{"id":"https://openalex.org/W2507445921","doi":"https://doi.org/10.1093/bib/bbw081","title":"Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes","display_name":"Comprehensive characterization of tissue-specific circular RNAs in the human and mouse genomes","publication_year":2016,"publication_date":"2016-08-20","ids":{"openalex":"https://openalex.org/W2507445921","doi":"https://doi.org/10.1093/bib/bbw081","mag":"2507445921","pmid":"https://pubmed.ncbi.nlm.nih.gov/27543790"},"language":"en","primary_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbw081","pdf_url":"https://academic.oup.com/bib/article-pdf/18/6/984/25603495/bbw081.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},"type":"article","type_crossref":"journal-article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/18/6/984/25603495/bbw081.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046582691","display_name":"Siyu Xia","orcid":"https://orcid.org/0000-0002-4241-4944"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siyu Xia","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102940907","display_name":"Jing Feng","orcid":"https://orcid.org/0000-0002-7425-2994"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Feng","raw_affiliation_strings":["International School of Software, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"International School of Software, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109335190","display_name":"Li-Jun Lei","orcid":null},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lijun Lei","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101582684","display_name":"Jun Hu","orcid":"https://orcid.org/0000-0001-9107-8118"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Hu","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101941621","display_name":"Linjian Xia","orcid":"https://orcid.org/0000-0003-1523-2958"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linjian Xia","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111964102","display_name":"Jun Wang","orcid":"https://orcid.org/0009-0008-8475-2934"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Wang","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100685652","display_name":"Yu Xiang","orcid":"https://orcid.org/0000-0001-9199-3383"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu Xiang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938","https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031778950","display_name":"Lingjun Liu","orcid":"https://orcid.org/0000-0002-2892-7831"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingjun Liu","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101731427","display_name":"Shan Zhong","orcid":"https://orcid.org/0009-0007-0802-0902"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Zhong","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048715916","display_name":"Leng Han","orcid":"https://orcid.org/0000-0002-7380-2640"},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leng Han","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938","https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034357519","display_name":"Chunjiang He","orcid":"https://orcid.org/0000-0002-4868-331X"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunjiang He","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan, China"],"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, China","institution_ids":["https://openalex.org/I37461747"]}]}],"institution_assertions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048715916","https://openalex.org/A5034357519"],"corresponding_institution_ids":["https://openalex.org/I919571938","https://openalex.org/I37461747"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011,"provenance":"doaj"},"apc_paid":null,"fwci":9.453,"has_fulltext":true,"fulltext_origin":"ngrams","cited_by_count":329,"citation_normalized_percentile":{"value":0.846214,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":null,"issue":null,"first_page":"bbw081","last_page":"bbw081"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Biogenesis and Functions of Circular RNAs","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Biogenesis and Functions of Circular RNAs","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA Regulation in Cancer and Development","score":0.993,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Role of Long Noncoding RNAs in Cancer and Development","score":0.9886,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circular-rna","display_name":"Circular RNA","score":0.79541457},{"id":"https://openalex.org/keywords/circular-rnas","display_name":"Circular RNAs","score":0.591704}],"concepts":[{"id":"https://openalex.org/C2775893923","wikidata":"https://www.wikidata.org/wiki/Q17113455","display_name":"Circular RNA","level":4,"score":0.79541457},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7518437},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.6169721},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.58241284},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5724588},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5449305},{"id":"https://openalex.org/C197077220","wikidata":"https://www.wikidata.org/wiki/Q720988","display_name":"Human genome","level":4,"score":0.52918714},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.43745244},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.41706094},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36371797}],"mesh":[{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016678","descriptor_name":"Genome","qualifier_ui":"","qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"","qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"","qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbw081","pdf_url":"https://academic.oup.com/bib/article-pdf/18/6/984/25603495/bbw081.