{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T01:20:14Z","timestamp":1711761614222},"reference-count":24,"publisher":"World Scientific Pub Co Pte Ltd","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Bioinform. Comput. Biol."],"published-print":{"date-parts":[[2010,12]]},"abstract":"We re-examine the evolutionary dynamics of RNA secondary structures under directional selection towards an optimum RNA structure. We find that the punctuated equilibria lead to a very slow approach to the optimum, following on average an inverse power of the evolutionary time. In addition, our study of the trajectories shows that the out-of-equilibrium effects due to the evolutionary process are very weak. In particular, the distribution of genotypes is close to that arising during equilibrium stabilizing selection. As a consequence, the evolutionary dynamics leave almost no measurable out-of-equilibrium trace, only the transition genotypes (close to the border between different periods of stasis) have atypical mutational properties.<\/jats:p>","DOI":"10.1142\/s0219720010005075","type":"journal-article","created":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T09:25:58Z","timestamp":1283333158000},"page":"1027-1040","source":"Crossref","is-referenced-by-count":3,"title":["QUANTIFYING SLOW EVOLUTIONARY DYNAMICS IN RNA FITNESS LANDSCAPES"],"prefix":"10.1142","volume":"08","author":[{"given":"PETR","family":"\u0160ULC","sequence":"first","affiliation":[{"name":"Univ Paris-Sud, UMR8626, LPTMS, Orsay, F-91405, France"},{"name":"CNRS, Orsay, F-91405, France"}]},{"given":"ANDREAS","family":"WAGNER","sequence":"additional","affiliation":[{"name":"University of Z\u00fcrich, Department of Biochemistry, Winterthurerstrasse 190, CH-8057 Z\u00fcrich, Switzerland"},{"name":"The Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA"}]},{"given":"OLIVIER C.","family":"MARTIN","sequence":"additional","affiliation":[{"name":"Univ Paris-Sud, UMR8626, LPTMS, Orsay, F-91405, France"},{"name":"CNRS, Orsay, F-91405, France"},{"name":"UMR de G\u00e9n\u00e9tique V\u00e9g\u00e9tale, INRA \u2014 Univ Paris-Sud \u2014 CNRS \u2014 AgroParisTech, Ferme du Moulon, F-91190 Gif-sur-Yvette, France"}]}],"member":"219","published-online":{"date-parts":[[2011,11,21]]},"reference":[{"key":"rf1","doi-asserted-by":"crossref","volume-title":"Fitness Landscapes and the Origin of Species","author":"Gavrilets S.","year":"2004","DOI":"10.1515\/9780691187051"},{"key":"rf2","volume-title":"Spin Glasses and Random Fields","author":"Young A. P.","year":"1998"},{"key":"rf3","volume-title":"Stochastic Local Search:Foundations and Applications","author":"Hoos H. H.","year":"2005"},{"key":"rf4","volume":"31","author":"Eldredge N.","journal-title":"Paleobiology"},{"key":"rf5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.397"},{"key":"rf6","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5368.1451"},{"key":"rf7","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1994.0040"},{"key":"rf8","doi-asserted-by":"publisher","DOI":"10.1006\/jtbi.1998.0771"},{"key":"rf9","volume-title":"The RNA World","author":"Gesteland R. F.","year":"1993"},{"key":"rf11","volume":"47","author":"Fontana W.","journal-title":"Phys. Rev. E."},{"key":"rf12","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2007.1137"},{"key":"rf13","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bth129"},{"key":"rf14","doi-asserted-by":"publisher","DOI":"10.1007\/BF01165154"},{"key":"rf15","doi-asserted-by":"publisher","DOI":"10.1088\/0305-4470\/29\/14\/012"},{"key":"rf16","first-page":"1705","volume":"2","author":"Bouchaud J.-P.","journal-title":"J. Phys. I."},{"key":"rf17","doi-asserted-by":"crossref","volume-title":"Random Walks and Random Environments","author":"Hughes B. D.","year":"1996","DOI":"10.1093\/oso\/9780198537892.001.0001"},{"key":"rf18","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(87)80029-2"},{"key":"rf19","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-04685-2"},{"key":"rf20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.17.9716"},{"key":"rf21","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/9.1.133"},{"key":"rf22","first-page":"87","author":"Kimura M.","journal-title":"J. Mol. Evol."},{"key":"rf23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.1.397"},{"key":"rf25","first-page":"236","volume":"1","author":"Meyers L. A.","journal-title":"PLoS Comput. Biol."},{"key":"rf26","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ecolsys.38.091206.095507"}],"container-title":["Journal of Bioinformatics and Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.worldscientific.com\/doi\/pdf\/10.1142\/S0219720010005075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:17:18Z","timestamp":1711757838000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.worldscientific.com\/doi\/abs\/10.1142\/S0219720010005075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":24,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2011,11,21]]},"published-print":{"date-parts":[[2010,12]]}},"alternative-id":["10.1142\/S0219720010005075"],"URL":"http:\/\/dx.doi.org\/10.1142\/s0219720010005075","relation":{},"ISSN":["0219-7200","1757-6334"],"issn-type":[{"value":"0219-7200","type":"print"},{"value":"1757-6334","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}
