{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T08:33:36Z","timestamp":1706517216212},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T00:00:00Z","timestamp":1385596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Bioinformatics"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1471-2105-14-343","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T21:04:18Z","timestamp":1385586258000},"source":"Crossref","is-referenced-by-count":18,"title":["Transferring functional annotations of membrane transporters on the basis of sequence similarity and sequence motifs"],"prefix":"10.1186","volume":"14","author":[{"given":"Ahmad","family":"Barghash","sequence":"first","affiliation":[]},{"given":"Volkhard","family":"Helms","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2013,11,28]]},"reference":[{"key":"6212_CR1","doi-asserted-by":"publisher","first-page":"D274","DOI":"10.1093\/nar\/gkn862","volume":"37","author":"MH Saier Jr","year":"2009","unstructured":"Saier MH, Yen MR, Noto K, Tamang DG, Elkan C: The Transporter Classification Database: recent advances. Nucleic Acids Res. 2009, 37: D274-D278. 10.1093\/nar\/gkn862.","journal-title":"Nucleic Acids Res"},{"key":"6212_CR2","doi-asserted-by":"publisher","first-page":"D274","DOI":"10.1093\/nar\/gkl925","volume":"35","author":"Q Ren","year":"2007","unstructured":"Ren Q, Chen K, Paulsen IT: TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Nucleic Acids Res. 2007, 35: D274-D279. 10.1093\/nar\/gkl925.","journal-title":"Nucleic Acids Res"},{"key":"6212_CR3","doi-asserted-by":"publisher","first-page":"D700","DOI":"10.1093\/nar\/gkr1029","volume":"40","author":"JM Cherry","year":"2012","unstructured":"Cherry JM, Hong EL, Amundsen C, Balakrishnan R, Binkley G, Chan ET, Christie KR, Costanzo MC, Dwight SS, Engel SR, Fisk DG, Hirschman JE, Hitz BC, Karra K, Krieger CJ, Miyasato SR, Nash RS, Park J, Skrzypek MS, Simison M, Weng S, Wong ED: Saccharomyces Genome Database: the genomics resource of budding yeast. Nucleic Acids Res. 2012, 40: D700-D705. 10.1093\/nar\/gkr1029.","journal-title":"Nucleic Acids Res"},{"key":"6212_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1104\/pp.011577","volume":"131","author":"R Schwacke","year":"2003","unstructured":"Schwacke R, Schneider A, Van Der Graaff E, Fischer K, Catoni E, Desimone M, Frommer WB, Flugge UI, Kunze R: ARAMEMNON, a Novel Database for Arabidopsis Integral Membrane Proteins. Plant Physiol. 2003, 131: 16-26. 10.1104\/pp.011577.","journal-title":"Plant Physiol"},{"key":"6212_CR5","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1080\/10409230290771528","volume":"37","author":"W Busch","year":"2002","unstructured":"Busch W, Saier MH: The Transporter Classification (TC) System. Crit Rev Biochem Mol Biol. 2002, 37: 287-337. 10.1080\/10409230290771528.","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"6212_CR6","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1021\/ci100243m","volume":"50","author":"NS Schaadt","year":"2010","unstructured":"Schaadt NS, Christoph J, Helms V: Classifying Substrate Specificities of Membrane Transporters from Arabidopsis thaliana. J Chem Inf Model. 2010, 50: 1899-1905. 10.1021\/ci100243m.","journal-title":"J Chem Inf Model"},{"key":"6212_CR7","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/bip.22043","volume":"97","author":"NS Schaadt","year":"2012","unstructured":"Schaadt NS, Helms V: Functional classification of membrane transporters and channels based on filtered TM\/non-TM amino acid composition. Biopolymers. 2012, 97: 558-567. 10.1002\/bip.22043.","journal-title":"Biopolymers"},{"key":"6212_CR8","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1093\/bioinformatics\/btn099","volume":"24","author":"H Li","year":"2008","unstructured":"Li H, Dai X, Zhao X: A nearest neighbor approach for automated transporter prediction and categorization from protein sequences. Bioinformatics. 