{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T22:12:59Z","timestamp":1719699179794},"reference-count":51,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T00:00:00Z","timestamp":1573603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Robotics"],"abstract":"A deep analysis of ankle mechanical properties is a fundamental step in the design of an exoskeleton, especially if it is to be suitable for both adults and children. This study aims at assessing age-related differences of ankle properties using pediAnklebot. To achieve this aim, we enrolled 16 young adults and 10 children in an experimental protocol that consisted of the evaluation of ankle mechanical impedance and kinematic performance. Ankle impedance was measured by imposing stochastic torque perturbations in dorsi-plantarflexion and inversion-eversion directions. Kinematic performance was assessed by asking participants to perform a goal-directed task. Magnitude and anisotropy of impedance were computed using a multiple-input multiple-output system. Kinematic performance was quantified by computing indices of accuracy, smoothness, and timing. Adults showed greater magnitude of ankle impedance in both directions and for all frequencies, while the anisotropy was higher in children. By analyzing kinematics, children performed movements with lower accuracy and higher smoothness, while no differences were found for the duration of the movement. In addition, adults showed a greater ability to stop the movement when hitting the target. These findings can be useful to a proper development of robotic devices, as well as for implementation of specific training programs.<\/jats:p>","DOI":"10.3390\/robotics8040096","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T15:56:34Z","timestamp":1573746994000},"page":"96","source":"Crossref","is-referenced-by-count":3,"title":["Quantifying Age-Related Differences of Ankle Mechanical Properties Using a Robotic Device"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"http:\/\/orcid.org\/0000-0002-8996-6770","authenticated-orcid":false,"given":"Francesca","family":"Martelli","sequence":"first","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, 00184 Rome, Italy"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-8997-7605","authenticated-orcid":false,"given":"Juri","family":"Taborri","sequence":"additional","affiliation":[{"name":"Department of Economics, Engineering, Society and Business Organization (DEIM), University of Tuscia, 01100 Viterbo, Italy"}]},{"ORCID":"http:\/\/orcid.org\/0000-0001-6057-7774","authenticated-orcid":false,"given":"Zaccaria","family":"Del Prete","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, 00184 Rome, Italy"}]},{"ORCID":"http:\/\/orcid.org\/0000-0002-3213-8261","authenticated-orcid":false,"given":"Eduardo","family":"Palermo","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering, Sapienza University of Rome, 00184 Rome, Italy"}]},{"ORCID":"http:\/\/orcid.org\/0000-0003-0006-7013","authenticated-orcid":false,"given":"Stefano","family":"Rossi","sequence":"additional","affiliation":[{"name":"Department of Economics, Engineering, Society and Business Organization (DEIM), University of Tuscia, 01100 Viterbo, Italy"}]}],"member":"1968","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1743-0003-6-20","article-title":"Review of control strategies for robotic movement training after neurologic injury","volume":"6","author":"Reinkensmeyer","year":"2009","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1136\/adc.2008.145458","article-title":"Improvement of walking abilities after robotic-assisted locomotion training in children with cerebral palsy","volume":"94","author":"Schmartz","year":"2009","journal-title":"Arch. Dis. Child."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Adiputra, D., Nazmi, N., Bahiuddin, I., Ubaidillah, U., Imaduddin, F., Rahman, M.A.A., Mazlan, S.A., and Zamzuri, H. (2019). A Review on the Control of the Mechanical Properties of Ankle Foot Orthosis for Gait Assistance. Actuators, 8.","DOI":"10.3390\/act8010010"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1177\/0890117117744913","article-title":"Differential Experimental Effects of a Short Bout of Walking, Meditation, or Combination of Walking and Meditation on State Anxiety Among Young Adults","volume":"32","author":"Edwards","year":"2018","journal-title":"Am. J. Health Promot."