iBet uBet web content aggregator. Adding the entire web to your favor.
iBet uBet web content aggregator. Adding the entire web to your favor.



Link to original content: http://www.ncbi.nlm.nih.gov/pubmed/25239654
Tau PET imaging in Alzheimer's disease - PubMed Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Nov;14(11):500.
doi: 10.1007/s11910-014-0500-6.

Tau PET imaging in Alzheimer's disease

Nobuyuki Okamura  1 , Ryuichi Harada, Shozo Furumoto, Hiroyuki Arai, Kazuhiko Yanai, Yukitsuka Kudo
Affiliations
Review

Tau PET imaging in Alzheimer's disease

Nobuyuki Okamura et al. Curr Neurol Neurosci Rep. 2014 Nov.

Abstract

In several neurodegenerative diseases that are collectively called tauopathies, progressive accumulation of tau in the brain is closely associated with neurodegeneration and cognitive impairment. Noninvasive detection of tau protein deposits in the brain would be useful to diagnose tauopathies as well as to track and predict disease progression. Recently, several tau PET tracers including T807, THK-5117, and PBB3 have been developed and succeeded in imaging neurofibrillary pathology in vivo. For use of tau PET as a biomarker of tau pathology in Alzheimer's disease, PET tracers should have high affinity to PHF-tau and high selectivity for tau over amyloid-β and other protein deposits. PET tau imaging enables the longitudinal assessment of the spatial pattern of tau deposition and its relation to amyloid-β pathology and neurodegeneration. This technology could also be applied to the pharmacological assessment of anti-tau therapy, thereby allowing preventive interventions.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Neurosci. 2001 Dec 15;21(24):RC189 - PubMed
    1. Am J Geriatr Psychiatry. 2002 Jan-Feb;10(1):24-35 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Jul;83(13):4913-7 - PubMed
    1. J Alzheimers Dis. 2014;38(1):171-84 - PubMed
    1. Behav Neurol. 2009;21(1):117-28 - PubMed

Publication types

MeSH terms

LinkOut - more resources