2008, 24: 1129-1136. 10.1093\/bioinformatics\/btn099.","journal-title":"Bioinformatics"},{"key":"6212_CR9","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1186\/1471-2105-10-418","volume":"10","author":"L Haiquan","year":"2009","unstructured":"Haiquan L, Benedito VA, Udvardi MK, Zhao PX: TransportTP: A two-phase classification approach for membrane transporter prediction and characterization. BMC Bioinformatics. 2009, 10: 418-10.1186\/1471-2105-10-418.","journal-title":"BMC Bioinformatics"},{"key":"6212_CR10","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2105-9-135","volume":"9","author":"Y Yabuki","year":"2008","unstructured":"Yabuki Y, Gromiha MM: Functional discrimination of membrane proteins using machine learning techniques. BMC Bioinformatics. 2008, 9: 135-10.1186\/1471-2105-9-135.","journal-title":"BMC Bioinformatics"},{"key":"6212_CR11","doi-asserted-by":"publisher","first-page":"D290","DOI":"10.1093\/nar\/gkr1065","volume":"40","author":"M Punta","year":"2012","unstructured":"Punta M, Coggill PC, Eberhardt RY, Mistry J, Tate J, Boursnell C, Pang N, Forslund K, Ceric G, Clements J, Heger A, Holm L, Sonnhammer EL, Eddy SR, Bateman A, Finn RD: The Pfam protein families database. Nucleic Acids Res. 2012, 40: D290-D301. 10.1093\/nar\/gkr1065.","journal-title":"Nucleic Acids Res"},{"key":"6212_CR12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1080\/09687680410001720830","volume":"21","author":"AB Chang","year":"2004","unstructured":"Chang AB, Lin R, Keith Studley W, Tran CV, Saier MH: Phylogeny as a guide to structure and function of membrane transport proteins. Mol Membr Biol. 2004, 21: 171-181. 10.1080\/09687680410001720830.","journal-title":"Mol Membr Biol"},{"key":"6212_CR13","doi-asserted-by":"publisher","first-page":"e383","DOI":"10.1371\/journal.pone.0000383","volume":"2","author":"F Chen","year":"2007","unstructured":"Chen F, Mackey AJ, Vermunt JK, Roos DS: Assessing Performance of Orthology Detection Strategies Applied to Eukaryotic Genomes. PLoS ONE. 2007, 2: e383-10.1371\/journal.pone.0000383.","journal-title":"PLoS ONE"},{"key":"6212_CR14","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1006\/jmbi.2000.5197","volume":"314","author":"M Remm","year":"2001","unstructured":"Remm M, Storm CEV, Sonnhammer EL: Automatic Clustering of Orthologs and In-paralogs from Pairwise Species Comparisons. J Mol Biol. 2001, 314: 1041-1052. 10.1006\/jmbi.2000.5197.","journal-title":"J Mol Biol"},{"key":"6212_CR15","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/35048692","volume":"408","author":"The Arabidopsis Genome Initiative","year":"2000","unstructured":"The Arabidopsis Genome Initiative: Analysis of the genome sequence of the fowering plant Arabidopsis thaliana. Nature. 2000, 408: 796-815. 10.1038\/35048692.","journal-title":"Nature"},{"key":"6212_CR16","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","volume":"215","author":"SF Altschul","year":"1990","unstructured":"Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ: Basic local alignment search tool. J Mol Biol. 1990, 215: 403-410.","journal-title":"J Mol Biol"},{"key":"6212_CR17","first-page":"205","volume":"23","author":"RE Sean","year":"2009","unstructured":"Sean RE: A new generation of homology search tools based on probabilistic inference. Genome Inform. 2009, 23: 205-211.","journal-title":"Genome Inform"},{"key":"6212_CR18","first-page":"28","volume":"2","author":"C Elkan","year":"1994","unstructured":"Elkan C, Bailey TL: Fitting a mixture model by expectation maximization to discover motifs in biopolymers. Proc Int Conf Intell Syst Mol Bio. 1994, 2: 28-36.","journal-title":"Proc Int Conf Intell Syst Mol Bio"},{"key":"6212_CR19","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1471-2105-11-80","volume":"11","author":"MC Frith","year":"2010","unstructured":"Frith MC, Hamada M, Horton P: Parameters for accurate genome alignment. BMC Bioinformatics. 