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Link to original content: http://www.ncbi.nlm.nih.gov/pubmed/16451222
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Review
. 2006 Jan;18(1):65-76.
doi: 10.1111/j.1365-2826.2005.01379.x.

Cell biology of the ghrelin receptor

J P Camiña  1
Affiliations
Review

Cell biology of the ghrelin receptor

J P Camiña. J Neuroendocrinol. 2006 Jan.

Abstract

Ghrelin, a gastric peptide involved in growth hormone release and energy homeostasis, is the endogenous ligand of the growth hormone secretagogue receptor type 1a (GHS-R1a), a G-protein coupled receptor mainly expressed in the pituitary and hypothalamus. This receptor mediates the main ghrelin-stimulated endocrine actions and some of the nonendocrine actions. However, a number of nonendocrine actions associated with ghrelin appear to be mediated by various GHS-R1a-related receptor subtypes, which are widely distributed in the central and peripheral tissues. This review summarises data concerning the localisation, regulation and function of GHS-R1a, as well as related receptors.

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