iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: https://api.openalex.org/works/doi:10.1007/978-3-030-37599-7_52
{"id":"https://openalex.org/W2996949945","doi":"https://doi.org/10.1007/978-3-030-37599-7_52","title":"On the Role of Hub and Orphan Genes in the Diagnosis of Breast Invasive Carcinoma","display_name":"On the Role of Hub and Orphan Genes in the Diagnosis of Breast Invasive Carcinoma","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W2996949945","doi":"https://doi.org/10.1007/978-3-030-37599-7_52","mag":"2996949945"},"language":"en","primary_location":{"is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-030-37599-7_52","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319965","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Springer Nature","Springer Science+Business Media"],"type":"book series"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false},"type":"book-chapter","type_crossref":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100611054","display_name":"Marta B. Lopes","orcid":"https://orcid.org/0000-0002-4135-1857"},"institutions":[{"id":"https://openalex.org/I4210120471","display_name":"Instituto de Telecomunica\u00e7\u00f5es","ror":"https://ror.org/02ht4fk33","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I4210120471"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Marta B. Lopes","raw_affiliation_strings":["Instituto de Telecomunica\u00e7\u00f5es, Av. Rovisco Pais 1, 1049-001, Lisbon, Portugal"],"affiliations":[{"raw_affiliation_string":"Instituto de Telecomunica\u00e7\u00f5es, Av. Rovisco Pais 1, 1049-001, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210120471"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053180327","display_name":"Andr\u00e9 Ver\u00edssimo","orcid":"https://orcid.org/0000-0002-2212-339X"},"institutions":[{"id":"https://openalex.org/I121345201","display_name":"Instituto de Engenharia de Sistemas e Computadores Investiga\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/04mqy3p58","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I121345201","https://openalex.org/I4210125590"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Andr\u00e9 Ver\u00edssimo","raw_affiliation_strings":["INESC-ID, Instituto de Engenharia de Sistemas e Computadores - Investiga\u00e7\u00e3o e Desenvolvimento, Rua Alves Redol, 9, 1000-029, Lisbon, Portugal"],"affiliations":[{"raw_affiliation_string":"INESC-ID, Instituto de Engenharia de Sistemas e Computadores - Investiga\u00e7\u00e3o e Desenvolvimento, Rua Alves Redol, 9, 1000-029, Lisbon, Portugal","institution_ids":["https://openalex.org/I121345201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064430711","display_name":"Eunice Carrasquinha","orcid":"https://orcid.org/0000-0003-3465-4347"},"institutions":[{"id":"https://openalex.org/I121345201","display_name":"Instituto de Engenharia de Sistemas e Computadores Investiga\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/04mqy3p58","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I121345201","https://openalex.org/I4210125590"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Eunice Carrasquinha","raw_affiliation_strings":["INESC-ID, Instituto de Engenharia de Sistemas e Computadores - Investiga\u00e7\u00e3o e Desenvolvimento, Rua Alves Redol, 9, 1000-029, Lisbon, Portugal"],"affiliations":[{"raw_affiliation_string":"INESC-ID, Instituto de Engenharia de Sistemas e Computadores - Investiga\u00e7\u00e3o e Desenvolvimento, Rua Alves Redol, 9, 1000-029, Lisbon, Portugal","institution_ids":["https://openalex.org/I121345201"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005271169","display_name":"Susana Vinga","orcid":"https://orcid.org/0000-0002-1954-5487"},"institutions":[{"id":"https://openalex.org/I121345201","display_name":"Instituto de Engenharia de Sistemas e Computadores Investiga\u00e7\u00e3o e Desenvolvimento","ror":"https://ror.org/04mqy3p58","country_code":"PT","type":"nonprofit","lineage":["https://openalex.org/I121345201","https://openalex.org/I4210125590"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Susana Vinga","raw_affiliation_strings":["INESC-ID, Instituto de Engenharia de Sistemas e Computadores - Investiga\u00e7\u00e3o e Desenvolvimento, Rua Alves Redol, 9, 1000-029, Lisbon, Portugal"],"affiliations":[{"raw_affiliation_string":"INESC-ID, Instituto de Engenharia de Sistemas e Computadores - Investiga\u00e7\u00e3o e Desenvolvimento, Rua Alves Redol, 9, 1000-029, Lisbon, Portugal","institution_ids":["https://openalex.org/I121345201"]}]}],"institution_assertions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100611054"],"corresponding_institution_ids":["https://openalex.org/I4210120471"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392,"provenance":"doaj"},"apc_paid":null,"fwci":0.486,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.553482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":62,"max":70},"biblio":{"volume":null,"issue":null,"first_page":"631","last_page":"642"},"is_retracted":false,"is_paratext":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Analysis of Gene Interaction Networks","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Analysis of Gene Interaction Networks","score":0.9999,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Microarray Data Analysis and Gene Expression Profiling","score":0.9987,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genomic Studies and Association Analyses","score":0.9874,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biological-network-integration","display_name":"Biological