display_name":"Hans\u2010Ulrich Prokosch","orcid":"https://orcid.org/0000-0001-6200-753X"},"institutions":[{"id":"https://openalex.org/I181369854","display_name":"Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg","ror":"https://ror.org/00f7hpc57","country_code":"DE","type":"education","lineage":["https://openalex.org/I181369854"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Ulrich Prokosch","raw_affiliation_strings":["Department of Medical Informatics, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Medical Informatics, Friedrich-Alexander-Universit\u00e4t Erlangen-N\u00fcrnberg, Erlangen, Germany","institution_ids":["https://openalex.org/I181369854"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080416734","display_name":"Jan Christoph","orcid":"https://orcid.org/0000-0003-4369-3591"},"institutions":[{"id":"https://openalex.org/I68956291","display_name":"Martin Luther University Halle-Wittenberg","ror":"https://ror.org/05gqaka33","country_code":"DE","type":"education","lineage":["https://openalex.org/I68956291"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jan Christoph","raw_affiliation_strings":["Junior Research Group (Bio-)Medical Data Science, Martin-Luther-University Halle-Wittenberg, Faculty of Medicine, Halle, Germany"],"affiliations":[{"raw_affiliation_string":"Junior Research Group (Bio-)Medical Data Science, Martin-Luther-University Halle-Wittenberg, Faculty of Medicine, Halle, Germany","institution_ids":["https://openalex.org/I68956291","https://openalex.org/I68956291"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5077283446"],"corresponding_institution_ids":["https://openalex.org/I9341345"],"apc_list":null,"apc_paid":null,"fwci":1.003,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":13,"citation_normalized_percentile":{"value":0.646993,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":91},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9944,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.9944,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11986","display_name":"Scientific Computing and Data Management","score":0.9652,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9597,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"Cancer Genomics","score":0.484891}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.8022586},{"id":"https://openalex.org/C105339364","wikidata":"https://www.wikidata.org/wiki/Q2297740","display_name":"Software deployment","level":2,"score":0.7035566},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.4452087},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.41595238},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.3895647},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.36137623},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34703016},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33945546},{"id":"https://openalex.org/C115903868","wikidata":"https://www.wikidata.org/wiki/Q80993","display_name":"Software engineering","level":1,"score":0.23000899},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18047127},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.15451214},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.13676369},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.11143085},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08503288},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210833","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210833","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34795098","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.3233/shti210833","pdf_url":"https://ebooks.iospress.nl/pdf/doi/10.3233/SHTI210833","source":{"id":"https://openalex.org/S4210179765","display_name":"Studies in health technology and informatics","issn_l":"0926-9630","issn":["0926-9630","1879-8365"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[],"grants":[],"datasets":[],"versions":[],"referenced_works_count":10,"referenced_works":["https://openalex.org/W2114843025","https://openalex.org/W2171756499","https://openalex.org/W2296335794","https://openalex.org/W2883427794","https://openalex.org/W2887809138","https://openalex.org/W2894794416","https://openalex.org/W2942102370","https://openalex.org/W3005435850","https://openalex.org/W3135065167","https://openalex.org/W3164144477"],"related_works":["https://openalex.org/W632915154","https://openalex.org/W620798607","https://openalex.org/W4378874356","https://openalex.org/W4229499248","https://openalex.org/W3089997100","https://openalex.org/W2987774938","https://openalex.org/W2770234245","https://openalex.org/W2566006169","https://openalex.org/W2369811061","https://openalex.org/W1607147593"],"abstract_inverted_index":{"In":[0,47],"Molecular":[1],"Tumor":[2],"Boards":[3],"(MTBs),":[4],"therapy":[5],"recommendations":[6],"for":[7],"cancer":[8],"patients":[9],"are":[10],"discussed.":[11],"To":[12],"aid":[13],"decision-making":[14],"based":[15,27,67],"on":[16,28,68],"the":[17,21,40,52],"patient\u2019s":[18],"molecular":[19],"profile,":[20],"research":[22],"platform":[23,66],"cBioPortal":[24,43,69],"was":[25,36],"extended":[26],"users\u2019":[29],"requirements.":[30],"Additionally,":[31],"a":[32,76],"comprehensive":[33],"dockerized":[34],"workflow":[35],"developed":[37],"to":[38,73],"support":[39],"deployment":[41],"of":[42,56,60,75],"and":[44,54,62,70],"connected":[45],"services.":[46],"this":[48],"work,":[49],"we":[50],"present":[51],"challenges":[53],"experiences":[55],"nearly":[57],"two":[58],"years":[59],"implementing":[61],"deploying":[63],"an":[64],"MTB":[65],"compare":[71],"those":[72],"findings":[74],"previous":[77],"study.":[78]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W3214716029","counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":3}],"updated_date":"2024-12-05T18:07:45.929996","created_date":"2021-11-22"}