{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T08:33:49Z","timestamp":1718181229089},"reference-count":59,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Government sponsored ZIM (Zentrales Innovationsprogramm Mittelstand) program","award":["4279701AW6"]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Sensors"],"abstract":"Background: Non-invasive tracking of beat-to-beat pulse transit time (PTT) via piezoelectric\/piezocapacitive sensors (PES\/PCS) may expand perioperative hemodynamic monitoring. This study evaluated the ability for PTT via PES\/PCS to correlate with systolic, diastolic, and mean invasive blood pressure (SBPIBP, DBPIBP, and MAPIBP, respectively) and to detect SBPIBP fluctuations. Methods: PES\/PCS and IBP measurements were performed in 20 patients undergoing abdominal, urological, and cardiac surgery. A Pearson\u2019s correlation analysis (r) between 1\/PTT and IBP was performed. The predictive ability of 1\/PTT with changes in SBPIBP was determined by area under the curve (reported as AUC, sensitivity, specificity). Results: Significant correlations between 1\/PTT and SBPIBP were found for PES (r = 0.64) and PCS (r = 0.55) (p < 0.01), as well as MAPIBP\/DBPIBP for PES (r = 0.6\/0.55) and PCS (r = 0.5\/0.45) (p < 0.05). A 7% decrease in 1\/PTTPES predicted a 30% SBPIBP decrease (0.82, 0.76, 0.76), while a 5.6% increase predicted a 30% SBPIBP increase (0.75, 0.7, 0.68). A 6.6% decrease in 1\/PTTPCS detected a 30% SBPIBP decrease (0.81, 0.72, 0.8), while a 4.8% 1\/PTTPCS increase detected a 30% SBPIBP increase (0.73, 0.64, 0.68). Conclusions: Non-invasive beat-to-beat PTT via PES\/PCS demonstrated significant correlations with IBP and detected significant changes in SBPIBP. Thus, PES\/PCS as a novel sensor technology may augment intraoperative hemodynamic monitoring during major surgery.<\/jats:p>","DOI":"10.3390\/s23063304","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T08:48:01Z","timestamp":1679388481000},"page":"3304","source":"Crossref","is-referenced-by-count":2,"title":["Intraoperative Beat-to-Beat Pulse Transit Time (PTT) Monitoring via Non-Invasive Piezoelectric\/Piezocapacitive Peripheral Sensors Can Predict Changes in Invasively Acquired Blood Pressure in High-Risk Surgical Patients"],"prefix":"10.3390","volume":"23","author":[{"given":"Michael","family":"Nordine","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Hindenburgdamm 30, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 12203 Berlin, Germany"}]},{"given":"Marius","family":"Pille","sequence":"additional","affiliation":[{"name":"Berlin Institute of Health at Charit\u00e9, Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117 Berlin, Germany"},{"name":"Department of Physics, Humboldt University zu Berlin, 10115 Berlin, Germany"}]},{"given":"Jan","family":"Kraemer","sequence":"additional","affiliation":[{"name":"Department of Physics, Humboldt University zu Berlin, 10115 Berlin, Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-9087-7732","authenticated-orcid":false,"given":"Christian","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Hindenburgdamm 30, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 12203 Berlin, Germany"}]},{"given":"Philipp","family":"Brandhorst","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Hindenburgdamm 30, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 12203 Berlin, Germany"}]},{"given":"Philipp","family":"Kaeferstein","sequence":"additional","affiliation":[{"name":"SectorCon-Ingenieurgesellschaft mbH, 10553 Berlin, Germany"}]},{"given":"Roland","family":"Kopetsch","sequence":"additional","affiliation":[{"name":"SectorCon-Ingenieurgesellschaft mbH, 10553 Berlin, Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-0922-9971","authenticated-orcid":false,"given":"Niels","family":"Wessel","sequence":"additional","affiliation":[{"name":"Department of Physics, Humboldt University zu Berlin, 10115 Berlin, Germany"},{"name":"Department of Human Medicine, MSB Medical School Berlin GmbH, 14197 Berlin, Germany"}]},{"given":"Ralf Felix","family":"Trauzeddel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Hindenburgdamm 30, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 12203 Berlin, Germany"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-0549-7680","authenticated-orcid":false,"given":"Sascha","family":"Treskatsch","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Intensive Care Medicine, Hindenburgdamm 30, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt Universit\u00e4t zu Berlin, 12203 Berlin, Germany"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"ref_1","first-page":"49","article-title":"Optimal Perioperative Management of Arterial Blood Pressure","volume":"7","author":"ReferencesLonjaret","year":"2014","journal-title":"IBPC"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/HYPERTENSIONAHA.118.11688","article-title":"Blood Pressure Targets in Perioperative Care: Provisional Considerations Based on a Comprehensive Literature Review","volume":"72","author":"Meng","year":"2018","journal-title":"Hypertension"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.aan.2018.07.003","article-title":"Optimal Perioperative Blood Pressure Management","volume":"36","author":"Packiasabapathy","year":"2018","journal-title":"Adv. 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