Network Integration","score":0.547192},{"id":"https://openalex.org/keywords/genomic-data-integration","display_name":"Genomic Data Integration","score":0.54065},{"id":"https://openalex.org/keywords/gene-set-enrichment-analysis","display_name":"Gene Set Enrichment Analysis","score":0.518741},{"id":"https://openalex.org/keywords/breast-carcinoma","display_name":"Breast carcinoma","score":0.4925495}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.52497},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.4925495},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.37498045},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3356162},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32400373},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22775435},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20537883},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17374498}],"mesh":[],"locations_count":1,"locations":[{"is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-030-37599-7_52","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319965","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Springer Nature","Springer Science+Business Media"],"type":"book series"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.68}],"grants":[],"datasets":[],"versions":[],"referenced_works_count":29,"referenced_works":["https://openalex.org/W1833991130","https://openalex.org/W1975397962","https://openalex.org/W1994018858","https://openalex.org/W2012919261","https://openalex.org/W2024010804","https://openalex.org/W2036369755","https://openalex.org/W2045949302","https://openalex.org/W2057913094","https://openalex.org/W2063411878","https://openalex.org/W2096173332","https://openalex.org/W2097360283","https://openalex.org/W2122825543","https://openalex.org/W2123500593","https://openalex.org/W2128873464","https://openalex.org/W2135046866","https://openalex.org/W2140514146","https://openalex.org/W2145825942","https://openalex.org/W2154947819","https://openalex.org/W2164786997","https://openalex.org/W2290955096","https://openalex.org/W2413717717","https://openalex.org/W2546528671","https://openalex.org/W2565904822","https://openalex.org/W2626606138","https://openalex.org/W2803144208","https://openalex.org/W2808263699","https://openalex.org/W2889300651","https://openalex.org/W2912307265","https://openalex.org/W4294541781"],"related_works":["https://openalex.org/W2389537049","https://openalex.org/W2386018809","https://openalex.org/W2380058851","https://openalex.org/W2372990141","https://openalex.org/W2358451945","https://openalex.org/W2356539871","https://openalex.org/W2354911792","https://openalex.org/W2352439130","https://openalex.org/W2338318399","https://openalex.org/W2003115165"],"abstract_inverted_index":{"Network":[0],"information":[1,43,53,161],"is":[2],"gaining":[3],"importance":[4],"in":[5,11,30,54,99,180,190,213],"the":[6,15,22,36,46,55,81,100,105,123,127,145,181,204,207,214],"generation":[7],"of":[8,38,57,107,116,143,150,206,209],"predictive":[9,117],"models":[10,23],"cancer":[12],"genomics,":[13],"with":[14,131,176],"premise":[16],"that":[17],"prior":[18],"biological":[19,170],"knowledge":[20],"offers":[21],"interpretability":[24],"and":[25,50,72,222],"reproducibility,":[26],"an":[27],"invaluable":[28],"contribution":[29],"precision":[31,223],"medicine.":[32,224],"This":[33,194],"work":[34],"evaluates":[35],"usefulness":[37],"accounting":[39],"for":[40],"gene":[41,211],"network":[42,101,160],"provided":[44],"by":[45,75,126,136,148,154],"data":[47,63],"correlation":[48],"structure":[49],"external":[51],"STRING":[52],"classification":[56],"Breast":[58],"Invasive":[59],"Carcinoma":[60],"(BRCA)":[61],"RNA-Seq":[62],"from":[64],"The":[65],"Cancer":[66],"Genome":[67],"Atlas":[68],"(TCGA)":[69],"into":[70],"tumor":[71],"normal":[73],"tissue,":[74],"sparse":[76],"logistic":[77],"regression":[78],"(SLR).":[79],"Within":[80],"correlation-based":[82],"approaches,":[83],"two":[84],"directions":[85],"were":[86],"investigated:":[87],"first,":[88],"imposing":[89],"smaller":[90],"penalties":[91],"on":[92,158],"hub":[93],"genes,":[94,144],"i.e.,":[95],"highly":[96,187],"connected":[97,188],"genes":[98,112,124,133,151,175,189],"(hubSLR);":[102],"second,":[103],"favouring":[104],"selection":[106],"orphan":[108],"or":[109,186],"weakly":[110],"correlated":[111],"(orphanSLR).":[113],"Without":[114],"loss":[115],"ability,":[118],"a":[119,140,166,177,196],"considerable":[120],"overlap":[121],"between":[122],"selected":[125,135,153],"methods":[128],"was":[129],"achieved,":[130],"fewer":[132],"exclusively":[134,152],"each":[137,155],"method.":[138],"Besides":[139],"consensus":[141],"list":[142],"complementarity":[146],"offered":[147],"sets":[149],"model":[156],"based":[157],"different":[159],"shall":[162],"be":[163],"regarded":[164],"as":[165],"means":[167],"to":[168,174],"enhance":[169],"interpretability,":[171],"drawing":[172],"attention":[173],"known":[178,210],"role":[179],"network,":[182],"either":[183],"hubs,":[184],"orphans":[185],"protein-protein":[191],"interaction":[192],"networks.":[193],"represents":[195],"major":[197],"advantage":[198],"over":[199],"non":[200],"network-based":[201],"methods,":[202],"enabling":[203],"disclosure":[205],"relevance":[208],"subnetworks":[212],"disease":[215],"under":[216],"study,":[217],"while":[218],"boosting":[219],"biomarker":[220],"discovery":[221]},"cited_by_api_url":"https://api.openalex.org/works?filter=cites:W2996949945","counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2024-11-19T00:49:48.419679","created_date":"2020-01-10"}