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},{"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27543790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":["National Institutes of Health"],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":{"is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbw081","pdf_url":"https://academic.oup.com/bib/article-pdf/18/6/984/25603495/bbw081.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311647","https://openalex.org/P4310311648"],"host_organization_lineage_names":["University of Oxford","Oxford University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true},"sustainable_development_goals":[{"display_name":"Life on land","id":"https://metadata.un.org/sdg/15","score":0.7}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":47,"referenced_works":["https://openalex.org/W1032731786","https://openalex.org/W1566841623","https://openalex.org/W1770991729","https://openalex.org/W1866220599","https://openalex.org/W1966557314","https://openalex.org/W1967791012","https://openalex.org/W1981726010","https://openalex.org/W1991082489","https://openalex.org/W2019230794","https://openalex.org/W2023139734","https://openalex.org/W2034587103","https://openalex.org/W2051615060","https://openalex.org/W2054891772","https://openalex.org/W2055493067","https://openalex.org/W2058835062","https://openalex.org/W2060940710","https://openalex.org/W2064165694","https://openalex.org/W2086055453","https://openalex.org/W2088128227","https://openalex.org/W2100155969","https://openalex.org/W2107903949","https://openalex.org/W2110884132","https://openalex.org/W2115662330","https://openalex.org/W2117013291","https://openalex.org/W2117977572","https://openalex.org/W2118675686","https://openalex.org/W2122683221","https://openalex.org/W2124799197","https://openalex.org/W2126938291","https://openalex.org/W2134629862","https://openalex.org/W2141831115","https://openalex.org/W2147625377","https://openalex.org/W2152719653","https://openalex.org/W2162674813","https://openalex.org/W2168783124","https://openalex.org/W2174483798","https://openalex.org/W2177654732","https://openalex.org/W2194134194","https://openalex.org/W2210577735","https://openalex.org/W2247766769","https://openalex.org/W2266356262","https://openalex.org/W2290820108","https://openalex.org/W2316171452","https://openalex.org/W2325848215","https://openalex.org/W2326363926","https://openalex.org/W2398883032","https://openalex.org/W2473991067"],"related_works":["https://openalex.org/W4303983510","https://openalex.org/W3194395666","https://openalex.org/W3046695129","https://openalex.org/W3030236128","https://openalex.org/W2993030379","https://openalex.org/W2906670751","https://openalex.org/W2597420727","https://openalex.org/W2115295975","https://openalex.org/W2034458000","https://openalex.org/W2024248021"],"abstract_inverted_index":{"Circular":[0],"RNA":[1,7,11,130],"(circRNA)":[2],"is":[3,24,169],"a":[4],"group":[5],"of":[6,28,45,75,83,100,109,123,164,174],"family":[8],"generated":[9,113],"by":[10,85],"circularization,":[12],"which":[13,133,181],"was":[14],"discovered":[15],"ubiquitously":[16],"across":[17],"different":[18],"species":[19],"and":[20,47,63,66,98,104,129,146,179,190],"tissues.":[21],"However,":[22],"there":[23],"no":[25],"global":[26],"view":[27,173],"tissue":[29],"specificity":[30],"for":[31],"circRNAs":[32,59,84,103,111,176],"to":[33,41,136,160],"date.":[34],"Here":[35],"we":[36,126,150],"performed":[37],"the":[38,43,61,69,72,81,95,107,120,162,170],"comprehensive":[39,172],"analysis":[40],"characterize":[42],"features":[44,163],"human":[46,62,178],"mouse":[48,64],"tissue-specific":[49],"(TS)":[50],"circRNAs.":[51,77,138,166],"We":[52,78,92],"identified":[53,127],"in":[54,60,144,177,187],"total":[55],"302":[56],"853":[57],"TS":[58,76,102,110,124,137,165,175],"genome,":[65],"showed":[67,105],"that":[68,106],"brain":[70],"has":[71],"highest":[73],"abundance":[74],"further":[79,118],"confirmed":[80],"existence":[82],"reverse":[86],"transcription":[87],"polymerase":[88],"chain":[89],"reaction":[90],"(RT-PCR).":[91],"also":[93],"characterized":[94],"genomic":[96],"location":[97],"conservation":[99],"these":[101],"majority":[108],"are":[112],"from":[114],"exonic":[115],"regions.":[116],"To":[117],"understand":[119],"potential":[121],"functions":[122,186],"circRNAs,":[125],"microRNAs":[128],"binding":[131],"protein,":[132],"might":[134],"bind":[135],"This":[139,167],"process":[140],"suggested":[141],"their":[142],"involvement":[143],"development":[145,189],"organ":[147,188],"differentiation.":[148],"Finally,":[149],"constructed":[151],"an":[152],"integrated":[153],"database":[154],"TSCD":[155],"(Tissue-Specific":[156],"CircRNA":[157],"Database:":[158],"http://gb.whu.edu.cn/TSCD)":[159],"deposit":[161],"study":[168],"first":[171],"mouse,":[180],"shed":[182],"light":[183],"on":[184],"circRNA":[185],"disorders.":[191]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2507445921","counts_by_year":[{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":42},{"year":2022,"cited_by_count":60},{"year":2021,"cited_by_count":69},{"year":2020,"cited_by_count":45},{"year":2019,"cited_by_count":42},{"year":2018,"cited_by_count":34},{"year":2017,"cited_by_count":16}],"updated_date":"2024-10-30T10:43:36.981295","created_date":"2016-09-16"}
