{"id":"https://openalex.org/W2965390994","doi":"https://doi.org/10.1371/journal.pcbi.1007246","title":"Every which way? On predicting tumor evolution using cancer progression models","display_name":"Every which way? On predicting tumor evolution using cancer progression models","publication_year":2019,"publication_date":"2019-08-02","ids":{"openalex":"https://openalex.org/W2965390994","doi":"https://doi.org/10.1371/journal.pcbi.1007246","mag":"2965390994","pmid":"https://pubmed.ncbi.nlm.nih.gov/31374072","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6693785"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007246","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007246&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007246&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080620893","display_name":"Ram\u00f3n D\u0131\u0301az-Uriarte","orcid":"https://orcid.org/0000-0002-6637-9039"},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Autonomous University of Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]},{"id":"https://openalex.org/I4210091816","display_name":"Instituto de Investigaciones Biom\u00e9dicas Sols-Morreale","ror":"https://ror.org/00ha1f767","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Ramon Diaz-Uriarte","raw_affiliation_strings":["Department of Biochemistry, Universidad Aut\u00f3noma de Madrid, Madrid, Spain","Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols\u201d (UAM-CSIC), Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols\u201d (UAM-CSIC), Madrid, Spain","institution_ids":["https://openalex.org/I63634437","https://openalex.org/I4210091816"]},{"raw_affiliation_string":"Department of Biochemistry, Universidad Aut\u00f3noma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011746355","display_name":"Claudia Vasallo","orcid":"https://orcid.org/0000-0002-0043-0882"},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Autonomous University of Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]},{"id":"https://openalex.org/I4210091816","display_name":"Instituto de Investigaciones Biom\u00e9dicas Sols-Morreale","ror":"https://ror.org/00ha1f767","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210091816","https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Claudia Vasallo","raw_affiliation_strings":["Department of Biochemistry, Universidad Aut\u00f3noma de Madrid, Madrid, Spain","Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols\u201d (UAM-CSIC), Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Universidad Aut\u00f3noma de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Instituto de Investigaciones Biom\u00e9dicas \u201cAlberto Sols\u201d (UAM-CSIC), Madrid, Spain","institution_ids":["https://openalex.org/I4210091816","https://openalex.org/I63634437"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080620893"],"corresponding_institution_ids":["https://openalex.org/I63634437","https://openalex.org/I4210091816"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655,"provenance":"doaj"},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655,"provenance":"doaj"},"fwci":1.96,"has_fulltext":true,"fulltext_origin":"pdf","cited_by_count":31,"citation_normalized_percentile":{"value":0.999909,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":95},"biblio":{"volume":"15","issue":"8","first_page":"e1007246","last_page":"e1007246"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Genomic Landscape of Cancer and Mutational Signatures","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Genomic Landscape of Cancer and Mutational Signatures","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolutionary Dynamics of Genetic Adaptation and Mutation","score":0.9995,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genomic Studies and Association Analyses","score":0.9943,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fitness-landscape","display_name":"Fitness landscape","score":0.6302563},{"id":"https://openalex.org/keywords/tumor-evolution","display_name":"Tumor Evolution","score":0.578311},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"Tumor progression","score":0.5530143},{"id":"https://openalex.org/keywords/cancer-genomics","display_name":"Cancer Genomics","score":0.531488},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.50713444}],"concepts":[{"id":"https://openalex.org/C91852762","wikidata":"https://www.wikidata.org/wiki/Q3307742","display_name":"Fitness landscape","level":3,"score":0.6302563},{"id":"https://openalex.org/C129848803","wikidata":"https://www.wikidata.org/wiki/Q2564360","display_name":"Sample size