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Link to original content: http://www.ncbi.nlm.nih.gov/pubmed/6440533
Glucose metabolism in the extreme thermoacidophilic archaebacterium Sulfolobus solfataricus - PubMed Skip to main page content
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. 1984 Dec 1;224(2):407-14.
doi: 10.1042/bj2240407.

Glucose metabolism in the extreme thermoacidophilic archaebacterium Sulfolobus solfataricus

M De Rosa, A Gambacorta, B Nicolaus, P Giardina, E Poerio, V Buonocore

Glucose metabolism in the extreme thermoacidophilic archaebacterium Sulfolobus solfataricus

M De Rosa et al. Biochem J. .

Abstract

Sulfolobus solfataricus is a thermophilic archaebacterium able to grow at 87 degrees C and pH 3.5 on glucose as sole carbon source. The organism metabolizes glucose by two main routes. The first route involves an ATP-dependent phosphorylation to give glucose 6-phosphate, which readily isomerizes to fructose 6-phosphate. In the second route, glucose is converted into gluconate by an NAD+-dependent dehydrogenation; gluconate is then dehydrated to 2-keto-3-deoxygluconate, which, in turn, is cleaved to pyruvate and glyceraldehyde. Each metabolic step has been tested in vitro at 70 degrees C on dialysed homogenates or partially purified fractions; minimal requirements of single enzymes have been evaluated. Identification of the intermediates is based on chromatographic, spectroscopic and/or synthetic evidence and on specific enzymic assays. The oxidative breakdown of glucose to pyruvate occurring in S. solfataricus differs from the Entner-Doudoroff pattern in that there is an absence of any phosphorylation step.

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