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Alvarez-Perez, M.G., Garcia-Murillo, M.A., and Cervantes-S\u00e1nchez, J.J. (2019). Robot-assisted ankle rehabilitation: A review. Disabil. Rehabil. Assist. Technol., 1\u201315.","DOI":"10.1080\/17483107.2019.1578424"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1007\/s10439-018-2092-9","article-title":"Sex Differences in 2-DOF Human Ankle Stiffness in Relaxed and Contracted Muscles","volume":"46","author":"Trevino","year":"2018","journal-title":"Ann. Biomed. Eng."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1242\/jeb.017269","article-title":"Powered ankle exoskeletons reveal the metabolic cost of plantar flexor mechanical work during walking with longer steps at constant step frequency","volume":"212","author":"Sawicki","year":"2009","journal-title":"J. Exp. Biol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"031001","DOI":"10.1088\/1741-2560\/13\/3\/031001","article-title":"Powered exoskeletons for bipedal locomotion after spinal cord injury","volume":"13","author":"Brantley","year":"2016","journal-title":"J. Neural Eng."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1109\/TMECH.2012.2219065","article-title":"An Adaptive Wearable Parallel Robot for the Treatment of Ankle Injuries","volume":"19","author":"Jamwal","year":"2014","journal-title":"IEEE\/ASME Trans. Mechatron."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1109\/TMECH.2006.871087","article-title":"Biomechanical design of the Berkeley lower extremity exoskeleton (BLEEX)","volume":"11","author":"Zoss","year":"2006","journal-title":"IEEE\/ASME Trans. Mechatron."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1142\/S0219843607001126","article-title":"A quasi-passive leg exoskeleton for load-carrying augmentation","volume":"4","author":"Walsh","year":"2007","journal-title":"Int. J. Humanoid Robot."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/1534247","article-title":"Towards Optimal Platform-Based Robot Design for Ankle Rehabilitation: The State of the Art and Future Prospects","volume":"2018","author":"Miao","year":"2018","journal-title":"J. Healthc. Eng."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Martelli, F., Palermo, E., and Rossi, S. (2017, January 17\u201320). A novel protocol to evaluate ankle movements during reaching tasks using pediAnklebot. Proceedings of the 2017 International Conference on Rehabilitation Robotics (ICORR), London, UK.","DOI":"10.1109\/ICORR.2017.8009268"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Martelli, F., Bertini, E., del Prete, Z., Palermo, E., and Rossi, S. (2018, January 11\u201313). Submovement changes in goal-directed and non-goal-directed ankle movements using pediAnklebot. Proceedings of the 2018 IEEE International Symposium on Medical Measurements and Applications (MeMeA), Rome, Italy.","DOI":"10.1109\/MeMeA.2018.8438677"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Perez-Ibarra, J.C., Gomez-Pena, G., and Siqueira, A.A.G. (November, January 28). Estimation of Patient Participation during Therapeutic Movements Using the Anklebot: Technique and Preliminary Results. Proceedings of the 2015 12th Latin American Robotics Symposium and 2015 3rd Brazilian Symposium on Robotics (LARS-SBR), Uberl\u00e2ndia, Brazil.","DOI":"10.1109\/LARS-SBR.2015.63"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1469-8749.2009.03416.x","article-title":"Robot-assisted task-specific training in cerebral palsy","volume":"51","author":"Krebs","year":"2009","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00221-013-3773-0","article-title":"Pointing with the ankle: The speed-accuracy trade-off","volume":"232","author":"Michmizos","year":"2014","journal-title":"Exp. Brain Res."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnhum.2014.00962","article-title":"A comparative analysis of speed profile models for ankle pointing movements: Evidence that lower and upper extremity discrete movements are controlled by a single invariant strategy","volume":"8","author":"Michmizos","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.jbiomech.2004.01.017","article-title":"The human ankle during walking: Implications for design of biomimetic ankle prostheses","volume":"37","author":"Hansen","year":"2004","journal-title":"J. Biomech."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1109\/TMECH.2019.2892472","article-title":"Development of a Two-Axis Robotic Platform for the Characterization of Two-Dimensional Ankle Mechanics","volume":"24","author":"Nalam","year":"2019","journal-title":"IEEE\/ASME Trans. Mechatron."},{"key":"ref_21","unstructured":"Lee, H., Patterson, T., Ahn, J., Klenk, D., Lo, A., Krebs, H.I., and Hogan, N. (September, January 30). Static ankle impedance in stroke and multiple sclerosis: A feasibility study. Proceedings of the 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society EMBS, Boston, MA, USA."