2010, 11: 80-10.1186\/1471-2105-11-80.","journal-title":"BMC Bioinformatics"},{"key":"6212_CR20","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1093\/bioinformatics\/bts608","volume":"28","author":"S Ashkenazi","year":"2012","unstructured":"Ashkenazi S, Snir R, Ofran Y: Assessing the Relationship between Conservation of Function and Conservation of Sequence Using Photosynthetic Proteins. Bioinformatics. 2012, 28: 3203-3210. 10.1093\/bioinformatics\/bts608.","journal-title":"Bioinformatics"},{"key":"6212_CR21","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.jmb.2003.08.057","volume":"333","author":"W Tian","year":"2003","unstructured":"Tian W, Skolnick J: How well is enzyme function conserved as a function of pairwise sequence identity?. J Mol Biol. 2003, 333: 863-882. 10.1016\/j.jmb.2003.08.057.","journal-title":"J Mol Biol"},{"key":"6212_CR22","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1146\/annurev.nutr.18.1.441","volume":"18","author":"DJ Eide","year":"1998","unstructured":"Eide DJ: The molecular biology of metal ion transport in Saccharomyces Cerevisiae. Annu Rev Nutr. 1998, 18: 441-469. 10.1146\/annurev.nutr.18.1.441.","journal-title":"Annu Rev Nutr"},{"key":"6212_CR23","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/0014-5793(95)01492-6","volume":"379","author":"CW Peterson","year":"1996","unstructured":"Peterson CW, Narula SS, Armitage IM: 3D solution structure of copper and silver-substituted yeast metallothioneins. FEBS Lett. 1996, 379: 85-93. 10.1016\/0014-5793(95)01492-6.","journal-title":"FEBS Lett"},{"key":"6212_CR24","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1104\/pp.126.2.875","volume":"26","author":"LC Williamson","year":"2001","unstructured":"Williamson LC, Ribrioux SPCP, Fitter AH, Leyser HMO: Phosphate availability regulates root system architecture in Arabidopsis. Plant Physiol. 2001, 26: 875-882.","journal-title":"Plant Physiol"},{"key":"6212_CR25","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1104\/pp.116.2.447","volume":"116","author":"DP Schachtman","year":"1998","unstructured":"Schachtman DP, Reid RJ, Ayling SM: Phosphorus Uptake by Plants: From Soil to Cell. Plant Physiol. 1998, 116: 447-453. 10.1104\/pp.116.2.447.","journal-title":"Plant Physiol"},{"key":"6212_CR26","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1111\/j.1365-313X.2004.02161.x","volume":"39","author":"H Shin","year":"2004","unstructured":"Shin H, Shin H-S, Dewbre GR, Harrison MJ: Phosphate transport in Arabidopsis: Pht1;1 and Pht1;4 play a major role in phosphate acquisition from both low- and high-phosphate environments. Plant Journal. 2004, 39: 629-642. 10.1111\/j.1365-313X.2004.02161.x.","journal-title":"Plant Journal"},{"key":"6212_CR27","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/S1360-1385(00)01681-2","volume":"5","author":"LE Williams","year":"2000","unstructured":"Williams LE, Lemoine R, Sauer N: Sugar transporters in higher plants-a diversity of roles and complex regulation. Trends Plant Sci. 2000, 5: 283-290. 10.1016\/S1360-1385(00)01681-2.","journal-title":"Trends Plant Sci"},{"key":"6212_CR28","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1093\/bioinformatics\/14.1.48","volume":"14","author":"M Gribskov","year":"1998","unstructured":"Gribskov M, Bailey TL: Combining evidence using p-values: application to sequence homology searches. Bioinformatics. 1998, 14: 48-54. 