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Link to original content: http://www.ncbi.nlm.nih.gov/pubmed/17709402
Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation - PubMed Skip to main page content
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Review
. 2007 Dec;82(6):1375-81.
doi: 10.1189/jlb.0607338. Epub 2007 Aug 20.

Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

Philippe Van Lint  1 , Claude Libert
Affiliations
Review

Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

Philippe Van Lint et al. J Leukoc Biol. 2007 Dec.

Abstract

The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to degradation of the extracellular matrix; however, in recent years, it has become evident that these proteases can modify many nonmatrix substrates, such as cytokines and chemokines. The use of MMP-deficient animals has revealed that these proteases can indeed influence the progression of various inflammatory processes. This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration.

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