Capsaicin pepper, cancer and ethnicity
- PMID: 12208187
- DOI: 10.1016/s0306-9877(02)00152-4
Capsaicin pepper, cancer and ethnicity
Abstract
The 'hot' sensation produced by exposure to pepper is apparently due to two natural carcinogens: capsaicin in chili type peppers and safrole in black/white pepper. There are four cookeries in the United States that are noted for their high pepper content: Mexican-American, Cajun, white Creole, and black Creole. Each is largely confined to a single ethnic-cultural group which is concentrated in some counties. By use of county population and mortality data, significantly higher rates for stomach and liver cancer were found in counties inhabited by these four ethnic-cultural groups than in matched control counties. This involved both sexes. The cancer increase was dependent on the concentration of these groups in a county. These results strengthen and extend an earlier case-control study which found odds ratios above 5 for the stomach cancer association with capsaicin pepper. It is further evidence that capsaicin is a human carcinogen.
Similar articles
-
Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin.Int J Toxicol. 2007;26 Suppl 1:3-106. doi: 10.1080/10915810601163939. Int J Toxicol. 2007. PMID: 17365137 Review.
-
A comprehensive review of the carcinogenic and anticarcinogenic potential of capsaicin.Toxicol Pathol. 2012 Aug;40(6):847-73. doi: 10.1177/0192623312444471. Epub 2012 May 4. Toxicol Pathol. 2012. PMID: 22563012 Review.
-
Chili pepper consumption and gastric cancer in Mexico: a case-control study.Am J Epidemiol. 1994 Feb 1;139(3):263-71. doi: 10.1093/oxfordjournals.aje.a116993. Am J Epidemiol. 1994. PMID: 8116601
-
Tumorigenicity and mutagenicity studies with capsaicin of hot peppers.Anticancer Res. 1984 May-Jun;4(3):117-9. Anticancer Res. 1984. PMID: 6380397
-
Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen?Food Chem Toxicol. 1996 Mar;34(3):313-6. doi: 10.1016/0278-6915(95)00108-5. Food Chem Toxicol. 1996. PMID: 8621114 Review.
Cited by
-
Capsaicinoids and Their Effects on Cancer: The "Double-Edged Sword" Postulate from the Molecular Scale.Cells. 2023 Nov 4;12(21):2573. doi: 10.3390/cells12212573. Cells. 2023. PMID: 37947651 Free PMC article. Review.
-
Protective Role of Capsaicin in Neurological Disorders: An Overview.Neurochem Res. 2022 Jun;47(6):1513-1531. doi: 10.1007/s11064-022-03549-5. Epub 2022 Feb 12. Neurochem Res. 2022. PMID: 35150419 Review.
-
Pro-inflammatory and toxicological evaluation of Hepacare® in mice.J Taibah Univ Med Sci. 2017 Mar 31;12(4):313-323. doi: 10.1016/j.jtumed.2017.02.004. eCollection 2017 Aug. J Taibah Univ Med Sci. 2017. PMID: 31435257 Free PMC article.
-
Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes.Chem Res Toxicol. 2013 Jan 18;26(1):55-66. doi: 10.1021/tx300366k. Epub 2012 Nov 6. Chem Res Toxicol. 2013. PMID: 23088752 Free PMC article.
-
Capsaicin affects brain function in a model of hepatic encephalopathy associated with fulminant hepatic failure in mice.Br J Pharmacol. 2009 Oct;158(3):896-906. doi: 10.1111/j.1476-5381.2009.00368.x. Epub 2009 Sep 18. Br J Pharmacol. 2009. PMID: 19764982 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
