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Link to original content: http://www.ncbi.nlm.nih.gov/pubmed/32092527
The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation - PubMed Skip to main page content
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Review
. 2020 Apr:61:58-64.
doi: 10.1016/j.conb.2020.01.010. Epub 2020 Feb 21.

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation

Georg Meisl  1 , Tuomas Pj Knowles  2 , David Klenerman  3
Affiliations
Review

The molecular processes underpinning prion-like spreading and seed amplification in protein aggregation

Georg Meisl et al. Curr Opin Neurobiol. 2020 Apr.

Abstract

The formation of aggregates from a range of normally soluble peptides and proteins is the hallmark of several neurodegenerative disorders, including Parkinson's and Alzheimer's diseases. Certain such aggregates possess the ability to replicate and spread pathology, within tissues and in some case also between organisms. An understanding of which processes govern the overall rate of aggregate formation is thus of key interest. Here, we discuss the fundamental molecular processes of protein aggregation, review how their rates can be determined by kinetic measurements in the test-tube, and explore the mechanistic similarities and differences to animal models and human disease. We conclude that a quantitative mathematical model for aggregate replication and spreading in vivo requires additional information but would provide a theoretical framework to understand results from different experiments and how they connect to human disease.

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