10.1093\/bioinformatics\/14.1.48.","journal-title":"Bioinformatics"},{"key":"6212_CR29","doi-asserted-by":"publisher","first-page":"D181","DOI":"10.1093\/nar\/gkp1042","volume":"38","author":"A Marsico","year":"2009","unstructured":"Marsico A, Scheubert K, Tuukkanen A, Henschel A, Winter C, Winnenburg R, Schroeder M: MeMotif: a database of linear motifs in \u03b1-helical transmembrane proteins. Nucleic Acids Res. 2009, 38: D181-D189.","journal-title":"Nucleic Acids Res"},{"key":"6212_CR30","doi-asserted-by":"publisher","first-page":"e1000071","DOI":"10.1371\/journal.pcbi.1000071","volume":"4","author":"MC Frith","year":"2008","unstructured":"Frith MC, Saunders NFW, Kobe B, Bailey TL: Discovering Sequence Motifs with Arbitrary Insertions and Deletions. PLoS Comput Biol. 2008, 4: e1000071-10.1371\/journal.pcbi.1000071.","journal-title":"PLoS Comput Biol"},{"key":"6212_CR31","doi-asserted-by":"publisher","first-page":"10702","DOI":"10.1021\/bi101256x","volume":"49","author":"K Khafizov","year":"2010","unstructured":"Khafizov K, Staritzbichler R, Mar S, Forrest LR: A Study of the Evolution of Inverted-Topology Repeats from LeuT-Fold Transporters Using AlignMe. Biochemistry. 2010, 49: 10702-10713. 10.1021\/bi101256x.","journal-title":"Biochemistry"},{"key":"6212_CR32","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1006\/jmbi.1998.1609","volume":"277","author":"IT Paulsen","year":"1998","unstructured":"Paulsen IT, Sliwinski MK, Saier MH: Microbial genome analyses: global comparisons of transport capabilities based on phylogenies, bioenergetics and substrate specificities. J Mol Biol. 1998, 277: 573-592. 10.1006\/jmbi.1998.1609.","journal-title":"J Mol Biol"},{"key":"6212_CR33","doi-asserted-by":"publisher","first-page":"D281","DOI":"10.1093\/nar\/gkm960","volume":"36","author":"RD Finn","year":"2010","unstructured":"Finn RD, Mistry J, Tate J, Coggill P, Heger A, Pollington JE, Gavin OL, Gunesekaran P, Ceric G, Forslund K, Holm L, Sonnhammer EL, Eddy SR, Bateman A: The Pfam protein families database. Nucleic Acids Res. 2010, 36: D281-D288.","journal-title":"Nucleic Acids Res"},{"key":"6212_CR34","doi-asserted-by":"publisher","first-page":"D1100","DOI":"10.1093\/nar\/gkr777","volume":"40","author":"A Gaulton","year":"2011","unstructured":"Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP: ChEMBL: a large-scale bioactivity database for drug discovery. Nucleic Acids Res. 2011, 40: D1100-D1107.","journal-title":"Nucleic Acids Res"},{"key":"6212_CR35","doi-asserted-by":"publisher","first-page":"D43","DOI":"10.1093\/nar\/gks1068","volume":"41","author":"Consortium","year":"2013","unstructured":"Consortium: The UniProt. Update on activities at the Universal Protein Resource (UniProt) in 2013. Nucleic Acids Res. 2013, 41: D43-D47.","journal-title":"Nucleic Acids Res"},{"key":"6212_CR36","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1073\/pnas.85.8.2444","volume":"85","author":"WR Pearson","year":"1988","unstructured":"Pearson WR, Lipma DJ: Improved tools for biological sequence comparison. Proc Natl Acad Sci. 1988, 85: 2444-2448. 10.1073\/pnas.85.8.2444.","journal-title":"Proc Natl Acad Sci"}],"container-title":["BMC Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-14-343.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2105-14-343\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2105-14-343.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T05:56:45Z","timestamp":1548136605000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcbioinformatics.biomedcentral.com\/articles\/10.1186\/1471-2105-14-343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,28]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["6212"],"URL":"https:\/\/doi.org\/10.1186\/1471-2105-14-343","relation":{},"ISSN":["1471-2105"],"issn-type":[{"value":"1471-2105","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,28]]},"article-number":"343"}}