determination","level":2,"score":0.61660224},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.5530143},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.53007686},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.50713444},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.470351},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.44114792},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4260485},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.35556138},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.32809767},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.29535854},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24711594},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1864874},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.09155536},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009385","descriptor_name":"Neoplastic Processes","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007246","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007246&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://doaj.org/article/d9afa8a9e82d44c59fbe2d29341dd90d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},{"is_oa":true,"landing_page_url":"https://europepmc.org/articles/pmc6693785","pdf_url":"https://europepmc.org/articles/pmc6693785?pdf=render","source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":["European Bioinformatics Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://hdl.handle.net/10261/206536","pdf_url":"https://digital.csic.es/bitstream/10261/206536/1/Every_Which_Way_Diaz_Uriarte_Art2019.pdf","source":{"id":"https://openalex.org/S4306401639","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":["Consejo Superior de Investigaciones Cient\u00edficas"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://hdl.handle.net/10486/690558","pdf_url":"https://repositorio.uam.es/bitstream/10486/690558/1/every_diaz_PCB_2019.pdf","source":{"id":"https://openalex.org/S4306400964","display_name":"Biblos-e Archivo (Universidad Aut\u00f3noma de Madrid)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I63634437","host_organization_name":"Autonomous University of Madrid","host_organization_lineage":["https://openalex.org/I63634437"],"host_organization_lineage_names":["Autonomous University of Madrid"],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693785","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":true,"landing_page_url":"https://doi.org/10.1101/371039","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31374072","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007246","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007246&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310316756","host_organization_name":"International Society for Computational Biology","host_organization_lineage":["https://openalex.org/P4310316756"],"host_organization_lineage_names":["International Society for Computational Biology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"score":0.49,"id":"https://metadata.un.org/sdg/1","display_name":"No poverty"}],"grants":[{"funder":"https://openalex.org/F4320325116","funder_display_name":"Consejer\u00eda de Educaci\u00f3n, Juventud y Deporte, Comunidad de Madrid","award_id":"PEJD-2016-BMD-2116"},{"funder":"https://openalex.org/F4320326262","funder_display_name":"Ministerio de Asuntos Econ\u00f3micos y Transformaci\u00f3n Digital, Gobierno de Espa\u00f1a","award_id":"BFU2015-67302-R"}],"datasets":[],"versions":[],"referenced_works_count":85,"referenced_works":["https://openalex.org/W1479703621","https://openalex.org/W1528905581","https://openalex.org/W1598410563","https://openalex.org/W1773422510","https://openalex.org/W1964154017","https://openalex.org/W1970185413","https://openalex.org/W1974227993","https://openalex.org/W1975407466","https://openalex.org/W1975675040","https://openalex.org/W1983708207","https://openalex.org/W1998643818","https://openalex.org/W2011153754","https://openalex.org/W2012611161","https://openalex.org/W2012977051","https://openalex.org/W2015631955","https://openalex.org/W2025183726","https://openalex.org/W2036821522","https://openalex.org/W2040490772","https://openalex.org/W2040827479","https://openalex.org/W2042536531","https://openalex.org/W2044702943","https://openalex.org/W2050086663","https://openalex.org/W2059437408","https://openalex.org/W2061285646","https://openalex.org/W2069086572","https://openalex.org/W2073294762","https://openalex.org/W2077098920","https://openalex.org/W2096283457","https://openalex.org/W2098608887","https://openalex.org/W2101354849","https://openalex.org/W2109816625","https://openalex.org/W2109860416","https://openalex.org/W2122882636","https://openalex.org/W2123696077","https://openalex.org/W2126643167","https://openalex.org/W2132691934","https://openalex.org/W2136155563","https://openalex.org/W2137297899","https://openalex.org/W2137549067","https://openalex.org/W2138122783","https://openalex.org/W2138155367","https://openalex.org/W2146950091","https://openalex.org/W2150073600","https://openalex.org/W2153938747","https