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Link to original content: http://www.ncbi.nlm.nih.gov/pubmed/7098449
Markedly prolonged theophylline half-life in liver failure - PubMed Skip to main page content
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Case Reports
. 1982 Mar-Apr;6(2):62-3.
doi: 10.1093/jat/6.2.62.

Markedly prolonged theophylline half-life in liver failure

R C Baselt, T E Albertson
Case Reports

Markedly prolonged theophylline half-life in liver failure

R C Baselt et al. J Anal Toxicol. 1982 Mar-Apr.

Abstract

Theophylline toxicity developed within 48 hours of admission in a 63-year-old alcoholic male who presented with shortness of breath, edema, and lethargy. Using liquid chromatography, a serum theophylline half-life of 134 hours was observed following discontinuation of the drug. This report emphasizes the effect of hepatic disease on theophylline clearance and the need for frequent monitoring of plasma theophylline concentrations in cirrhotic patients.

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