Non-coding RNA regulatory networks

doi:10.1016/j.bbagrm.2019.194417

Review

. 2020 Jun;1863(6):194417.

doi: 10.1016/j.bbagrm.2019.194417. Epub 2019 Sep 4.

Non-coding RNA regulatory networks

Simona Panni¹, Ruth C Lovering², Pablo Porras³, Sandra Orchard⁴

Affiliations

¹ Università della Calabria, Dipartimento di Biologia, Ecologia e Scienze della Terra, Via Pietro Bucci Cubo 6/C, Rende, CS, Italy. Electronic address: simona.panni@unical.it.
² Institute of Cardiovascular Science, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK. Electronic address: r.lovering@ucl.ac.uk.
³ European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton CB10 1SD, UK. Electronic address: pporras@ebi.ac.uk.
⁴ European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton CB10 1SD, UK. Electronic address: orchard@ebi.ac.uk.

PMID: 31493559
DOI: 10.1016/j.bbagrm.2019.194417

Review

Non-coding RNA regulatory networks

Simona Panni et al. Biochim Biophys Acta Gene Regul Mech. 2020 Jun.

. 2020 Jun;1863(6):194417.

doi: 10.1016/j.bbagrm.2019.194417. Epub 2019 Sep 4.

Authors

Simona Panni¹, Ruth C Lovering², Pablo Porras³, Sandra Orchard⁴

Affiliations

¹ Università della Calabria, Dipartimento di Biologia, Ecologia e Scienze della Terra, Via Pietro Bucci Cubo 6/C, Rende, CS, Italy. Electronic address: simona.panni@unical.it.
² Institute of Cardiovascular Science, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK. Electronic address: r.lovering@ucl.ac.uk.
³ European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton CB10 1SD, UK. Electronic address: pporras@ebi.ac.uk.
⁴ European Bioinformatics Institute (EMBL-EBI), European Molecular Biology Laboratory, Wellcome Genome Campus, Hinxton CB10 1SD, UK. Electronic address: orchard@ebi.ac.uk.

PMID: 31493559
DOI: 10.1016/j.bbagrm.2019.194417

Abstract

It is well established that the vast majority of human RNA transcripts do not encode for proteins and that non-coding RNAs regulate cell physiology and shape cellular functions. A subset of them is involved in gene regulation at different levels, from epigenetic gene silencing to post-transcriptional regulation of mRNA stability. Notably, the aberrant expression of many non-coding RNAs has been associated with aggressive pathologies. Rapid advances in network biology indicates that the robustness of cellular processes is the result of specific properties of biological networks such as scale-free degree distribution and hierarchical modularity, suggesting that regulatory network analyses could provide new insights on gene regulation and dysfunction mechanisms. In this study we present an overview of public repositories where non-coding RNA-regulatory interactions are collected and annotated, we discuss unresolved questions for data integration and we recall existing resources to build and analyse networks.

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Non-coding RNA regulatory networks

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Non-coding RNA regulatory networks

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