://openalex.org/W2159267296","https://openalex.org/W2163798887","https://openalex.org/W2165327448","https://openalex.org/W2167278498","https://openalex.org/W2174686320","https://openalex.org/W2209688796","https://openalex.org/W2233432342","https://openalex.org/W2233833799","https://openalex.org/W2253465175","https://openalex.org/W2259572413","https://openalex.org/W2262414037","https://openalex.org/W2270380494","https://openalex.org/W2402811940","https://openalex.org/W2513118531","https://openalex.org/W2560367415","https://openalex.org/W2562809264","https://openalex.org/W2586544027","https://openalex.org/W260994251","https://openalex.org/W2612496317","https://openalex.org/W2654931540","https://openalex.org/W2704159227","https://openalex.org/W2740141059","https://openalex.org/W2767078712","https://openalex.org/W2786358356","https://openalex.org/W2796625107","https://openalex.org/W2888094747","https://openalex.org/W2898806520","https://openalex.org/W2900081903","https://openalex.org/W2949890743","https://openalex.org/W2951391875","https://openalex.org/W2953058007","https://openalex.org/W2961229668","https://openalex.org/W3098077827","https://openalex.org/W3101634756","https://openalex.org/W3122312322","https://openalex.org/W4210370111","https://openalex.org/W4210953474","https://openalex.org/W4238448376","https://openalex.org/W4243563270","https://openalex.org/W4249444071","https://openalex.org/W4301861531"],"related_works":["https://openalex.org/W4388813866","https://openalex.org/W4293088233","https://openalex.org/W2999104021","https://openalex.org/W2850804095","https://openalex.org/W2800688113","https://openalex.org/W2774950576","https://openalex.org/W2162280767","https://openalex.org/W2057598446","https://openalex.org/W1570799877","https://openalex.org/W1481656249"],"abstract_inverted_index":{"Successful":[0],"prediction":[1],"of":[2,6,30,32,41,49,64,66,99,101,154,157,197,208,214,217,219,231,253,255],"the":[3,28,39,47,61,114,161,166,172,176,192,209,215,229,264,273],"likely":[4],"paths":[5,40,65,100,218,254],"tumor":[7,42,67,102,220,256],"progression":[8,18,68,103,221,246,257],"is":[9,91,111,132,150,178,260],"valuable":[10,241],"for":[11,187,206,243,266,272],"diagnostic,":[12],"prognostic,":[13],"and":[14,35,69,96,134,175,225,262],"treatment":[15],"purposes.":[16],"Cancer":[17],"models":[19],"(CPMs)":[20],"use":[21],"cross-sectional":[22],"samples":[23],"to":[24,52,59,70,170,191],"identify":[25],"restrictions":[26],"in":[27,278],"order":[29],"accumulation":[31],"driver":[33],"mutations":[34],"thus":[36],"CPMs":[37,51,183,238,259],"encode":[38],"progression.":[43],"Here":[44],"we":[45,76],"analyze":[46],"performance":[48,110,131],"four":[50,167],"examine":[53],"whether":[54],"they":[55],"can":[56,270],"be":[57,185,240],"used":[58],"predict":[60],"true":[62,95,173,193],"distribution":[63],"estimate":[71],"evolutionary":[72,158,194,204],"unpredictability.":[73,195],"Employing":[74],"simulations":[75],"show":[77],"that":[78,237,269],"if":[79],"fitness":[80,88,123,129,276],"landscapes":[81,124,277],"are":[82,107,148,222],"single":[83,87],"peaked":[84],"(have":[85],"a":[86,151],"maximum)":[89],"there":[90],"good":[92],"agreement":[93],"between":[94],"predicted":[97],"distributions":[98],"when":[104],"sample":[105,119,139],"sizes":[106],"large,":[108],"but":[109,247],"poor":[112,133],"with":[113,127,138,228],"currently":[115],"common":[116],"much":[117],"smaller":[118],"sizes.":[120],"Under":[121],"multi-peaked":[122,275],"(i.e.,":[125],"those":[126],"multiple":[128],"maxima),":[130],"improves":[135],"only":[136],"slightly":[137],"size.":[140],"In":[141],"all":[142],"cases,":[143],"detection":[144,181],"regime":[145],"(when":[146],"tumors":[147],"sampled)":[149],"key":[152],"determinant":[153],"performance.":[155],"Estimates":[156],"unpredictability":[159,174,205],"from":[160,258],"best":[162],"performing":[163],"CPM,":[164],"among":[165],"examined,":[168],"tend":[169],"overestimate":[171],"bias":[177],"affected":[179],"by":[180],"regime;":[182],"could":[184,239],"useful":[186,251],"estimating":[188],"upper":[189],"bounds":[190],"Analysis":[196],"twenty-two":[198],"cancer":[199,245],"data":[200,210],"sets":[201],"shows":[202],"low":[203],"several":[207],"sets.":[211],"But":[212],"most":[213],"predictions":[216,252],"very":[223],"unreliable,":[224],"unreliability":[226],"increases":[227],"number":[230],"features":[232],"analyzed.":[233],"Our":[234],"results":[235],"indicate":[236],"tools":[242],"predicting":[244],"that,":[248],"currently,":[249],"obtaining":[250],"dubious,":[261],"emphasize":[263],"need":[265],"methodological":[267],"work":[268],"account":[271],"probably":[274],"cancer.":[279]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2965390994","counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2024-11-13T11:37:30.443912","created_date":"2019-08-13"}