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s41315-017-0033-7","article-title":"Using lower extremity muscle activity to obtain human ankle impedance in the external\u2013internal direction","volume":"2","author":"Dallali","year":"2018","journal-title":"Int. J. Intell. Robot. Appl."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Martelli, F., Rossi, S., Frascarelli, F., Germanotta, M., Petrarca, M., Castelli, E., and Cappa, P. (2016, January 15\u201318). Estimation of multivariable dynamic ankle impedance after botulinum toxin injection in children with cerebral palsy. Proceedings of the 2016 IEEE International Symposium on Medical Measurements and Applications (MeMeA), Benevento, Italy.","DOI":"10.1109\/MeMeA.2016.7533709"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jelekin.2019.02.001","article-title":"Single-trial estimation of quasi-static EMG-to-joint-mechanical-impedance relationship over a range of joint torques","volume":"45","author":"Dai","year":"2019","journal-title":"J. Electromyogr. Kinesiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1109\/TNSRE.2014.2328235","article-title":"Multivariable dynamic ankle mechanical impedance with active muscles","volume":"22","author":"Lee","year":"2014","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Rastgaar, M.A., Ho, P., Lee, H., Krebs, H.I., and Hogan, N. (2010, January 12\u201315). Stochastic Estimation of the Multi-Variable Mechanical Impedance of the Human Ankle with Active Muscles. Proceedings of the ASME 2010 Dynamic Systems and Control Conference, Cambridge, MA, USA.","DOI":"10.1115\/DSCC2010-4224"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0021-9290(82)90089-6","article-title":"Dynamics of human ankle stiffness: Variation with mean ankle torque","volume":"15","author":"Hunter","year":"1982","journal-title":"J. Biomech."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/0021-9290(82)90090-2","article-title":"Dynamics of human ankle stiffness: Variation with displacement amplitude","volume":"15","author":"Kearney","year":"1982","journal-title":"J. Biomech."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1109\/TRO.2009.2019783","article-title":"Robot-aided neurorehabilitation: A novel robot for ankle rehabilitation","volume":"25","author":"Roy","year":"2009","journal-title":"IEEE Trans. Robot."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1469-8749.2009.03600.x","article-title":"Mechanical properties of the plantarflexor musculotendinous unit during passive dorsiflexion in children with cerebral palsy compared with typically developing children","volume":"52","author":"Alhusaini","year":"2010","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1109\/TNSRE.2015.2410773","article-title":"Robot-Aided Neurorehabilitation: A Pediatric Robot for Ankle Rehabilitation","volume":"23","author":"Michmizos","year":"2015","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1109\/TNSRE.2017.2651404","article-title":"WAKE-Up Exoskeleton to Assist Children with Cerebral Palsy: Design and Preliminary Evaluation in Level Walking","volume":"25","author":"Rossi","year":"2017","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Mileti, I., Taborri, J., Rossi, S., Petrarca, M., Patan\u00e8, F., and Cappa, P. (2016, January 15\u201318). Evaluation of the effects on stride-to-stride variability and gait asymmetry in children with Cerebral Palsy wearing the WAKE-up ankle module. Proceedings of the 2016 IEEE International Symposium on Medical Measurements and Applications (MeMeA), Benevento, Italy.","DOI":"10.1109\/MeMeA.2016.7533748"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fnhum.2017.00277","article-title":"Spasticity Measurement Based on Tonic Stretch Reflex Threshold in Children with Cerebral Palsy Using the PediAnklebot","volume":"11","author":"Germanotta","year":"2017","journal-title":"Front. Hum. Neurosci."