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Link to original content: http://www.ncbi.nlm.nih.gov/pubmed/23803871
Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression - PubMed Skip to main page content
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Randomized Controlled Trial
. 2013;34(4):287-93.

Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression

Peter Sos  1 , Monika Klirova, Tomas Novak, Barbora Kohutova, Jiri Horacek, Tomas Palenicek
Affiliations
  • PMID: 23803871
Randomized Controlled Trial

Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression

Peter Sos et al. Neuro Endocrinol Lett. 2013.

Abstract

Objectives: Ketamine and other NMDA (N-methyl-D-aspartate) antagonists produce fast-acting antidepressant-like effects, although the underlying mechanism is unclear. Furthermore, high affinity NMDA antagonists such as ketamine are associated with psychotomimetic effects. To date the link between the antidepressant and psychotomimetic effects of ketamine has not been explored. We examined the relationship between the antidepressant and psychotomimetic effects of a single ketamine infusion in subjects diagnosed with major depressive disorder.

Methods: In a double-blind, cross-over, placebo-controlled, two weeks clinical trial we studied the effects of ketamine (0.54 mg/kg within 30 min) in a group of 27 hospitalized depressive patients.

Results: Higher intensity of psychotomimetic symptoms, measured using BPRS, during ketamine administration correlated with alleviation in mood ratings during the following week with maximum on day seven. Ketamine was superior to placebo in all visits (day 1, 4, and 7) assessed by MADRS with effect size (Cohen´s d) of 0.62, 0.57, and 0.44 respectively. There was no significant correlation between ketamine and nor-ketamine plasma levels and MADRS score change at any study time point.

Conclusion: The substantial relationship between ketamine's antidepressant and psychotomimetic effects was found. This relationship could be mediated by the initial steps of ketamine's action, trough NMDA receptors, shared by both ketamine's clinical effects.

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