Review
doi: 10.1038/nrn1700.
Role of the immune system in chronic pain
Affiliations
- PMID: 15995723
- DOI: 10.1038/nrn1700
Item in Clipboard
Review
Role of the immune system in chronic pain
Nat Rev Neurosci.
2005 Jul.
Abstract
During the past two decades, an important focus of pain research has been the study of chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity - spontaneous pain and hyperalgesia - that is associated with these states. For some time it has been recognized that inflammatory mediators released from immune cells can contribute to these persistent pain states. However, it has only recently become clear that immune cell products might have a crucial role not just in inflammatory pain, but also in neuropathic pain caused by damage to peripheral nerves or to the CNS.
Similar articles
-
Immune and inflammatory mechanisms in neuropathic pain.Brain Res Rev. 2006 Aug;51(2):240-64. doi: 10.1016/j.brainresrev.2005.11.004. Epub 2006 Jan 4. Brain Res Rev. 2006. PMID: 16388853 Review.
-
A twist in anti-inflammation: annexin 1 acts via the lipoxin A4 receptor.Prostaglandins Leukot Essent Fatty Acids. 2005 Sep-Oct;73(3-4):211-9. doi: 10.1016/j.plefa.2005.05.008. Prostaglandins Leukot Essent Fatty Acids. 2005. PMID: 15982865 Review.
-
Immune and glial cell factors as pain mediators and modulators.Exp Neurol. 2005 Apr;192(2):444-62. doi: 10.1016/j.expneurol.2004.11.001. Exp Neurol. 2005. PMID: 15755561 Review.
-
Pathophysiology of peripheral neuropathic pain: immune cells and molecules.Anesth Analg. 2007 Sep;105(3):838-47. doi: 10.1213/01.ane.0000275190.42912.37. Anesth Analg. 2007. PMID: 17717248 Review.
-
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation.Nat Rev Immunol. 2009 Jan;9(1):62-70. doi: 10.1038/nri2470. Nat Rev Immunol. 2009. PMID: 19104500 Review.
Cited by
-
Immune drivers of pain resolution and protection.Nat Immunol. 2024 Dec;25(12):2200-2208. doi: 10.1038/s41590-024-02002-9. Epub 2024 Nov 11. Nat Immunol. 2024. PMID: 39528810 Review.
-
The influence of sex on neuroimmune communication, pain, and physiology.Biol Sex Differ. 2024 Oct 22;15(1):82. doi: 10.1186/s13293-024-00660-w. Biol Sex Differ. 2024. PMID: 39439003 Free PMC article. Review.
-
A microfluidic model of the first sensory synapse for analgesic target discovery.Mol Pain. 2024 Jan-Dec;20:17448069241293286. doi: 10.1177/17448069241293286. Mol Pain. 2024. PMID: 39415077 Free PMC article.
-
Risk of infections among persons treated with opioids for chronic pain: a systematic review and meta-analysis protocol.BMJ Open. 2024 Oct 15;14(10):e083791. doi: 10.1136/bmjopen-2023-083791. BMJ Open. 2024. PMID: 39414287 Free PMC article.
-
An interdisciplinary perspective on peripheral drivers of pain in rheumatoid arthritis.Nat Rev Rheumatol. 2024 Nov;20(11):671-682. doi: 10.1038/s41584-024-01155-z. Epub 2024 Sep 6. Nat Rev Rheumatol. 2024. PMID: 39242949 Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