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kardofaki, M., Tabti, N., Alfayad, S., Ouezdou, F.B., Chitour, Y., and Dychus, E. (2019, January 24\u201328). Mechanical Development of a Scalable Structure for Adolescent Exoskeletons. Proceedings of the 2019 IEEE 16th International Conference on Rehabilitation Robotics (ICORR), Toronto, ON, Canada.","DOI":"10.1109\/ICORR.2019.8779395"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Taborri, J., Palermo, E., Masiello, D., and Rossi, S. (2017, January 22\u201325). Factorization of EMG via muscle synergies in walking task: Evaluation of intra-subject and inter-subject variability. Proceedings of the I2MTC 2017\u20142017 IEEE International Instrumentation and Measurement Technology Conference, Turin, Italy.","DOI":"10.1109\/I2MTC.2017.7969775"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Krebs, H.I., Michmizos, K.P., Monterosso, L., and Mast, J. (2016, January 26\u201329). Pediatric anklebot: pilot clinical trial. Proceedings of the 2016 6th IEEE International Conference on Biomedical Robotics and Biomechatronics (BioRob), Singapore.","DOI":"10.1109\/BIOROB.2016.7523701"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s004220050529","article-title":"Multiple-input, multiple-output system identification for characterization of limb stiffness dynamics","volume":"80","author":"Perreault","year":"1999","journal-title":"Biol. Cybern."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1109\/TNSRE.2014.2313838","article-title":"Multivariable dynamic ankle mechanical impedance with relaxed muscles","volume":"22","author":"Lee","year":"2014","journal-title":"IEEE Trans. Neural Syst. Rehabil. Eng."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1152\/jn.01095.2006","article-title":"Motor Adaptation as a Greedy Optimization of Error and Effort","volume":"97","author":"Emken","year":"2007","journal-title":"J. Neurophysiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1006\/exnr.1997.6507","article-title":"Parkinsonism reduces coordination of fingers, wrist, and arm in fine motor control","volume":"146","author":"Teulings","year":"1997","journal-title":"Exp. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1152\/jappl.1999.86.3.1040","article-title":"Maturation of gait dynamics: Stride-to-stride variability and its temporal organization in children","volume":"86","author":"Hausdorff","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1055\/s-2001-11337","article-title":"Growth Changes in the Elastic Properties of Human Tendon Structures","volume":"22","author":"Kubo","year":"2001","journal-title":"Int. J. Sports Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1152\/japplphysiol.00885.2002","article-title":"Evaluation of musculotendinous stiffness in prepubertal children and adults, taking into account muscle activity","volume":"95","author":"Lambertz","year":"2003","journal-title":"J. Appl. Physiol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF00355754","article-title":"The mechanics of multi-joint posture and movement control","volume":"52","author":"Hogan","year":"1985","journal-title":"Biol. Cybern."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1177\/036354659502300508","article-title":"A Prospective Study of Ankle Injury Risk Factors","volume":"23","author":"Baumhauer","year":"1995","journal-title":"Am. J. Sports Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1002\/art.30435","article-title":"Epidemiology of generalized joint laxity (hypermobility) in fourteen-year-old children from the UK: A population-based evaluation","volume":"63","author":"Clinch","year":"2011","journal-title":"Arthritis Rheum."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1757-1146-7-21","article-title":"Systematic review of chronic ankle instability in children","volume":"7","author":"Mandarakas","year":"2014","journal-title":"J. Foot Ankle Res."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.humov.2005.05.004","article-title":"Development of upper limb proprioceptive accuracy in children and adolescents","volume":"24","author":"Goble","year":"2005","journal-title":"Hum. Mov. Sci."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.humov.2006.07.003","article-title":"Effects of increased complexity of visuo-motor transformations on children\u2019s arm movements","volume":"25","author":"Bo","year":"2006","journal-title":"Hum. Mov. Sci."},{"key":"ref_51","unstructured":"Nordin, M., and Frankel, V.H. (2001). Basic Biomechanics of the Musculoskeletal System, Lippincott Williams & Wilkins."}],"container-title":["Robotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2218-6581\/8\/4\/96\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T05:15:39Z","timestamp":1719033339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2218-6581\/8\/4\/96"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,13]]},"references-count":51,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,12]]}},"alternative-id":["robotics8040096"],"URL":"http:\/\/dx.doi.org\/10.3390\/robotics8040096","relation":{},"ISSN":["2218-6581"],"issn-type":[{"value":"2218-6581","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,13]]}}}
