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Link to original content: http://www.ncbi.nlm.nih.gov/pubmed/21609959
Update of PROFEAT: a web server for computing structural and physicochemical features of proteins and peptides from amino acid sequence - PubMed Skip to main page content
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. 2011 Jul;39(Web Server issue):W385-90.
doi: 10.1093/nar/gkr284. Epub 2011 May 23.

Update of PROFEAT: a web server for computing structural and physicochemical features of proteins and peptides from amino acid sequence

H B Rao  1 , F Zhu, G B Yang, Z R Li, Y Z Chen
Affiliations

Update of PROFEAT: a web server for computing structural and physicochemical features of proteins and peptides from amino acid sequence

H B Rao et al. Nucleic Acids Res. 2011 Jul.

Abstract

Sequence-derived structural and physicochemical features have been extensively used for analyzing and predicting structural, functional, expression and interaction profiles of proteins and peptides. PROFEAT has been developed as a web server for computing commonly used features of proteins and peptides from amino acid sequence. To facilitate more extensive studies of protein and peptides, numerous improvements and updates have been made to PROFEAT. We added new functions for computing descriptors of protein-protein and protein-small molecule interactions, segment descriptors for local properties of protein sequences, topological descriptors for peptide sequences and small molecule structures. We also added new feature groups for proteins and peptides (pseudo-amino acid composition, amphiphilic pseudo-amino acid composition, total amino acid properties and atomic-level topological descriptors) as well as for small molecules (atomic-level topological descriptors). Overall, PROFEAT computes 11 feature groups of descriptors for proteins and peptides, and a feature group of more than 400 descriptors for small molecules plus the derived features for protein-protein and protein-small molecule interactions. Our computational algorithms have been extensively tested and used in a number of published works for predicting proteins of specific structural or functional classes, protein-protein interactions, peptides of specific functions and quantitative structure activity relationships of small molecules. PROFEAT is accessible free of charge at http://bidd.cz3.nus.edu.sg/cgi-bin/prof/protein/profnew.cgi.

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Figures

Figure 1.
Figure 1.
PROFEAT new web page.
See this image and copyright information in PMC

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