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Link to original content: http://www.ncbi.nlm.nih.gov/pubmed/22044921
Brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing the NF-κB pathway in human dermal fibroblasts - PubMed Skip to main page content
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. 2012 Jan 15;674(2-3):80-6.
doi: 10.1016/j.ejphar.2011.10.016. Epub 2011 Oct 25.

Brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing the NF-κB pathway in human dermal fibroblasts

Young-Rae Lee  1 , Eun-Mi Noh, Ji-Hye Han, Jeong-Mi Kim, Jin-Ki Hwang, Bo-Mi Hwang, Eun-Yong Chung, Byeong-Soo Kim, Sung-Ho Lee, Seung Jin Lee, Jong-Suk Kim
Affiliations

Brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing the NF-κB pathway in human dermal fibroblasts

Young-Rae Lee et al. Eur J Pharmacol. .

Abstract

Brazilin (7, 11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10 (6H)-tetrol), the major component of Caesalpinia sappan L., is a natural red pigment used for histological staining. Recent studies have shown that brazilin exhibits distinct biological effects, including anti-hepatotoxicity, antiplatelet activity, and anti-inflammatory activities. In the present study, we evaluated the effects of brazilin on MMP-1 and -3 expressions in human dermal fibroblasts exposed to ultraviolet B (UVB) irradiation. Brazilin showed protective effect on UVB-induced loss of cell viability of fibroblasts. Brazilin also blocked significantly UVB-induced Reactive Oxygen Species generation in fibroblasts. Brazilin inhibited UVB-induced MMP-1/3 expressions and secretions in a dose-dependent manner. Moreover, UVB-induced NF-κB activation was completely blocked by treatment with brazilin. These findings suggest that brazilin inhibits UVB-induced MMP-1/3 expressions and secretions by suppressing of NF-κB activation in human dermal fibroblasts. Thus, brazilin might be used as a potential agent for treatment of UV-induced skin photoaging.

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