iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: http://www.ncbi.nlm.nih.gov/pubmed/26354531
Efficacy of fish intake on vitamin D status: a meta-analysis of randomized controlled trials - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2015 Oct;102(4):837-47.
doi: 10.3945/ajcn.114.105395. Epub 2015 Sep 9.

Efficacy of fish intake on vitamin D status: a meta-analysis of randomized controlled trials

Ulrike Lehmann  1 , Hanne Rosendahl Gjessing  2 , Frank Hirche  3 , Andreas Mueller-Belecke  4 , Oddrun Anita Gudbrandsen  5 , Per Magne Ueland  6 , Gunnar Mellgren  2 , Lotte Lauritzen  7 , Helen Lindqvist  8 , Anita Lill Hansen  9 , Arja T Erkkilä  10 , Gerda K Pot  11 , Gabriele I Stangl  3 , Jutta Dierkes  12
Affiliations
Free article
Meta-Analysis

Efficacy of fish intake on vitamin D status: a meta-analysis of randomized controlled trials

Ulrike Lehmann et al. Am J Clin Nutr. 2015 Oct.
Free article

Abstract

Background: It is well known that fish is the major natural source of vitamin D in the diet; therefore, this meta-analysis investigated the influence of fish consumption in randomized controlled trials (RCTs) on serum 25-hydroxyvitamin D [25(OH)D] concentrations.

Objective: A literature search was carried out in Medline, Embase, Web of Science, and the Cochrane Library (up to February 2014) for RCTs that investigated the effect of fish consumption on 25(OH)D concentrations in comparison to other dietary interventions.

Results: Seven articles and 2 unpublished study data sets with 640 subjects and 14 study groups met the inclusion criteria and were included in this meta-analysis. Compared with controls, the consumption of fish increased 25(OH)D concentrations, on average, by 4.4 nmol/L (95% CI: 1.7, 7.1 nmol/L; P < 0.0001, I(2) = 25%; 9 studies).The type of the fish also played a key role: the consumption of fatty fish resulted in a mean difference of 6.8 nmol/L (95% CI: 3.7, 9.9 nmol/L; P < 0.0001, I(2) = 0%; 7 study groups), whereas for lean fish the mean difference was 1.9 nmol/L (95% CI: -2.3, 6.0 nmol/L; P < 0.38, I(2) = 37%; 7 study groups). Short-term studies (4-8 wk) showed a mean difference of 3.8 nmol/L (95% CI: 0.6, 6.9 nmol/L; P < 0.02, I(2) = 38%; 10 study groups), whereas in long-term studies (∼6 mo) the mean difference was 8.3 nmol/L (95% CI: 2.1, 14.5 nmol/L; P < 0.009, I(2) = 0%; 4 study groups).

Conclusion: As the major food source of vitamin D, fish consumption increases concentrations of 25(OH)D, although recommended fish intakes cannot optimize vitamin D status.

Keywords: 25(OH)D; fish intake; intervention studies; meta-analysis; randomized controlled trial; vitamin D; vitamin D status.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types