iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: http://www.ncbi.nlm.nih.gov/pubmed/28315200
Radiation-Induced Cardiovascular Disease - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 May;19(5):22.
doi: 10.1007/s11883-017-0658-x.

Radiation-Induced Cardiovascular Disease

Deepa Raghunathan  1 , Misha Iftikhar Khilji  2 , Saamir A Hassan  1 , Syed Wamique Yusuf  3
Affiliations
Review

Radiation-Induced Cardiovascular Disease

Deepa Raghunathan et al. Curr Atheroscler Rep. 2017 May.

Abstract

Purpose of review: Thoracic radiation therapy is an effective treatment for several malignancies, such as Hodgkin's lymphoma and breast cancer. Over the years, however, the incidence of cardiovascular events has increased in these patients, notably in younger survivors who do not have traditional risk factors. This review summarizes the pathology, incidence, clinical presentation, and management of cardiac events after radiation therapy.

Recent findings: Mediastinal radiation therapy accelerates the atherosclerosis process, resulting in early onset coronary artery disease. Valvular disease due to radiation therapy typically affects the left-sided valves, with aortic regurgitation being the most common. Rarely, it may lead to aortic stenosis requiring surgical interventions. Pericardial involvement includes acute and chronic pericardial disease and pericardial effusion. New studies are investigating the prevalence and pathogenesis of autonomic dysfunction in cancer survivors who have undergone mediastinal and neck radiation. Radiation therapy itself causes vascular endothelial dysfunction, resulting in clinical cardiovascular events, manifesting many years after completion of therapy. There remains little guidance regarding screening and therapies to prevent cardiovascular events in this population.

Keywords: Cardiovascular disease; Radiation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Strahlenther Onkol. 2016 Jun;192(6):359-67 - PubMed
    1. Int J Radiat Oncol Biol Phys. 2016 Mar 15;94(4):700-8 - PubMed
    1. Med Oncol. 2012 Dec;29(5):3581-6 - PubMed
    1. Cardiovasc Surg. 1996 Apr;4(2):222-6 - PubMed
    1. PLoS One. 2015 Jun 05;10(6):e0128539 - PubMed

MeSH terms

LinkOut - more resources